Prescribed Zoloft can someone explain this wiki quote?

[MikeRWK]

Sertraline is a moderate inhibitor of CYP2D6 and CYP2B6 in vitro.[79] Accordingly, in human trials it caused increased blood levels of CYP2D6 substrates such as metoprolol, dextromethorphan, desipramine, imipramine and nortriptyline, as well as the CYP3A4/CYP2D6 substrate haloperidol.[80][81][82] This effect is dose-dependent; for example, co-administration with 50 mg of sertraline resulted in 20% greater exposure to desipramine, while 150 mg of sertraline led to a 70% increase.[83][84] In a placebo-controlled study, the concomitant administration of sertraline and methadone caused a 40% increase in blood levels of the latter, which is primarily metabolized by CYP2B6.[85] Sertraline is often used in combination with stimulant medication for the treatment of co-morbid depression and/or anxiety in ADHD[86] Sertraline reduces amphetamine metabolism as a result of CYP2D6 inhibition.

Does this mean I will feel greater effects from codeine or less?

 

[MikeRWK]

I found my answer, codeine was a favorite of mine for a good buzz once in a while

Drugs that are inhibitors of CYP450 2D6 may interfere with the analgesic effect of codeine. The mechanism is decreased in vivo conversion of codeine to morphine, a metabolic reaction mediated by CYP450 2D6.

 

[shpongle1987]

When i was on zoloft i remember taking hydrocodones and oxys a few times and it was the strangest fucking thing....for the first hour you feel amazing then literally nothing...i never maintained a opiate high for more then one-1.5 hrs tops. Just my 2 cents.

 

[MikeRWK]

When i was on zoloft i remember taking hydrocodones and oxys a few times and it was the strangest fucking thing....for the first hour you feel amazing then literally nothing...i never maintained a opiate high for more then one-1.5 hrs tops. Just my 2 cents.

Yeah I used to pop 3 5/500 percs like every 6 months because they got me pretty high, I am weening off 150mg effexor for a week with 75mg effexor and 1mg clonazepam a day.I intend to get one more codeine high in before im switched to zoloft because i have them on hand where as finding percocet seems to be impossible at the moment.

 

[Rybee]

Not Zoloft but Effexor (Venlafaxine) contributed to the decline in my Codeine 'habit' - I wouldn't say it ruined it, but it certainly reduced the effects.

Perhaps a blessing in disguise, in hindsight.

 

[MikeRWK]

Not Zoloft but Effexor (Venlafaxine) contributed to the decline in my Codeine 'habit' - I wouldn't say it ruined it, but it certainly reduced the effects.

Perhaps a blessing in disguise, in hindsight.

I'm on an effexor taper right now to switch to zoloft because effexor isnt making any progress with my anxiety after 1.5-2 years.I'm hoping you're right and the effects are greater on zoloft.

 

[Doldrugs]

Definitely don't wait two years to switch if this doesn't work. A few months tops. Sometimes you need to try 20 or more different drugs to find out what helps. You're going to want to get through them quickly. Remember, you can always go back on if nothing else works. And if something has shitty side effects, get off and try something else!

Have you ever looked into mindfulness based meditation? For me, it was more helpful for anxiety than any medication I tried. Some of them worked, but not without intolerable side effects. I'm still on lexapro, though, which still helps.

 

[MikeRWK]

Definitely don't wait two years to switch if this doesn't work. A few months tops. Sometimes you need to try 20 or more different drugs to find out what helps. You're going to want to get through them quickly. Remember, you can always go back on if nothing else works. And if something has shitty side effects, get off and try something else!

Have you ever looked into mindfulness based meditation? For me, it was more helpful for anxiety than any medication I tried. Some of them worked, but not without intolerable side effects. I'm still on lexapro, though, which still helps.

It was improving at first but yeah, the anxiety/depression and the stupid NP I was seeing that was only going by a book would just raise my dose all of that combined had me fucked up.It was another doctor I went to see that decided we should try zoloft or lexapro I forget I was a nervous wreck the day I went in.Since I'm taking half my regualr dose of effexor to taper for a week to switch to the other med I already find it easier to sleep, the NP kept blaming it on weed even after I was off it for 2 months.I know some people take 4-6 months to sleep naturally after quitting but I knew it wasnt from weed.

 

[Doldrugs]

If your doctor doesn't listen to you, get a new doctor. Fuck that shit. Never continue taking something you don't want to take. Say "I'm gonna stop taking it whether you like it or not, tell me how to do it safely."

 

[MikeRWK]

If your doctor doesn't listen to you, get a new doctor. Fuck that shit. Never continue taking something you don't want to take. Say "I'm gonna stop taking it whether you like it or not, tell me how to do it safely."

Yeah I know man but its hard sometimes when you've got the anxiety creating doubts in you mind and the depression doesnt help either.Then there was my weed problem making me a chronic procrastinator, just going with the flow rolling through life like a tumbleweed.But I did it now and I'm willing to try a million different meds because I've got potential and I dont want to waste it.I already lost a lot of opportunities between girls and jobs because of this shit and I'm tired of it, I noticed a 'change' in me when I was 11-12 and didn't know what it was until I was 22-23.I'm 25 now and I still have time to make up for all those things I just need to find what works.


