synergistic.affect
Greenlighter
This is my first thread. I am writing it, not because i claim to have tons of info on the dangers of mixing new RC's, but more so because I, as well as anybody that has even the slightest inkling of pharmacological knowledge, know that mixing some of these drugs no doubt can and will have horrible consequences in the near or distant future.
It is very alarming the way so many give no thought to these drug combos or think them to be harmless because thier heart didn't burst the first 2 times.
So what i would like to do is start this thread for people to contribute known or speculated info (please be clear which is which) about what some of these combos might do.
For example: does anyone know why Tramadol mixes so dangerously with most RC's? I know it is probably trams re-uptake inhibition but can anyone expand on that? Are there other drugs that are comparable to tramadol where similar warnings might extend?
Or: Does anyone know if all drugs with ssri properties uniformly inhibit 5ht reuptake including the dreaded 5ht(is it 2a) receptor that underlies the heart valve damage from fenphen and 4-fa relatives?
there is a wealth of knowledge on this board. these RC's are too new in a lot of cases. but looking at the info we can find, sharing knowledge we have, attempting to extrapolate info from similar compounds, etc. would likely go a long way in harm reduction. All in all, im hoping we, as a community, can start highlighting the underlying mechanisms that drug-on-drug interactions can harm or kill through. A lot of these RC's work on the same receptors. Let's see if we can't comprehensively organize some data on this subject.
Thanks
It is very alarming the way so many give no thought to these drug combos or think them to be harmless because thier heart didn't burst the first 2 times.
So what i would like to do is start this thread for people to contribute known or speculated info (please be clear which is which) about what some of these combos might do.
For example: does anyone know why Tramadol mixes so dangerously with most RC's? I know it is probably trams re-uptake inhibition but can anyone expand on that? Are there other drugs that are comparable to tramadol where similar warnings might extend?
Or: Does anyone know if all drugs with ssri properties uniformly inhibit 5ht reuptake including the dreaded 5ht(is it 2a) receptor that underlies the heart valve damage from fenphen and 4-fa relatives?
there is a wealth of knowledge on this board. these RC's are too new in a lot of cases. but looking at the info we can find, sharing knowledge we have, attempting to extrapolate info from similar compounds, etc. would likely go a long way in harm reduction. All in all, im hoping we, as a community, can start highlighting the underlying mechanisms that drug-on-drug interactions can harm or kill through. A lot of these RC's work on the same receptors. Let's see if we can't comprehensively organize some data on this subject.
Thanks
