• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Prevention of headaches with NBOMe's

5HToInfinity

5HToInfinity

Bluelighter
Joined
Aug 20, 2012
Messages
234
It seems most of the NBOMe's that I've tried (25C, 25I, 25B) have a very high potential for generating very annoying post trip headaches that seem to last up to a day or so. The 2C's also have this property, but to a lesser extent, especially 2C-I in my experience. I'm wondering - are these headaches due to vasoconstriction? And if so, would vasodilators help prevent these headaches? And if not, what else can be done to avoid awful head throbbing 24h after the trip?
 
You wouldn't happen to administer these drugs intranasally by any chance?
 
Yes, usually due to the inconvenience of holding a solution in the mouth for 45 minutes and awful GI discomfort if any of it is swallowed. I suppose buccal administration reduces the headache side effect, but through what mechanism?
 
Strange though, shouldn't LSD and Psilocin prevent headhaches?
I thought Nbomes should work in a similar way about this problem, especially for the vasoconstrictor effect.
 
Strangely enough I've combined LSD with 25B-NBOMe and got a terrible headache the next day.
 
It's definitely the ROA. The drug kicks FUCKING hard and fast that way. Plugging would be your best bet but I have no idea of the best method for doing this safe and sterile. Could you lay a blotter? easier than the solution.
 
It seems staggering a dose nasally does no use in reducing headaches, so I doubt it has to do with the speed of absorption.
 
Nevertheless I agree that it is probably still related to the insufflation, not sure what else is different besides the pharmacokinetics. For example with MXE snorting gives me much more of an edgy ritalin like feeling while sublingually it is more plainly dissociative, relatively.

I too insufflated 25X compounds when I tried them since I have applied them to a mannitol carrier for that purpose. I got pretty bad vasoconstriction that made my feet so cold that it disturbed me having an enjoyable 'care free' experience. Not so much worry as discomfort though. I got this especially with 25D while 25C was still acceptable I guess. But the doses were low so it put me off proceeding to try NBOMe's. Later I realized that it is very possible that administering my powder sublingually will give me much better results.

Also there are different mechanisms for headaches or migraines or cluster headaches and they respond differently to different treatments. Small doses of caffeine are sometimes used for its vasoconstricting effect, apparently some types of headaches are a result from dilated blood vessels so it can go either way. Then there are tension headaches, mostly felt on the back of the head/neck or a bit behind the ears - sometimes a bit in the jaw... I don't think it has a lot to do with vein dilation as much as physical anxiety or perhaps blood pressure.

I think serotonin agonism is what makes psilocin LSD and probably other psychedelic suitable for particular forms of headaches, that would be the cluster headaches. Serotonergic action is what they have in common, I doubt it is as simple as vasodilation.

If you have different kinds of headaches the psychedelics don't help, and furthermore psilocin and LSD can have the opposite effect and produce nasty forms of headache in healthy individuals.

Also dilating your blood vessels without muddying the trip with other drugs can be difficult... I mean I tried L-arginine and it had little effect IIRC. So what else is there?

I say just try sublingual administration at a dose you have experience with and check the differences.
 
azzo said:
Strange though, shouldn't LSD and Psilocin prevent headhaches?
I thought Nbomes should work in a similar way about this problem, especially for the vasoconstrictor effect.
Click to expand...



IIRC this is through 5HT1a activation, which is lecss prevalent in the more selective NBOMes
 
azzo said:
Strange though, shouldn't LSD and Psilocin prevent headhaches?
I thought Nbomes should work in a similar way about this problem, especially for the vasoconstrictor effect.
Click to expand...
As others have stated headaches can be caused in many different ways. LSD is especially effective at alleviating as well as preventing a rare form of migraine called a cluster headache -- whose pain is said by mothers who experience them to rival that of childbirth. It may be that LSD achieves this effect through lessening the vasodilation that puts pressure on nerves, but the thing is it also prevents cluster headaches for up to many months, which of course far exceeds LSD's presence in the body, suggesting if LSD's vasoconstrictive effects are responsible for preventing cluster headaches it's through some longer term mechanism and not the same one that sometimes causes back and neck tension just for the duration of a trip. I've read that some migraine medicines target 5HT1a, but I don't think they have the same long term preventative effects as LSD, which implies something more going on than the effects of 5HT1a agonism alone.

