Positional Isomers of Amphetamine

[Slapdragonx]

They should be active because β-Methylphenethylamine is reported to be active in humans, due to the beta-methyl slowing metabolism by MOA. However it may be a MOAI, due to p-chloro-beta-methylphenethylamine being a potent MOA-B inhibiter (0.55Ki).

Kinemuchi H, Arai Y, Toyoshima Y, Tadano T, Kisara K. Studies on
5-fluoro-alpha-methyltryptamine and p-chloro-beta-methylphenethylamine:
determination of the MAO-A or MAO-B selective inhibition in vitro. Jpn J
Pharmacol. 1988 Feb;46(2):197-9. PubMed PMID: 3379831.