Stimulants PPAP + Cocaine + Ketamine?

[millzy]

Hello Bluelighters.

New member here with over 30 years experience with all kinds of substances. Looking for some insights on possibly combining PPAP with cocaine and ketamine.

I am a fan of PPAP as a stim enhancer. I most recently combined it with cyclazadone, which was pretty nice. This got me wondering if PPAP will pair with more "serious" drugs. But I'm not sure if the combo I have in mind is safe.

I do cocaine a few times a year. 2-3 grams over the course of a weekend. I sometimes take ketamine on the comedown at holing doses. I have a weekend like this coming up and I'm curious about adding PPAP to the mix.

Since PPAP enhances dopamine release, and cocaine and ketamine both work off of dopamine, my guess is that there could be synergies. But I'm not sure if it's safe. Last thing I want to do is hurt myself, my partner, and/or waste my stuff.

Any thoughts?

Thanks in advance.

 

[Skorpio]

How much does it potentiate the cyclazodone? Would you feel comfortable with that level of potentiation for the cocaine session you mentioned?

If you do this, go slow and it would be best to pick one or the other to mix it with so that the interactions are more predictable. If you are going to be having a wild weekend, it might not be the best environment to try a new combo.

 

[millzy]

The way PPAP works from my layperson's understanding is that it causes extra dopamine to be released whenever it would be released.

With cyclazadone, it makes the good effects, like the body high and enhanced focus, more apparent without adding to any side effects so you don't have to take as much cyclazadone.

I could see how PPAP could make a cocaine session even better, but I don't carefully measure my doses like I do with cyclazadone, so it could make the session uncomfortable if not dangerous. Same for ketamine.

I'll skip it.

Thanks.

 

[emkee_reinvented]

The way PPAP works from my layperson's understanding is that it causes extra dopamine to be released whenever it would be released.

With cyclazadone, it makes the good effects, like the body high and enhanced focus, more apparent without adding to any side effects so you don't have to take as much cyclazadone.

I could see how PPAP could make a cocaine session even better, but I don't carefully measure my doses like I do with cyclazadone, so it could make the session uncomfortable if not dangerous. Same for ketamine.

I'll skip it.

Thanks.

Good news this sounds as if it could be the perfect ADHD medication.
Taken solely, instead of dextro-Amphetamine. Active when needed.

"The therapeutic index for PPAP in animal models is greater than that of amphetamine while producing comparable improvements in learning, retention, and antidepressant effects. [Wiki]". BPAP being even stronger/ broader, and effecting Serotonine.

Are they safer then Stimulant s they look more suitable,
if they selectively enhance the release.

 

[Skorpio]

The way PPAP works from my layperson's understanding is that it causes extra dopamine to be released whenever it would be released.

With cyclazadone, it makes the good effects, like the body high and enhanced focus, more apparent without adding to any side effects so you don't have to take as much cyclazadone.

I could see how PPAP could make a cocaine session even better, but I don't carefully measure my doses like I do with cyclazadone, so it could make the session uncomfortable if not dangerous. Same for ketamine.

I'll skip it.

Thanks.

I remember reading about PPAP/BPAP ages ago and almost feeling like their mechanisms of action were too good to be true (see tianeptine being classified as a “selective serotonin reuptake enhancer” before everybody found out it was an opioid). This is very interesting to me, what effects would you say PPAP has on its own (or even with something like caffeine which potentiates dopamine signaling rather than inducing release).

I would love to see some research on these “catecholaminergic/monoaminergic activity enhancers” at the molecular level. They were all created by the Hungarian pharmacologist József Knoll, and have mainly been studied by him and his students. This is the first report I’ve heard of their effects in the wild and very cool indeed.

 

[millzy]

PPAP is pretty cool. By itself there's some light stimulation and a nice body high, especially when taken intranasally. It reminds me of the 2C that's known for its mildness. 2C-C maybe? Think that but even milder.

Where PPAP shines is when it's taken with complementary substances. I've taken it with RGPU-95 and cyclazadone with good effects. I've heard it goes well with prescription stimulants like adderall, ritalin, and vyvanse, but I don't have any firsthand experience to share about those. Only taken adderall and ritalin on their own.

