This Friday I'm going to be dropping E with my friend and his girlfriend (first time for both of them), and it occurred to me that I really need to plan out the dosage ahead of time for this one. My last dose (~1 1/2 weeks ago) was 1 pill to start and then one an hour later as I was barely feeling anything. Underwhelming experience however I came out of it with no hangover, so my Serotonin was not depleted from the last time I used it.
Time before that was 4 days prior, where I had used 7 (!) pills over the course of the night. Even worse, I had done 2 pills the day before, but none for a year before that. My serotonin levels are definately going to be up to par, I wasn't depleted from the last time I did E and I did Mephedrone last night and it worked beautifully. I've taken 5-HTP after taking anything that affected Serotonin to make sure that it won't be an issue.
Now for the problem, I don't know how much to take for one simple reason - I'm on 450mg of Wellbutrin daily. Now this makes things complicated because the relevant side effects go in both directions for adjusting dosage.
1. I am SEVERELY CYP2D6 deficient. It's a side effect of one of the metabolites (meaning it's not even remotely viable for me to stop taking the drug before a roll, I'd still have dick all for CYP2D6). To give you an idea of how bad this is, taking two cold pills with DXM in them will give me 2nd plateau affects. This was back when I was only taking 300mg a day too, it would only have gotten worse since I upped the dosage.
Now from what I've read this is supposed to severely impair the metabolism of MDMA, subsequently meaning I should lower my dose.
Except at the same time there is a secondary effect:
2. Wellbutrin is a very mild SRI, but enough of one to need a bit extra to get over the hump. Realistically this may also be compensating for the NDRI aspect of the drug as well but regardless, while having a full on proper roll is possible it does theoretically require taking more.
And to make things even MORE confusing, this is my usage pattern for the last year:
Thanksgiving '09 - Day 1 rolled with 1+1, Day 2 dropped all 4 at once
That... was a fucking horrible comedown/hangover, I cried like a baby. And then I regained the capability of being happy and we moved onwards...
~October '10 - Drop 2 pills with my sister and mutual friend, fall asleep feeling very underwhelmed with the experience.
Next day - Bought 200 pills that day, and figured testing it out was in order (this never ends well for me, I need to stop testing my drugs!) so me and a few friends had some fun. Ended up taking 7 by the time the night was over, probably overkill but I definately hit the point where you're basically drowning in Euphoria... only part of E I've ever found remotely addictive.
Next day was horrible (as expected for rolling twice in a row), day after that was still bad so Iran to buy some 5-HTP/Vit C/Magnesium supplements to try to give myself a boost. This helped noticeably and 2 days later I was good as new. This was when I dropped 1+1 for some reason or another (it was actually intended to be an act of self destruction, but I came out of it more optimistic than I had been in months... funny how life works sometimes). But at that dose it was again very underwhelming, I only intended to take one but I didn't feel it after an hour so I took the second. It was a good experience but not euphoric in the slightest, I didn't hit a high enough threshold for that. Wake up the next day with an afterglow and it was all good from there.
So that's the background, now I need to figure out how much I need to take to get the intended effects considering:
Medium roll (not low dose, but not writhing in euphoria either)
Very low CYP2D6
No serotonin depletion
Mild SRI effect
Possible small amount of tolerance (could have quite possibly faded by now)
I still have a buttload of pills despite selling a bunch to friends so that isn't an issue, but I'm not sure where the line from threshold dose->good roll->amazingly euphoric->soft cap, only side effects increase from this point.
Any takers?
Time before that was 4 days prior, where I had used 7 (!) pills over the course of the night. Even worse, I had done 2 pills the day before, but none for a year before that. My serotonin levels are definately going to be up to par, I wasn't depleted from the last time I did E and I did Mephedrone last night and it worked beautifully. I've taken 5-HTP after taking anything that affected Serotonin to make sure that it won't be an issue.
Now for the problem, I don't know how much to take for one simple reason - I'm on 450mg of Wellbutrin daily. Now this makes things complicated because the relevant side effects go in both directions for adjusting dosage.
1. I am SEVERELY CYP2D6 deficient. It's a side effect of one of the metabolites (meaning it's not even remotely viable for me to stop taking the drug before a roll, I'd still have dick all for CYP2D6). To give you an idea of how bad this is, taking two cold pills with DXM in them will give me 2nd plateau affects. This was back when I was only taking 300mg a day too, it would only have gotten worse since I upped the dosage.
Now from what I've read this is supposed to severely impair the metabolism of MDMA, subsequently meaning I should lower my dose.
Except at the same time there is a secondary effect:
2. Wellbutrin is a very mild SRI, but enough of one to need a bit extra to get over the hump. Realistically this may also be compensating for the NDRI aspect of the drug as well but regardless, while having a full on proper roll is possible it does theoretically require taking more.
And to make things even MORE confusing, this is my usage pattern for the last year:
Thanksgiving '09 - Day 1 rolled with 1+1, Day 2 dropped all 4 at once
That... was a fucking horrible comedown/hangover, I cried like a baby. And then I regained the capability of being happy and we moved onwards...
~October '10 - Drop 2 pills with my sister and mutual friend, fall asleep feeling very underwhelmed with the experience.
Next day - Bought 200 pills that day, and figured testing it out was in order (this never ends well for me, I need to stop testing my drugs!) so me and a few friends had some fun. Ended up taking 7 by the time the night was over, probably overkill but I definately hit the point where you're basically drowning in Euphoria... only part of E I've ever found remotely addictive.
Next day was horrible (as expected for rolling twice in a row), day after that was still bad so Iran to buy some 5-HTP/Vit C/Magnesium supplements to try to give myself a boost. This helped noticeably and 2 days later I was good as new. This was when I dropped 1+1 for some reason or another (it was actually intended to be an act of self destruction, but I came out of it more optimistic than I had been in months... funny how life works sometimes). But at that dose it was again very underwhelming, I only intended to take one but I didn't feel it after an hour so I took the second. It was a good experience but not euphoric in the slightest, I didn't hit a high enough threshold for that. Wake up the next day with an afterglow and it was all good from there.
So that's the background, now I need to figure out how much I need to take to get the intended effects considering:
Medium roll (not low dose, but not writhing in euphoria either)
Very low CYP2D6
No serotonin depletion
Mild SRI effect
Possible small amount of tolerance (could have quite possibly faded by now)
I still have a buttload of pills despite selling a bunch to friends so that isn't an issue, but I'm not sure where the line from threshold dose->good roll->amazingly euphoric->soft cap, only side effects increase from this point.
Any takers?
