Possibility of increasing ethylone BBB access in response to lack of N-Methyl ?

[Sapphires]

I am not a chemist by any means but I've gathered that the N-Methyl is what pushes a substance through the blood brain barrier more easily. If this is the case, it would explain the reduced potency of ethylone (3,4-methylenedioxy-N-ethylcathinone) compared to methylone (3,4-methylenedioxy-N-methylcathinone) as they are ethylcathinone vs methylcathinone.

Short of changing the chemical structure, is it possible to theoretically use another chemical or supplement to increase the readiness of the cathinone to more easily pass through the blood brain barrier thus increasing the potency more similar to its methyl counterpart or would this prove to be far too dangerous in practice or simply impossible?

If this is in the wrong section, forgive me.

Also I apologize if I've completely butchered any basic chemical laws.

 

[ebola?]

This is the right forum for this type of discussion, but your inferences are not correct. In general, non-polar molecules pass the BBB more readily than polar compounds. This explains the most of the reduced potency of cathinones in contrast with their non-beta ketone substituted homologues. However, with monoamine releasers, n-methylated compounds tend to have greater affinity and efficacy at transporters than their n-ethylated counterparts.

ebola

 

[SNR]

This is the right forum for this type of discussion, but your inferences are not correct. In general, non-polar molecules pass the BBB more readily than polar compounds. This explains the most of the reduced potency of cathinones in contrast with their non-beta ketone substituted homologues. However, with monoamine releasers, n-methylated compounds tend to have greater affinity and efficacy at transporters than their n-ethylated counterparts.

ebola

Great information. This explains a lot to me about cathinones vs. amphetamines.