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Problems caused by tyrosine after daily d-amphetamine use?

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AlexxRed

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Would there be any possible problems (or no point at all?) from using Tyrosine (daily) after dexamphetamine use?

I can only see that it could have benefits if taken a few hours before bedtime, after d-amphetamine has worn off.
 
I don't think you'd have any problems, I don't think you'd notice much at all, if anything.

what it should do, if I understand properly, is allow your body to create more of what you want in your brain to get a more euphoric effect out of the amphetamine. I dunno if this is ADD material, though. I'm often wrong, though.

Hammilton
 
^^^^
thanks for your reply. I'm not looking to get a more euphoric effect, just thought it would be beneficial to boost neurotransmitters depleted by using dex during the day.

There are a lot of people who swear by using these supplements for recovery after amphetamine use. But what I'm wondering is if this is a good idea, if done daily, for someone that uses dex?
 
the question is how this would affect your body`s natural tyrosine usage and uptake...dont know.
 
per my understanding, the body can't make tyrosine on it's own, and needs to use phenylalanine as a precurser, so that shouldn't be a problem. It might slow down phenylalanine conversion.

tyrosine then is converted to L-Dopa. I don't know if the conversion rate is limited, though, as in, 20Xg's made per hour, no more.

Best you can do is try it. I sincerely doubt there's any risk that your body is going to stop converting phenylalanine into tyrosine, but I suppose that's possible. We actually eat a lot of tyrosine anyway, I don't know if a supplement is needed
 
Tyrosine>l-dopa is a rate limited conversion (tyrosine hydroxylase). Don't remember what the limit is, but the info is out there. I remember reading that while there is enough room in the system for tyrosine supplementation to increase DA levels, this increase is smaller than what is possible for 5-htp>serotonin.
I don't think phenylalanine offers any real advantage for dopamine production, and just puts you a step behind tyrosine. Keep in mind that vitamin b6 and vitamin c are necessary cofactors in dopamine synthesis so supplementing those would be a good idea. Also, amino acids compete for uptake, so taking it before or after any other amino acid intake might be a good idea. And if it does work well, it could possibly interfere with sleeping (though I'm saying that completely theoretically).
And I can't really answer your question if there would be any problem with doing this. Maybe there would be some down regulation of one thing or another, but I really don't know. I wouldn't think it could be a real problem. If you haven't, try looking into side effects of tyrosine supplements (if that isn't obvious enough).
 
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If tyrosine caused an increase of dopamine over what is "normal", the body in an effort of homeostasis would maybe downregulate receptors or something. It's known that large enough amounts of amphetamine for long enough can do this (as you said), but I don't know if tyrosine could have any such effect. Personally, I have yet to try tyrosine (although I plan to), but I think it may be logical to say that this may occur if tyrosine raises dopamine levels higher than what is seen as natural by the body. Whether this is the case, I can't say. There might be some reason why this isn't the case, I really don't know. Perhaps someone else does.
 
If tyrosine caused an increase of dopamine over what is "normal", the body in an effort of homeostasis would maybe downregulate receptors or something
Click to expand...

Your first statement mentions that ring hydroxylation is rate limited. Homeostasis would therfore occur naturally regardless of whether dietary intake of tyrosine alters.

Tyrosine>l-dopa is a rate limited conversion (tyrosine hydroxylase)
Click to expand...
 
I think it would be a good idea, especially if coupled with some other anti-oxidants and perhaps some piracetam. I really don't think it would hurt and would probably NOT cause down-regulation of the hydroxylases.

IMHO
 
there is research to show that l-tyrosine will block cravings, i don't have it on me but look around.

phenylalanine will not be better, but acetyl-l-tyrosine would be

we had a team member here who did his thesis in hawaii during the ice epidemic using a combination of l-tryptophan and l-tyrosine in recovering meth addicts - google "saave" which was the brand name

also we produced a similar product in NZ called "STOP P" and there was no formal clinical trial a prominent mental health lecturer found that in groups for recovering addicts, that those on STOP P had less cravings, more stability and mental clarity (no jitters) than those who were not taking the supplement.

It also had a number of other co-factors to support neurotransmitter metabolism, and other sedating and relaxing phytonutrients to support return to homeostasis

hope that helps.
 
I wouldn't take l-tyrosine right before bedtime, as it might interfere with sleep if it has the effect you are looking for. However, you could probably get away with taking it a few hours before.
 
Thanks to all for your input. It is appreciated.

Ultimately what I am trying to answer is: would taking l-tyrosine daily in conjunction with my prescribed dexamphetamine be of any possible benefit. If so how might this be be done? If not then I'd love to hear of any other suggestions. (I already eat well, exercise and take anti oxidants)

I'm not looking for any 'magic' answer. I don't believe that drugs alone can not be a total solution. However, clearly there are many problems associated with long term amphetamine use. If there anything that can be used in conjunction with my medication to make it a more safe and viable option I'd like to hear about it.

Your thoughts please.
 
I know only one thing for sure. DO NOT take l-tyrosine then eat meat after a long weekend on the meth if you intend to sleep anytime soon...
 
I'd take it in the morning with a B complex to help metabolize them. Only because it increases the ehh 'stimulating' neurotransmitters so taking them before bed could pose a risk to your sleep. I'd recommend magnesium Taurate before bed.
 
I don't think it will be of any benefit health wise, you are adding dopamine and adrenaline to your dex-amphetamine intake. It will make it more stimulating.....it could allow you to cut your dose by a bit. Tyrosine is good for helping your brain run normally when you are coming off of amphetamines, opiates; it gives you more energy and motivation.
 
Tyrosine is very good after a binge, really normalizes you and gets rid of the desire to punch the world in the face.
 
I have found subjectively that tyrosine administration does increase the effects of amphetamine. Especially when you hit the plateau where taking more amphetamine does nothing. It is also worthy to note that it increases the undesirable peripheral effects just as much.
 
I would take l-tyrosine on off days, or like already said few hours before you take your dex. Some people (above) say that it increases the anxiety just as much like the high.
 
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