cannibalsnail
Bluelighter
- Joined
- Sep 18, 2011
- Messages
- 320
Its a mixed D2/3/4 agonist with preferential binding to D3. Drugs I am interested in are Stimulants (DRI + DRA), Psychedelics and Cannabis.
My theory regarding stimulants is that it would lower binding at D2 type receptors due to Pramipexoles higher binding affinity than DA. Increased D1 binding would make them more euphoric maybe?
Psychedelics sensitize D2 receptors so does this mean higher D2 activity or unchanged?
Cannabis interactions with Dopamine neurones is unknown to me.
Any thoughts?
My theory regarding stimulants is that it would lower binding at D2 type receptors due to Pramipexoles higher binding affinity than DA. Increased D1 binding would make them more euphoric maybe?
Psychedelics sensitize D2 receptors so does this mean higher D2 activity or unchanged?
Cannabis interactions with Dopamine neurones is unknown to me.
Any thoughts?