In March 2009 a 49 year old female (BMI 23.5) presented to the emergency department with upper gastrointestinal bleeding and haematemesis.
She was admitted for further investigation. Two days later, she was discovered with her eyes locked in a downward fixed stare with abnormal decerebrated posturing and a GCS of 9.
A search of her handbag revealed used blister packets of zopiclone, diazepam and pregabalin, which had been prescribed 5 days previously. The empty blisters would have amounted to 105mg, 245mg and 3150mg,respectively, if they had been ingested simultaneously.
Toxicology= Zopiclone(0.24mg/L) + Pregabalin (25.3mg/L)
The pathologist attributed the cause of death to Pregabalin and Zopiclone toxicity
JA said:We could use some more information and specifics...
do you know what the lethal dose of Pregablin is by itself?
it's hard to guage it from the mg per blood content as we only have about 5 litres of blood in our bodies
https://www.pfizer.com/sites/defaul...ta/LYRICA(pregabalin)capsules_30-jan-2017.pdfPregabalin:
Rat IV LD50 > 300 mg/kg
Mouse Oral LD50 > 5000mg/kg
Rat Oral LD50 > 5000mg/kg
https://www.pfizer.com/sites/defaul...ta/LYRICA(pregabalin)capsules_30-jan-2017.pdf
You still need to convert it as it's for rat/mouse, but I'd say the LD50 should be pretty high
Pregabalin
Mouse Oral LD50 >5000mg/kg
RatOralLD50 >5000mg/kg
so if it's 5000 mg/kg for a rodent, it'll be significantly higher for a human?