Kind of off topic but I find more so the older people will try one medication an then say none of them work even though they havent tried them or that they're all the same.If they were all the same you'd get the same pill whether you had a chest infection or your leg just got cut off.I also see a lot of people scared of medications they havent tried because they're 'addictive' I suggested a guy i went to school with go to the doc and get a benzo for his weed wd and he mentioned addiction so I straight told him "If you don't have the self control maybe you should just stick to weed".The dude was also smoking crack as early as grade 9 selling his super nintendo games lol.

 

[Doldrugs]

Yeah I hear you, man. Sometimes it's hard to push back. I've spent my share of appointments gripping the chair arms and staring at the floor.

I didn't start getting my shit together until I was the same age. Still not as together as I'd like, but I'm a lot better than I used to be. I'm able to leave the apartment, for one thing. And I actually get to feel happiness at least some of the time. I wish you the best of luck.

And I agree about how people view medication. One antidepressant or antianxiety pill doesn't work for them and they're sure it's all an evil conspiracy. Things are rarely that black and white.

 

[MikeRWK]

Yeah I hear you, man. Sometimes it's hard to push back. I've spent my share of appointments gripping the chair arms and staring at the floor.

I didn't start getting my shit together until I was the same age. Still not as together as I'd like, but I'm a lot better than I used to be. I'm able to leave the apartment, for one thing. And I actually get to feel happiness at least some of the time. I wish you the best of luck.

And I agree about how people view medication. One antidepressant or antianxiety pill doesn't work for them and they're sure it's all an evil conspiracy. Things are rarely that black and white.

Yeah at one point I couldn't talk on the phone, always thought people were judging or talking about me.If I was in a conversation where 3 or more people were talking I'd get overwhelmed and wouldnt be able to make any of it out it was just random garble.I always needed someone with me to feel somewhat calm, supermarkets clerks thought me and my friend were 'partners' since I would follow him through the checkout because I couldn't handle standing alone for 5 minutes.I've made improvement but theres more to be made an effexor just isnt doing it.

I was living in a beautiful house rent free but my mother made me move in with her and get a job since she owned the house, and that was a good thing to be honest.I probably would be on welfare going insane from not being able to buy enough weed to keep me good for the month if she hadn't done it.I wouldn't have went to a different doctor and for all I know I could have ended up doing something stupid because you can only handle so much mental stress before you break whether its real or in your head it's still the same.

I'm hoping the zoloft (im pretty sure its zoloft and not lexapro but like I said i was a wreck when I went in and have to go back tomorrow to get whatever it is.) is the one that fixes me.I'm not going to give up though or else I wont have a meaningful life.I don't want to be withdrawn always stressed out over nothing wishing I could live a normal (I know that word is subjective) life.I just want to reach my potential and not feel like im useless.I was also not moving out of the house especially sept/oct after my application for funding for a welding course got rejected that put me in some depression for months.

I would just stay in bed all day getting stoned and looking at things I wished I could afford or stuff I wished I could do.

 

[fipoch]

Hi Mike, I feel like I'm in the same page as you are. I've been having insomnia since I stopped taking weed in 2010. It's been driving me crazy. Everyday before going to bed, I'd stress up over ways of trying to get myself to fall asleep. Sometimes I can go on for days without going to sleep. I've been on luvox and xanax since 2011 until last year I decided to quit cold turkey and decided to go on without taking any medication after breaking up with my girlfriend of 2 years. I've been going to the gym ever since, every single and it has helped me a lot mostly on fighting anxiety amd depression. But still, the insomnia is there. Sometimes I get to sleep, sometimes I don't. My dreams are very vivid.

 

[Doldrugs]

I know it's a cliche, but don't give up. Just keep trying new stuff until it gets better. It's a constant battle but it's worth it. I never thought I'd be doing as good as I am now.

I've been on luvox and xanax since 2011 until last year I decided to quit cold turkey and decided to go on without taking any medication after breaking up with my girlfriend of 2 years.

That was incredibly dangerous and you're lucky you didn't pay for it with a major medical issue. Please, anyone reading this, taper properly from these kind of drugs. Ask your doctor how to do it.

 

[MikeRWK]

I should have updated everyone, during my effexor taper i noticed I was able to fall asleep easier and now that im on zoloft I get tired like a normal person and can sleep or fight it off if I want to.The doctor also prescribed me 15x1mg kpins to use as needed and I find myself needing them less and less.

In the last 2 days I've had so much motivation you'd think I was on stims.I spent like 3 hours plowing snow with the quad i pretty much had the whole yard plowed and tonight I spent a few hours fixing the railing on my parents stairs.Usually I'd just sit around and do fuckall I wouldn't have this much energy.I'm experiencing mild snri wd since switching because zoloft is an ssri and im on 50mg/day where i was on 150mg/day then tapered to 75mg/day effexor.It's getting less noticeable and if I'm busy i dont really notice.