Prolintane analogue with ethyleneimine modification?

[danceofdays]

What would be the possible implications of replacing the pyrrolidine ring in prolintane with an aziridine (ethyleneimine) ring? Also, if the alpha-propyl group was changed to an alpha-methyl, would the potency and comparison to amphetamine increase?

 

[sekio]

Aziridine is horribly unstable as a functional group.

 

[wungchow]

Would probably alkylate something in your body.

 

[indelibleface]

I'm not content with any triangle shaped molecules anywhere near my body.

 

[nuke]

The triforce moiety is especially good at MAO-I inhibition.

 

[danceofdays]

The triforce moiety is especially good at MAO-I inhibition.

hahaha

 

[danceofdays]

Also, what do you guys think of these two compounds?

The first only appears on isomerdesign, the second is for sale by some pretty sketchy vendors but looks interesting for sure.

EDIT: the second picture is wrong, the molecule I've found for sale is para-methylated.

 

[sekio]

I can only imagine adding a cyclopropyl on the alpha carbon of phenethylamines to reduce potency both as a stimulant and as a 5-HT ligand while possibly incurring MAOI activity (a la tranylcypromine)