PreGABA- glutamine and B6

[swilow]

Okey dokey, I found a product that I find interesting. Basically capsules of glutamine and B6 and 'something else' more of a filler I believe. That lead me to thinking about that 'picmalion' stuff (GABA and b6) and how many people consider it rather worthless, since B6 is involved in the syn thesis of GABA not increasing BBB permeability....

I wonder how this combination would work at combatting anxiety? I, like many here, have very very chronic anxiety, though I am functional- just constantly going a million miles an hour- and am seeking more 'natural' routes to calming myself. GABA itself has alarming effects on me- (see Jamshyds thread on GABA), L-Theanine doesn't appear to do a great deal except when drunk as tea, and phenibut I don't really want to bother with. Also- pharmaceuticals have started to deeply scare me

So whats your opinion- would glutamine and B6 together help form GABA? I have reacted a bit nastily to glutmine* before so I don't feel like diving in...

*I constantly mix up the terms glutamine and glutamate; basically, I used the term glutamine as the amino acid here, and glutemate as the neurotrasnmitter. Please correct me on this if Im wrong...

Thanks.

PS. it is not related to pregabalin/lyrica

 

[MurphyClox]

I constantly mix up the terms glutamine and glutamate; basically, I used the term glutamine as the amino acid here, and glutemate as the neurotrasnmitter. Please correct me on this if Im wrong...

Not completely: Glutamate (...the neurotransmitter) is the salt of glutamic acid. This again is a proteinogenic amino acid, as is glutamine. Glutamic acid contains a carboxylic acid function, glutamine contains an amide...

To your question: I don't expect GABA-levels rising significantly. Just B6 + glutamine won't help it. If you nourish on healthy food, your B6- & glutamine-levels don't need any support and GABA is produced in sufficient quantity. I think, your body won't start this easily to synth more GABA but will rather hold a certain GABA-level constant (with daily fluctuations due to biorythm)

Peace! Murphy

 

[swilow]

^But for the recovering benzo addict, would it be of help? I guess the problem is more downregulation of receptros, not decrease in GABA though so probably not. Damn. It seems the only way to get thjose receptrors back online is to leave them to figure themselves out....

thankx murphycox

 

[shamus]

Glutamate itself (given a high enough dosage) is excitotoxic.

Think MSG headaches?


It is of course a precursor to GABA, but I don't think the inhibitory effects of the consequential GABA would outweigh the activity induced by glutamate (& possibly more NTs that use glutamate as a precursor?).

 

[NeuronalPerception]

This is where glutamate analogs like Theanine are useful which do not convert into Glutamate/Glutamine but do raise GABA levels and even has antagonist effects on glutamate receptors.

 

[MurphyClox]

^But for the recovering benzo addict, would it be of help[1]? I guess the problem is more downregulation of receptros, not decrease in GABA though so probably not. Damn. It seems the only way to get thjose receptrors back online is to leave them to figure themselves out[2]....

thankx murphycox[3]

[1]No IMO.
[2]Even if it's hard to bear but that would be the best idea. You're most probably right.
[3]It's Clox, not Cox, fella!

Glutamate itself (given a high enough dosage) is excitotoxic.
It is of course a precursor to GABA, but I don't think the inhibitory effects of the consequential GABA would outweigh the activity induced by glutamate (& possibly more NTs that use glutamate as a precursor?).

They wouldn't for sure. The intoxication with glutamate is also called "china restaurant syndrome", coming with headaches, flushing, sweating, just to mention the harmless ones. Vitamine B6 is said to prevent symptoms.

Murphy