-
BDD Moderators: Keif’ Richards
Potentiating the serotoninegenic effects of (lis) or Dextro Amphetamine
- Thread starter Renz Envy
- Start date
nAON
Bluelight Crew
Wouldn't directly influence it, but 5-HTP could help with this (just be sure not to take any within a 24h period of any stimulants)
I can't see there being a supplement which would increase the amount of serotonin released by amphetamines unless you are already serotonin depleted and want to boost it back to normal levels, and even then I am not sure if any would actually make a significant difference. Why is it you are trying to do this?
Benzos won't counteract serotonin syndrome unfortunately, I imagine that was nAON's concern..
Benzos won't counteract serotonin syndrome unfortunately, I imagine that was nAON's concern..
ErgicMergic
Bluelighter
Is dextroamphetamine even significantly serotonergenic? I thought it had very low activity at the 5-HT receptors, rather acting mostly with NE and DA receptors, at a 1:1 ratio (compared to 5:1 with l-amp). As far as I know, only methamphetamine is significantly serotonergenic, hence its higher level of neurotoxicity and more relaxed, euphoric, and sedating high compared to d-amp.
Last edited:
Cane2theLeft
Bluelight Crew
- Joined
- Jun 21, 2008
- Messages
- 12,673
^ according to one study cited on this university site, 'methamphetamine promoted the release of serotonin at a rate 3x that of amphetamine'.
I found another article discussing the role that serotonin has in the effects of amphetamine (especially in naive users) and here are a couple excerpts -
Lastly, sorry to be pedantic but after 2 different ways the term was misspelled here, I wanted to point out that when a drug has properties that affect serotonin levels it is described as serotonergic.
I found another article discussing the role that serotonin has in the effects of amphetamine (especially in naive users) and here are a couple excerpts -
This work is the first demonstration of the acute effects of psychostimulants on excitatory synaptic transmission in the VTA. We report that amphetamine produces a rapid and reproducible decrease in excitatory synaptic transmission onto VTA neurons in slices from drug-naı̈ve animals. In general, previous work on psychostimulant action has focused on dopaminergic mechanisms; our results demonstrate that psychostimulant-mediated release of serotonin importantly modulates excitatory synaptic transmission in the reward pathway.
...
It will be particularly interesting to test whether the inhibitory effects of an initial exposure to amphetamine will change during subsequent drug exposures, because evidence supports the idea that the effects of amphetamine are altered with repeated exposure.
...
In conclusion, the present experiments demonstrate that amphetamine substantially depresses glutamatergic synaptic transmission to VTA cells via serotonin receptor activation. Our results suggest that serotonin is an important modulator of excitatory drive to VTA neurons and that a rapid early effect of psychostimulant exposure is release of this modulator. These experiments emphasize the importance of serotonergic systems in the complex modulation of elements in the reward pathway and provide new insight into the cellular effects of a drug abused by humans.
...
It will be particularly interesting to test whether the inhibitory effects of an initial exposure to amphetamine will change during subsequent drug exposures, because evidence supports the idea that the effects of amphetamine are altered with repeated exposure.
...
In conclusion, the present experiments demonstrate that amphetamine substantially depresses glutamatergic synaptic transmission to VTA cells via serotonin receptor activation. Our results suggest that serotonin is an important modulator of excitatory drive to VTA neurons and that a rapid early effect of psychostimulant exposure is release of this modulator. These experiments emphasize the importance of serotonergic systems in the complex modulation of elements in the reward pathway and provide new insight into the cellular effects of a drug abused by humans.
http://www.jneurosci.org/content/19/22/9780.long
Lastly, sorry to be pedantic but after 2 different ways the term was misspelled here, I wanted to point out that when a drug has properties that affect serotonin levels it is described as serotonergic.