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Possible ways to avoid problems on E

(zonk)

(zonk)

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Not sure if this the right forum, if not plz move 4me thanks...

Being that buying street extacy can be dangerous with the weird combos out there, I was wondering if there were ways to stay safe just incase you get extacy that was mixed with DXM or PMA or PMMA. From what I gather the most dangerous thing is overheating and hypertension. Could taking viagra or nitrates for vasodilation/lowering BP and taking ALOT of paracetamol(3g or so)to reduce body temp prevent the hyperthermia+hypertension?
 
^Why/How?

I also noticed that baclofen might be used to reduce body temp in high dose MDMA poisoning. baclofen at 100-200 mg was shown to be fairly effective(atleast in rats) and I guess that'd b better than taking 3g+ of acetaminophen. But I don't know how gabergic it is. It might kill the roll of the extacy so I dont know how usefull it'd be?
 
Actually that articals not on aspirin, it's called salicylate. Aspirin is a kind of a one of a kind drug, yes there are other fever reducers out there but not all aspirin like drugs are fever reducers. Ibuprofen is no where near as good at reducing fever than aspirin, although it is a much better analgesic. Ibuprofen and aspirin and probly salicylate are both COX inhibitors
 
rocknroll714 said:
Paracetamol is highly effective at depleting glutathione stores, the body's major endogenous antioxidant. MDMA causes its neurotoxicity (as well as hepatoxicity) through oxidative stress (which antioxidants inhibit/prevent). MDMA's already severely neurotoxic all by itself and combining it with high doses of paracetamol would be damn near one of the stupidest things you could possibly do.
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While I would agree that combining paracetamol with MDMA is not recommended at all (for the general and simple reason that one should never combine more drugs than absolutely necessary), I think that the reasoning is faulty:
Paracetamol depletes the glutathion-stores mainly in the liver, while MDMA's oxidative stress is harmful mainly in the brain. Due to the highly polar nature of the molecule, it won't cross the BBB and thus, the storages of liver and brain are separated.
Still, the combination poses an increased stress factor for the liver and this is never a good idea. In general, Rocknroll714 was absolutely right with his note of caution!

- Murphy
 
(zonk) said:
Actually that articals not on aspirin, it's called salicylate. Aspirin is a kind of a one of a kind drug, yes there are other fever reducers out there but not all aspirin like drugs are fever reducers. Ibuprofen is no where near as good at reducing fever than aspirin, although it is a much better analgesic. Ibuprofen and aspirin and probly salicylate are both COX inhibitors
Click to expand...

Aspirin is O-acetylsalycilic acid and is quickly hydrolysed in the body to salycilate.
 
rawk said:
A 5-HT2A/2C receptor antagonist like most atypical antipsychotics, mirtazapine, trazodone, cyproheptadine, and various other drugs would be your best bet.
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re: mirtazapine:

Would the binding affinity at 5ht2a/c be strong enough to temper overheating via excess intercellular 5ht? What about mirtazapine's downstream effect of increasing 5ht activity?

ebola
 
Thanks for the info! :)
However, I'm now wondering why mirtazapine doesn't temper MDMA's 'trippiness', nor does it block MDA's visuals...well, in my brain.

ebola
 
Mirtazapine has been found to be effective on combatting stimulant abuse, and does reduce the euphoria or cravings caused by classical amphetamines. SWIM noticed that it does not effect MDMA or other SRIs at all.
 
Anonyymi said:
Mirtazapine has been found to be effective on combatting stimulant abuse, and does reduce the euphoria or cravings caused by classical amphetamines. SWIM noticed that it does not effect MDMA or other SRIs at all.
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SWIM isnt a good source, been reading what drugs he has been doing lately, thus guy definatly fried he's brain.
 
echinaciea for the comedown,try to stay away from drinks that are dehydrating ,keep ur salt levels up so gatorade is a good buddie,the less alcohaul u drink,the less problems ul have,and the more cigeretts you smoke,the more ur heart is gonna beat above its regular heart beat,eat food if you can,you might just enjoy it just dont eat a steak or ul probably convice urself to go vegetarian before the nights over lol.
 
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