• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Pregabalin (lyrica) and DXM

H

helium-4

Bluelight Crew
Joined
Aug 9, 2005
Messages
5,679
Location
In a house of smoke
I took 150mg of lyrica earlier this afternoon and I'm thinking about dosing some DXM tonight (~700mg). Should I wait till tomorrow to trip due to the lyrica still having some effects? Or should there be no issues with interaction.
 
Seems pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport (1), which I interpret as more GABA is being released which causes Ca cations release to be inhibited via GABAb receptors (g-protein linked). DXM being a NMDA antagonist would block ion channels also preventing the flow of Ca cations.

So wouldn't this result in no interaction as they are almost doing the same thing? Or do I not understand the pharmacology behind it.


I also took the the 150mg of pregabalin around 12:30pm and plan on dosing DXM around 11:00pm, 9.5 hours later. Pregabalin has a elimination half-life of 6 hours so I imagine the amount of pregabalin in my system will be very low, hardly enough to have a drastic effect on the drug. I'm not completely sure how half-life correlates to complete elimination of the drug though.

E: I calculated that there will be 56mg of pregabalin in my system by the time I dose. Correction, incorporating a 90% bio availability there will be 51mg of pregabalin in my system.

1 - http://www.rxlist.com/lyrica-drug.htm# clinical pharmacology, pg 6
 
Last edited:
Well, I think commonality on calcium release doesn't mean anything, really. Even if their actions would overlap there are many more things going on that affect the situation. But I venture the guess that we both don't actually understand the pharmacology behind it.
 
Pregabalin doesn't interact with cyp2d6 enzyme so there isn't any interferance with the metabolism of DXM. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

I'm having trouble finding the pharmacology of DXM anywhere to try and compare there mechanisms of action
 
You must log in or register to reply here.
Top