probably a dumb q, but does tram block other opiates??

[Hydroxymorphodone]

cause I took 300mgs of tram and 4 hours later I got my script for roxies and put two up my nose and it dont feel like it normally does...

 

[slowdive]

No. Tramadol is not a mu-antagonist at all.
It is purely a mu-agonist. It also releases serotonin, norepinphrine reuptake inhibitor, NMDA receptor antagonist, nicotonic acetylcholine receptor anagonist. It has two more actions in the brain, but don't remember them right off the top of my head.

Again. No. tramadol does not block the effect of opioids.

 

[Hydroxymorphodone]

maybe its just cause it elevated mood so much I didn't notice the effects as strongly. It was only a twenty mg dose

 

[K'd-OUT-in-AZ]

No, it doesn't block the effects of other opioids.

 

[digital_phreedom]

No. Tramadol is not a mu-antagonist at all.
It is purely a mu-agonist. It also releases serotonin, norepinphrine reuptake inhibitor, NMDA receptor antagonist, nicotonic acetylcholine receptor anagonist. It has two more actions in the brain, but don't remember them right off the top of my head.

Again. No. tramadol does not block the effect of opioids.

^^

5-HT2C receptor antagonist, and M1 and M3 muscarinic acetylcholine receptor antagonist

 

[phatass]

agree with the others, tramadol does not block other opiates

 

[kcajla3]

cause I took 300mgs of tram and 4 hours later I got my script for roxies and put two up my nose and it dont feel like it normally does...

Be wary of trams, I had a seizure from those and didn't feel it coming at all. Didn't stop me from finishing the script eventually, just had to be more careful. Take em with a benzo if you got em.

 

[slowdive]

Be wary of trams, I had a seizure from those and didn't feel it coming at all. Didn't stop me from finishing the script eventually, just had to be more careful. Take em with a benzo if you got em.

Sorry to hear about your seizure. I have been on tramadol for 7 years and have yet to have a seizure. I rarely go over 200mg in 24 hours, but I still think about a seizure sometimes. The risk may be overblown a bit, but I know there is a big risk over 400mg in 24 hours. Some experts recommend not to go over 300mg/24hour.

 

[kcajla3]

Sorry to hear about your seizure. I have been on tramadol for 7 years and have yet to have a seizure. I rarely go over 200mg in 24 hours, but I still think about a seizure sometimes. The risk may be overblown a bit, but I know there is a big risk over 400mg in 24 hours. Some experts recommend not to go over 300mg/24hour.

I was on more than the recommended dosage, and wasn't sleeping much either. It's hard to tell if you're prone to having one without an EEG, mine came back abnormal so I'm prone to them. I twitch like hell on trams too I guess that should have been a sign.