Limpet_Chicken
Bluelighter
So, I'd like to know if there is potential for continuing damage years AFTER an initial, severe excitotoxic insult (it nearly killed me, twice)
The setting was acute, severe and extremely protracted barbiturate withdrawal. At first, cared for in intensive care after ODing when plasma levels of a very long-lingering but nevertheless not at all phenobarb-esque subjectively, and damned abusable barb mounted up and got me. I'd built up a dependence on the stuff and whilst I didn't like the fact, I KNEW I had more than enough to taper. Only problem was the OD, someone snitched on me and I got jailed. Did a cold turkey 'detox' and damn near died again, after months of protracted severe DTs, during which I didn't eat, didn't know food was there, and I doubt I could have got it down me anyway if I did. No way in hell with THAT fight or flight response.
Barbs both have the well known GABAergic agonist effects, and additionally they bind in an antagonistic mode to AMPA type ionotropic glutamate receptors. And perhaps of interest, They have a weird long-lasting (even on electrophysiological patch-clamp conditions it takes PROLONGED washout to reduce say, pentobarbital maximal inhibition to say, 70-75% of its masximal, as the ligand binds in such a manner as not to easily un-bind)
Now, I used to be, well, a lot more brilliant than I am. It feels as though its THERE, I just can't access it, like a scratched hard drive with the read head skipping over when searching for data. Memory severely impaired, difficult to find words in speech, I often have to circumlocute mentally to find the correct term, I can't remember what, but I had to go from the etymology of a word embodied by the concept that I wished to convey, in ancient greek, and derive it thus, from the english of the equivalent latin term.
And substituting similar sounding phonetically but mispelled words in typing, and having to correct from rote. Along with ataxia, seizures, Recently I started, to slowly lose the ability to feel hunger and thirst. Its a struggle to eat and drink at all now, theres no drive to. And I rarely take psychostimulants, although I am actually considering it to get along. Memantine, although I have been struggling to try persuade my doc to give me a script more or less restores me from a ghost of my former self to being fully alive again. Other NMDA antagonists do to a degree but not with the same utility as memantine. If I can get it or find a source for it elsewhere, think combining it with an AMPAkine to offset the awful memory loss might be worth a shot?
Its getting to the point of dangerous, the memory loss. Forgot the cap was off a bottle of SOCl2 recently, for example until the stench began to penetrate the filter of my mask, and my eyes were stinging like they were drying off after a bath in chloroacetone.
The setting was acute, severe and extremely protracted barbiturate withdrawal. At first, cared for in intensive care after ODing when plasma levels of a very long-lingering but nevertheless not at all phenobarb-esque subjectively, and damned abusable barb mounted up and got me. I'd built up a dependence on the stuff and whilst I didn't like the fact, I KNEW I had more than enough to taper. Only problem was the OD, someone snitched on me and I got jailed. Did a cold turkey 'detox' and damn near died again, after months of protracted severe DTs, during which I didn't eat, didn't know food was there, and I doubt I could have got it down me anyway if I did. No way in hell with THAT fight or flight response.
Barbs both have the well known GABAergic agonist effects, and additionally they bind in an antagonistic mode to AMPA type ionotropic glutamate receptors. And perhaps of interest, They have a weird long-lasting (even on electrophysiological patch-clamp conditions it takes PROLONGED washout to reduce say, pentobarbital maximal inhibition to say, 70-75% of its masximal, as the ligand binds in such a manner as not to easily un-bind)
Now, I used to be, well, a lot more brilliant than I am. It feels as though its THERE, I just can't access it, like a scratched hard drive with the read head skipping over when searching for data. Memory severely impaired, difficult to find words in speech, I often have to circumlocute mentally to find the correct term, I can't remember what, but I had to go from the etymology of a word embodied by the concept that I wished to convey, in ancient greek, and derive it thus, from the english of the equivalent latin term.
And substituting similar sounding phonetically but mispelled words in typing, and having to correct from rote. Along with ataxia, seizures, Recently I started, to slowly lose the ability to feel hunger and thirst. Its a struggle to eat and drink at all now, theres no drive to. And I rarely take psychostimulants, although I am actually considering it to get along. Memantine, although I have been struggling to try persuade my doc to give me a script more or less restores me from a ghost of my former self to being fully alive again. Other NMDA antagonists do to a degree but not with the same utility as memantine. If I can get it or find a source for it elsewhere, think combining it with an AMPAkine to offset the awful memory loss might be worth a shot?
Its getting to the point of dangerous, the memory loss. Forgot the cap was off a bottle of SOCl2 recently, for example until the stench began to penetrate the filter of my mask, and my eyes were stinging like they were drying off after a bath in chloroacetone.
).
...hehe that lass has one hell of a hilarious turn of phrase and could snark the silver tongue off of the devil his own self (and WHAT a hottie too