12mg of cyclazadone with about 36mg of PPAP produced a pleasant, strong, and managable stimulant high that didn't have any of the unpleasant side effects that are reported from taking too much cyclazadone, like extreme anxiety.

This experience is what made me curious about trying PPAP with cocaine and ketamine, but as I mentioned, after thinking it through I feel like the risks outweigh any potential rewards.

Thanks again by the way for helping me think this through.

 

[Leprechaun]

This sounds interesting. I wonder what the effect is when combined with running, yoga, weight lifting. Which all increase monoamine levels in the brain.

 

[sludgekatana]

Just got some and decided to combo about 30mg PPAP with several other of my daily drivers... including quite a large dose of cyclazadone (about 75mg total, although only some of it was sublingual, I took the rest orally). I decided to plug the PPAP because I hate snorting anything and it's the HCl formulation so it's pretty caustic. Plugging it seems like the way to go, it's not uncomfortable at all. I also plugged 100mg O-DSMT shortly after, although I should note my tolerance to O-DSMT is pretty high right now. I also took about 800mg Agmatine at about 8 hours ago. It's been a little over an hour since I took the Cyclazadone sublingual + 30mg PPAP rectal, and I can definitely feel some light and pleasant euphoria coming on. I don't feel tweaky or anxious. This is quite pleasant so far, will come back here to update later.

Oh, also, has anyone tried combo'ing PPAP with stronger stims, like amphetamine? Can't find many reports of anyone doing that. I definitely want to try, but I'd like to avoid excessive dopamine release because that often leads me to binge which I'm really trying to get out of the habit of. I'm hoping maybe it would let me take less amphetamine for a more euphoric effect without pushing too much dopamine and putting me in the passenger seat of a binge, if you get what I mean

EDIT1: Took a tiny bit of etizolam to deal with any anxiety from the quite high dose of Cyclazadone. Also sublingual. I really am a polysubstance addict I guess lol

 

[Leprechaun]

Have combined PPAP with Amphetamine surface with mixed results.

Combining it with cyclazadone and n-methyl -cyclazadone is much better.

Combining with phenylpiracetam was strange and unpleasant.

 

[Syntherize]

I remember reading about PPAP/BPAP ages ago and almost feeling like their mechanisms of action were too good to be true (see tianeptine being classified as a “selective serotonin reuptake enhancer” before everybody found out it was an opioid). This is very interesting to me, what effects would you say PPAP has on its own (or even with something like caffeine which potentiates dopamine signaling rather than inducing release).

I would love to see some research on these “catecholaminergic/monoaminergic activity enhancers” at the molecular level. They were all created by the Hungarian pharmacologist József Knoll, and have mainly been studied by him and his students. This is the first report I’ve heard of their effects in the wild and very cool indeed.

Tianeptine is an old tricyclic antidepressant with some opioid effects. The term opioid pertains to ANY drug that acts on the opioid receptors (mu, delta, kappa, sigma) including something such as Salvia divinorum which is a kappa opioid receptor agonist without ANY classical mu opioid receptor-like activity. Just because something has opioid effects doesn’t necessarily make it akin to morphine or heroin for that matter. The word “opiate” is used for naturally occurring opiates derived directly from the poppy (morphine, codeine, theibane, etc) while the term “opioid” defines ANY substance with some form of opioid activity including things like the casomorphins present in cheese and loperamide as well among many other things.

 

[millzy]

Have combined PPAP with Amphetamine surface with mixed results.

Combining it with cyclazadone and n-methyl -cyclazadone is much better.

Combining with phenylpiracetam was strange and unpleasant.

Any experience with PPAP and Adderall?

I have some extended release that I plan on taking at some point (as instant release after crushing them up), and am entertaining the idea of taking them with PPAP to make the experience more recreational. While I think combining PPAP with cocaine and ketamine seems unsafe as we discussed in this thread previously, PPAP and Adderall would seem like a good combo. I've seen some reports about it but have not yet taken the plunge.

Since it's been mentioned in this thread, my two cents is to avoid Tianeptine altogether. Tianeptine seems extremely dangerous with a high potential for dependency and terrible withdrawal.

 

[Dr. Trismegistus]

Hello Bluelighters.

