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Pregabalin together with alprazolam

El_Toro

Bluelighter
Joined
Jul 23, 2006
Messages
411
Hello,

First of all forgive me if this question is not advanced enough, and feel free to move it to BDD.

I was wondering if Pregabalin, known to enhance slow wave sleep stages, would counteract the decriment in SWS affected by anxyolitic benzodiazepines (in my case, alprazolam/clonazepam).

Many thanks
 
El Toro--

For your question, I would probably recommend speaking to a doctor. If you are taking benzos that much for sleep that you feel it is affecting you, you are probably being perscribed them, so speaking to a doctor is a good idea.

For the other question, I don't think that melatonin will affect how much slow wave sleep you get while on benzos. In fact, most younger people with insomnia don't actually have a problem with melatonin levels (unless they have been taking a lot of excess melatonin that caused downregulation of receptors). Therefore, if melatonin would allow for the return of slow wave sleep on benzos, most young people on benzos would sleep quite well. (In general, melatonin gets decreased with age when the pineal gland gets calcified). However, if you are taking benzos for sleep, you could try getting off of them for a few days and see if melatonin by itself would work. It does decrease sleep onset time. However, if your melatonin levels are fine, supplementing with excess melatonin, (as long as your cycles are reglulated due to light), is bad. You never want to take more than .3mg of melatonin (a dose which you won't find in most stores), as higher doses increase melatonin levels to levels never seen in the brain and cause receptor downregulation--which is bad in the long term.) Too much of a good thing can be quite bad.

If losing long wave sleep is really a cause of concern, you should consider switching to GHB. GHB will both put you to sleep and give you great slow wave sleep. However, doctors won't perscribe it to the usual person with sleeping problems.
 
Thank you, although I was asking for pregabalin (Lyrica) and not melatonin. Moreover, I have read somewhere that benzos affect melatonin levels.

I have used GBL and I simply cannot use it to sleep as I only get 2 hours max of sleep, only to wake up alert at that time, having to redose another two times to get 6 hours of sleep. I do agree that it is refreshing sleep, but that dosing regimen leads to withdrawal fairly soon. I will not convert my batch to GHB for many reasons, although the most important one is, I do not see the reason in doing so.

I am not taking benzos that often though, maybe once or twice a week. The other days I get by swapping drugs or sleeping sans chemicals. However, I have as of lately woken up after 4 hours of sleep, and it is here that GBL plays an awesome role at helping me get an extra 2 hours which I would normally not get.

I would still appreciate any input on said mix, pregabalin and alprazolam for the implicited purpose.
 
Try another GABA-B agonist

Stuff other than GHB will cause GH release (and probably the SWS it's associated with). Baclofen (p-Cl-phenibut) does it really well, so I'm gonna guess phenibut probably does it, too. Phenibut has a much longer half-life, so you probably won't have the waking-up problem that makes GHB so ENTIRELY FRIGGIN' USELESS for sleep. Phenibut is also easy to get and pretty cheap. Withdrawal from it still sucks, though.

What about Neurontin? Isn't its mechanism similar to Lyrica?
 
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