A) It's extremely hard to source.
B) The long-term effects on human health aren't well researched.
C) There is a much better, more reliable solution to reducing and maintaining tolerance low, and that is ULDN. To make matters even better ULDN both shortens as well as lessens the intensity of withdrawals by like 80%. This is something that I accidentally discovered back in April when I ran out of heroin. I was mentally preparing for three days of absolute hell, but all I experienced was anxiety, freezing, sweating, insomnia, depression, goosebumps and all of these symptoms subsided after 24h, leaving me only with PAWS. I actually linked to a study written by the biochemist Jonathan Ott self-experimented with Naltrexone in microgram dosages to obviate withdrawals:
https://bluelight.org/xf/threads/ul...tolerance-to-opioids-low.914985/post-15823696
This substance is so incredibly versatile that it's a godsend for us dope fiends. Without it I would have to go through 3 days of full spectrum body-mind-splatter-gore-torture and then 7 days of residual symptoms until I feel somewhat well again. ULDN however seems to cram all this into 24h (might be shorter or longer depending on your metabolism) and also massively decreases the intensity. Just try it out yourselves guys. I'm suprised this isn't well known.
By the way, the pharmaceutical industry once had plans to create a CombiPrep consisting of Oxy and naltrexone in microdosages but when they found out that it effectively and reliably prevents tolerance from building up in patients they quickly discarded this project as it would massively cut into their profits.