New member here with over 30 years experience with all kinds of substances. Looking for some insights on possibly combining PPAP with cocaine and ketamine.

I am a fan of PPAP as a stim enhancer. I most recently combined it with cyclazadone, which was pretty nice. This got me wondering if PPAP will pair with more "serious" drugs. But I'm not sure if the combo I have in mind is safe.

I do cocaine a few times a year. 2-3 grams over the course of a weekend. I sometimes take ketamine on the comedown at holing doses. I have a weekend like this coming up and I'm curious about adding PPAP to the mix.

Since PPAP enhances dopamine release, and cocaine and ketamine both work off of dopamine, my guess is that there could be synergies. But I'm not sure if it's safe. Last thing I want to do is hurt myself, my partner, and/or waste my stuff.

Any thoughts?

Thanks in advance.

Post synthesis you would have to run some discovery the n compound. Just hypothetically speaking.

 

[HealingEnergy14]

Just got some and decided to combo about 30mg PPAP with several other of my daily drivers... including quite a large dose of cyclazadone (about 75mg total, although only some of it was sublingual, I took the rest orally). I decided to plug the PPAP because I hate snorting anything and it's the HCl formulation so it's pretty caustic. Plugging it seems like the way to go, it's not uncomfortable at all. I also plugged 100mg O-DSMT shortly after, although I should note my tolerance to O-DSMT is pretty high right now. I also took about 800mg Agmatine at about 8 hours ago. It's been a little over an hour since I took the Cyclazadone sublingual + 30mg PPAP rectal, and I can definitely feel some light and pleasant euphoria coming on. I don't feel tweaky or anxious. This is quite pleasant so far, will come back here to update later.

Oh, also, has anyone tried combo'ing PPAP with stronger stims, like amphetamine? Can't find many reports of anyone doing that. I definitely want to try, but I'd like to avoid excessive dopamine release because that often leads me to binge which I'm really trying to get out of the habit of. I'm hoping maybe it would let me take less amphetamine for a more euphoric effect without pushing too much dopamine and putting me in the passenger seat of a binge, if you get what I mean

EDIT1: Took a tiny bit of etizolam to deal with any anxiety from the quite high dose of Cyclazadone. Also sublingual. I really am a polysubstance addict I guess lol

"It's pretty caustic, let me put this up my asshole instead of my nose."

A thought pattern that has never seemed logical to me.

 

[Esperighanto]

Just out of curiosity, how would you characterize cyclazodone and PPAP?

 

[Dr. Trismegistus]

Hello Bluelighters.

New member here with over 30 years experience with all kinds of substances. Looking for some insights on possibly combining PPAP with cocaine and ketamine.

I am a fan of PPAP as a stim enhancer. I most recently combined it with cyclazadone, which was pretty nice. This got me wondering if PPAP will pair with more "serious" drugs. But I'm not sure if the combo I have in mind is safe.

I do cocaine a few times a year. 2-3 grams over the course of a weekend. I sometimes take ketamine on the comedown at holing doses. I have a weekend like this coming up and I'm curious about adding PPAP to the mix.

Since PPAP enhances dopamine release, and cocaine and ketamine both work off of dopamine, my guess is that there could be synergies. But I'm not sure if it's safe. Last thing I want to do is hurt myself, my partner, and/or waste my stuff.

Any thoughts?

Thanks in advance.

PPAP is being trialed for ADD & ADHD and as an antidepressant in few different countries.

 

[Dr. Trismegistus]

Just out of curiosity, how would you characterize cyclazodone and PPAP?

A prodrug stimulant/antidepressant

 

[Esperighanto]

A prodrug stimulant/antidepressant

I guess I meant the question in a more experiental sense, as opposed to pharmacokinetic, but I see where you're coming from.

 

[millzy]

Just out of curiosity, how would you characterize cyclazodone and PPAP?

You don't get the euphoria of recreational stims but it has a nice body high that lasts about 5 hours. It kills your appetite for about a day after. Very functional.

I took it to have enough energy to socialize at a small music event and it worked perfectly for what I needed it for. I'd try it in a more intimate setting or if I had a lot of physical work to do or a long drive. There are better stims out there for recreational use.