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Pot & Effexor caused seratonin syndrome!

I'm more suprised to hear that effexor actually works on some people... I took it for a period, just made me sick, gave me migraines and limp dick. I've known a few other people that took it and 9 out of 10 said that it didn't work well for them either.

Thankfully I don't have any negative effects from smoking with my prozac script.
 
Strangely, Venlafaxine is a common cause of serotonin syndrome.

Get a load of this paper. Delta 9-THC (I know they call it D1, but they're the same thing), inhibits the utpake of serotonin with an affinity of around 20µM... but that's around 1000 times lower than its ~50nM affinity for CB1... yet, I find it resonable to believe that THC gets up to around 1µM in the plasma of very high people, so it might get even a bit higher than that in the brain, which could conceivabley lead to a good degree of serotonin reuptake inhibition (around 10% by my calculations, assuming 2x higher in brain).

Just an idea... I've heard of other negative reactions between cannabis and SSRIs.
 
Effexor and weed, serotonin syndrome? I dunno..I doubt that. My father smokes probably an 8th of nug a day, and was on Effexor for about a year. Now he's on Zoloft and he's the same as ever. So I dunno, I guess it COULD happen - just not to my old man, haha.
 
>>spooky language
You are talkin over my head man, sorry. :/>>

Terse paraphrase:
it's possible.

ebola
np: venetian snares
 
I had a friend who had loads effexor and didn't want them, he was prescribed them, anyway to cut a long story short we ate too many one night with alcohol and ended up near dying, the whole lining of my stomach was coming out my mouth, wasn't puking out anything, no food just rotten.Ah fuck that was one shite night and i feel asleep too, i was lucky.

Terrible shit drug.

Never knew it was bad with weed, fuck we used to smoke loads of hash and then eat a few of those. I remember whenever one of my friends ate 5 back to back after drinking a liter of wine, fuck he was sick too. Never seen someone as white in my life.
 
^ I don't even consider it a "drug" in the recreational term.. And just randomly popping SSRI's isn't really a bright idea.. I hope you and your friends have stopped this and are now aware of the effects of this crap.
 
hmmm... If weed is a reuptake inhibitor, does it have any interesting effects when taken in conjunction with ecstasy? Cuz if prozac can sort of turn off e, and prevent any negative effects, does weed do this in any small way? I know its got some neuroprotective properties with regards to head trauma.

Bilz? got anything 2 say?
 
WAIT, HOLD THE PHONE, JUST A SECOND.... ok Enough of that
But for real, I thought Weed increase seritonin production, insted of re-uptake ??? or do you mean that mixed with ssirs errr what ever its called, it re-uptakes insted of out-put......... Or am i just all mixed up, Blizor i need you to set me stright...... I know it re-uptakes Dopamine and that is what makes you jerk and shake some times on weed
 
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Blowmonkey said:
^ I don't even consider it a "drug" in the recreational term.. And just randomly popping SSRI's isn't really a bright idea.. I hope you and your friends have stopped this and are now aware of the effects of this crap.
Click to expand...

Neither do i.

Yes we have. I would never eat that shit again after what happened before on them.

And in combo with E is it a dangerous mixture?
 
Im pulling this out of my ass here, but I would say, nope, because effexor is still a ssri, like prozac, which negates the ecstasy buzz. If your synapse cant reuptake, then the revolving door type action of ecstasy on seratonin is negated, thanks to your mao's.
 
Well I've been smoking nugs almost daily, and taking Effexor XR for like a month already now until yesterday due to its side-effects. Blurred visions, made my insomina worse, I can't stand these side-effects it's been giving me. I dont see any signs that points to Serotonin Syndrome from mixing nugs and Effexor though. Went through Serotonin Syndrome from mixing DXM with Wellbutrin years ago. Yes it was a bad choice.

Not everyone experiences same side-effects from taking any chems/meds.
 
It might be a good idea for anyone suffering from depression to cut down on the herb anyways... I notice that if I smoke everyday, I begin to get depressed after about a little more than a week. Nothing serious, just not at my tip-top (though sometimes it can get bad). As soon as I cut back, my mood bounces back. Even if pot isn't causing these dips in mood, refraining from it for a few days now and again certainly leads to my mood's elevation
 
Well cannabinoids are definatly neuroprotective in regards to MDMA induced neurotoxicity, but why that does it is unknown... it's probably not CB1 receptor mediated, but it could be antioxidative of via reuptake inhibition... the experiment in question isn't the best, so it's hard to comment.

Compton-L337, lets just go through some things point by point
1) Cannabis increases the amount of released serotonin in the brain
2) Cannabis increases the amount of released dopamine in the brain
3) There are study which shows that delta9-THC inhibits the uptake of serotonin (at quite high levels).

When a chemical blocks the uptake of neurotransmitter, it means that there will be more of that neurotransmitter floating around.

It's likely, however, that the increased serotonin (and dopamine) is caused by THC, activating the CB1 receptor on GABA releasing neurons, and reducing the amount of GABA released. GABA is an inhibitory neurotransmitter, so if there is less of it, there is less inhibition of neurons which released serotonin and dopamine. Hence, more serotonin and dopamine.
 
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