Stimulants PPAP + Cocaine + Ketamine?

[millzy]

Hello Bluelighters.

New member here with over 30 years experience with all kinds of substances. Looking for some insights on possibly combining PPAP with cocaine and ketamine.

I am a fan of PPAP as a stim enhancer. I most recently combined it with cyclazadone, which was pretty nice. This got me wondering if PPAP will pair with more "serious" drugs. But I'm not sure if the combo I have in mind is safe.

I do cocaine a few times a year. 2-3 grams over the course of a weekend. I sometimes take ketamine on the comedown at holing doses. I have a weekend like this coming up and I'm curious about adding PPAP to the mix.

Since PPAP enhances dopamine release, and cocaine and ketamine both work off of dopamine, my guess is that there could be synergies. But I'm not sure if it's safe. Last thing I want to do is hurt myself, my partner, and/or waste my stuff.

Any thoughts?

Thanks in advance.

 

[Skorpio]

How much does it potentiate the cyclazodone? Would you feel comfortable with that level of potentiation for the cocaine session you mentioned?

If you do this, go slow and it would be best to pick one or the other to mix it with so that the interactions are more predictable. If you are going to be having a wild weekend, it might not be the best environment to try a new combo.

 

[millzy]

The way PPAP works from my layperson's understanding is that it causes extra dopamine to be released whenever it would be released.

With cyclazadone, it makes the good effects, like the body high and enhanced focus, more apparent without adding to any side effects so you don't have to take as much cyclazadone.

I could see how PPAP could make a cocaine session even better, but I don't carefully measure my doses like I do with cyclazadone, so it could make the session uncomfortable if not dangerous. Same for ketamine.

I'll skip it.

Thanks.

 

[emkee_reinvented]

The way PPAP works from my layperson's understanding is that it causes extra dopamine to be released whenever it would be released.

With cyclazadone, it makes the good effects, like the body high and enhanced focus, more apparent without adding to any side effects so you don't have to take as much cyclazadone.

I could see how PPAP could make a cocaine session even better, but I don't carefully measure my doses like I do with cyclazadone, so it could make the session uncomfortable if not dangerous. Same for ketamine.

I'll skip it.

Thanks.

Good news this sounds as if it could be the perfect ADHD medication.
Taken solely, instead of dextro-Amphetamine. Active when needed.

"The therapeutic index for PPAP in animal models is greater than that of amphetamine while producing comparable improvements in learning, retention, and antidepressant effects. [Wiki]". BPAP being even stronger/ broader, and effecting Serotonine.

Are they safer then Stimulant s they look more suitable,
if they selectively enhance the release.

 

[Skorpio]

The way PPAP works from my layperson's understanding is that it causes extra dopamine to be released whenever it would be released.

With cyclazadone, it makes the good effects, like the body high and enhanced focus, more apparent without adding to any side effects so you don't have to take as much cyclazadone.

I could see how PPAP could make a cocaine session even better, but I don't carefully measure my doses like I do with cyclazadone, so it could make the session uncomfortable if not dangerous. Same for ketamine.

I'll skip it.

Thanks.

I remember reading about PPAP/BPAP ages ago and almost feeling like their mechanisms of action were too good to be true (see tianeptine being classified as a “selective serotonin reuptake enhancer” before everybody found out it was an opioid). This is very interesting to me, what effects would you say PPAP has on its own (or even with something like caffeine which potentiates dopamine signaling rather than inducing release).

I would love to see some research on these “catecholaminergic/monoaminergic activity enhancers” at the molecular level. They were all created by the Hungarian pharmacologist József Knoll, and have mainly been studied by him and his students. This is the first report I’ve heard of their effects in the wild and very cool indeed.

 

[millzy]

PPAP is pretty cool. By itself there's some light stimulation and a nice body high, especially when taken intranasally. It reminds me of the 2C that's known for its mildness. 2C-C maybe? Think that but even milder.

Where PPAP shines is when it's taken with complementary substances. I've taken it with RGPU-95 and cyclazadone with good effects. I've heard it goes well with prescription stimulants like adderall, ritalin, and vyvanse, but I don't have any firsthand experience to share about those. Only taken adderall and ritalin on their own.

12mg of cyclazadone with about 36mg of PPAP produced a pleasant, strong, and managable stimulant high that didn't have any of the unpleasant side effects that are reported from taking too much cyclazadone, like extreme anxiety.

This experience is what made me curious about trying PPAP with cocaine and ketamine, but as I mentioned, after thinking it through I feel like the risks outweigh any potential rewards.

Thanks again by the way for helping me think this through.