Diamorphazepam
Greenlighter
- Joined
- Mar 15, 2015
- Messages
- 48
I'm curious to find out potentiates for benzos.
https://en.wikipedia.org/wiki/CYP3A4
Theres are the Inhibitors are inducers for a bunch of substrates including Xanax and Valium but not temazepam which depends on 3YP3A4.
Heres are some inhibitors:
Fluoxetine (Prozac)
Cimetidine
Ranitidine this wasn't listed (sp?)
Buprenorphine
MIlk Thistle
White grapefruit juice
Proton Pump Inhibitors including Nexium (Esomeprazole)
Im assuming if anything the Nexium out of the PPIs would be most effective.. A good atleast 40mg dose before doing ya benzo.
http://www.clevelandclinicmeded.com/medicalpubs/pharmacy/julyaugust2001/esomeprazole.htm
https://www.google.com.au/url?sa=t&...PI.pdf&usg=AFQjCNH0ms8YniGja7rSGE1vhPndOCD77g
45% increased elimination rate and increased peak rate for Valium it says after Nexium.
That's actually that's a huge potentiation!!
I did my homework and there is no significant reuduced elimination rate for temazepam because it is not dependent 3YP3A4 enzyme like diazepam is and I haven't researched about Xanax yet.
Ive only really looked up the Nexium on Valium, Temaze and Xanax. If anyone has any info about any more about any or the inhibitors with different benzos that would be great. Thanks
https://en.wikipedia.org/wiki/CYP3A4
Theres are the Inhibitors are inducers for a bunch of substrates including Xanax and Valium but not temazepam which depends on 3YP3A4.
Heres are some inhibitors:
Fluoxetine (Prozac)
Cimetidine
Ranitidine this wasn't listed (sp?)
Buprenorphine
MIlk Thistle
White grapefruit juice
Proton Pump Inhibitors including Nexium (Esomeprazole)
Im assuming if anything the Nexium out of the PPIs would be most effective.. A good atleast 40mg dose before doing ya benzo.
http://www.clevelandclinicmeded.com/medicalpubs/pharmacy/julyaugust2001/esomeprazole.htm
https://www.google.com.au/url?sa=t&...PI.pdf&usg=AFQjCNH0ms8YniGja7rSGE1vhPndOCD77g
45% increased elimination rate and increased peak rate for Valium it says after Nexium.
That's actually that's a huge potentiation!!
I did my homework and there is no significant reuduced elimination rate for temazepam because it is not dependent 3YP3A4 enzyme like diazepam is and I haven't researched about Xanax yet.
Ive only really looked up the Nexium on Valium, Temaze and Xanax. If anyone has any info about any more about any or the inhibitors with different benzos that would be great. Thanks
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