Stimulants Potential Low Dose Shrooms when on stable high dose Methylphenidate

[KurtAurelius]

Hi all,

I may be taking a 0.5-0.75g or so of shrooms at some point.. and I’m prescribed 77mg daily Methylphenidate (72mg Concerta and a 5mg IR)

I’m not looking to fully trip and have significant visual alteration and to really shatter my perceptions.

I intend to mirror when I previously have enjoyed a low dose but not a micro amount that results in very clear results cognitively and consciously.

A stillness without my usual rampant perspective..

In order to totally eliminate any interaction I could obviously just abstain my use of Methylphenidate but I worry that it may affect the experience I have.

I know I’m talking about a baby dose of shrooms but

1. I have been previously quite sensitive (but with fantastic experiences but before being on Meds) and

2. With how long daily I’ve been on Methylphenidate (2-3 months) I assume I will notice an abrupt shift in my presentation due to now having down-regulated receptors.

I’ve done some lazy skimming on Shrooms active metabolite (Pslicoin) if that’s even still true lol as that’s from my memory and I can see the bindings for DAT and NET are very high numbers but meaning very little activity at those sites.

Methylphenidate having mainly DAT and NET with a tiny bit of 5-HT1A and 5-HT2B at negligible levels of binding really..

There’s crossover with all of those sites, but with Methylphenidate and Pslicoin having interchangeable values, I.e one being a strong binder when the other is not it doesn’t concern me thatttt much?

I can see I may be over thinking this lol.

I had the Idea to use a lower dose of Methylphenidate to largely keep me at homeostasis, and to allow some space for the shrooms. (Just 54mg concerta)

I couldn’t find much online, even with using brave which doesn’t filter out harm reduction lol.

So sorry in advance for the extra thread.

 

[ĐmantuNJofra]

You should be ok maybe a bit anxiety but that is part of the proccess, as for taking break from mph you can take together after tolerance is lower so the psychedelic effect is combined with dopamine and noradrenaline energy as shrooms often makes one feel chill or chatatonic

 

[TheFunkeeJunkee]

If you have been on methylphenidate for a long period of time and are stable on that dose then I wouldn't be concerned about it seriously interfering with your trip, especially considering the dose is low. I wouldn't recommend you skip doses because this could actually provoke anxiety as your body and brain are used to methylphenidate.

 

[Dextro .45]

On it now…..perfectly fine. Shrooms first…..2 gram light dose empty stomach , 3h into it……Methadone 50mg (Opioid Narcotic) and Ritalin (Methylphenidate) 30-50mg IR in long lines …..clean water wet entire nasal pathway, HCL water soluble salts, aids absorption from nasal pathway rich in blood vessels , fast onset, 5-10 min peak levels approx

Overall pleasant experience…..the Psilocybin 2,000mg 3h earlier is still active and mellow in the background, newly introduced Opioids & Dopaminergic Stimulants is a safe, energizing, mood-boosting, euphoric Dopamine & Endorphines significantly increases and is very pleasurable & therapeutic

Diclazepam 2-3mg was also added 1h ago ……which has 3 active benzo metabolites, all licensed drugs currently

Diclazepam (2-Chloro-Diazepam) metabolizes into Delorazepam 78h+ half-life peaking in 48h then finally metabolizing into Lorazepam (Ativan)

 

[drewbocop]

Go for it. Stop thinking so much. (I realize this is a harm reduction forum but come on)

 

[Opana313]

This is a natural worry when combining any drugs. Mckenna said it was his only rule for the most part, not to mix drugs, because WAY less is known about that pharmacology especially with everyone being different.

BUT .5 basically says alot to me..I don't see any issues arising and I have mixed many many things in ridiculously high doses.

I remember watching Hamilton tripping ballz on Ayahuasca needing to pop his prescribed Ritalin.

 

[JitteryKitteryDoo]

Let us know how it goes.

 

[Satori446]

I have a simular kind of issue. Im on a l9w dose of Risperidone. 1mg in morning, 2 at night. I have the opportunity to get a couple grams of shrooms and I was wondering if I take like half a gram and hold off on my rispedal for a day while I take them will that be ok. Im not really looking to trip just wanna try and microdose for mental health reasons. I do not know the pharmalogicly of it all thats why im here on Bluelight. To learn before I do. Maybe im posting in wrong thread if I am I apologize