I think I remember reading that vasodialators don't dilate blood vessels everywhere equally either, and even cause constriction in particular parts of the body where the same receptors have the opposite function. I've never experienced a headache from insufflation of 25C or I, but if others have then changing the ROA sounds like the most promising preventative, even if we have no idea why it works.
 
Solipsis said:
Also dilating your blood vessels without muddying the trip with other drugs can be difficult... I mean I tried L-arginine and it had little effect IIRC. So what else is there?
Click to expand...

Magnesium? I usually take 400mg of chelated magnesium halfway through my NBOMe trips, it does seem to help. I also like soaking in a bath with epsom salts at the end as it's wearing off (that's more for muscle tension though).

Niacin, capsaicin, and theobromine are also supposed to be good vasodilators. Out of those I've only tried theobromine once during a 25C trip, but I misremembered the suggested dosages I found online and took too much (100mg should be plenty, I took 4 times as much for some reason :|) and got uncomfortable chest pressure for a few hours. I'm going to have to try again sometime with the right dosage...

Applying a drop of lavender oil directly to the temples also seems to help with headaches. That could be placebo effect, though. (But it's a very pleasant smelling placebo nonetheless. :D)
 
Last edited:
psood0nym said:
As others have stated headaches can be caused in many different ways. LSD is especially effective at alleviating as well as preventing a rare form of migraine called a cluster headache -- whose pain is said by mothers who experience them to rival that of childbirth. It may be that LSD achieves this effect through lessening the vasodilation that puts pressure on nerves, but the thing is it also prevents cluster headaches for up to many months, which of course far exceeds LSD's presence in the body, suggesting if LSD's vasoconstrictive effects are responsible for preventing cluster headaches it's through some longer term mechanism and not the same one that sometimes causes back and neck tension just for the duration of a trip. I've read that some migraine medicines target 5HT1a, but I don't think they have the same long term preventative effects as LSD, which implies something more going on than the effects of 5HT1a agonism alone.

I think I remember reading that vasodialators don't dilate blood vessels everywhere equally either, and even cause constriction in particular parts of the body where the same receptors have the opposite function. I've never experienced a headache from insufflation of 25C or I, but if others have then changing the ROA sounds like the most promising preventative, even if we have no idea why it works.
Click to expand...

Yes i knew it was pretty complicated and still somehow speculative, i didn't know it was 'mainly' for 5HT1a instead of 5HT2 though.
I was trying to persuade my brother's GF to test with LSD or Mushrooms/4-Aco-DMT for her big problem with cluster headache instead of taking high doses of Nimesulide (Aulin) so often which are certainly most damaging in the long term.
My brother push her for using opiates saying she is not the type of person for psychedelics, but well i disagree for opiates because they don't solve the problem for long terms and there could be the chance of becoming addicted.
Some people are simply not so open-minded :)
Anyway i'm going pretty offtopic 8)
 
azzo said:
Yes i knew it was pretty complicated and still somehow speculative, i didn't know it was 'mainly' for 5HT1a instead of 5HT2 though.
I was trying to persuade my brother's GF to test with LSD or Mushrooms/4-Aco-DMT for her big problem with cluster headache instead of taking high doses of Nimesulide (Aulin) so often which are certainly most damaging in the long term.
My brother push her for using opiates saying she is not the type of person for psychedelics, but well i disagree for opiates because they don't solve the problem for long terms and there could be the chance of becoming addicted.
Some people are simply not so open-minded :)
Anyway i'm going pretty offtopic 8)
Click to expand...
Then say you'll give her a dose that she won't even feel, and do it. Even if she doesn't want to trip it may be that even sub-psychedelic doses of LSD or mushrooms will have a more beneficial effect than other medications. In such a case, she doesn't have to trip at all and still benefits from less pain if it works.
 
I get really bad headaches post 25i nbome. Tell me if my theory makes sense.

After being vasoconstricted during the trip (sometimes my leg muscles feel like burning cactus's) and when the trip is over the vasodilation rebound kicks in and the headache results from this almost sudden change.

Man my head aches so bad post trip it hurts to move.
I don't even get headaches normally.
 
Next time I'll experiment with a combination of L-Arginine, Magnesium and Cayenne pepper and report back.
 
Ibuprofen would work great. I have 750mg, and one did the trick for headaches.
 
You must log in or register to reply here.
Top