I've read some posts on this forum talking about using milk or olive oil to plug benzodiazepines and other non-water-soluble compounds.
I've always assumed that water solubility was more or less besides the point when it came to plugging, much as it is with swallowing pills. From my sketchy recollection of high school Bio class, I believe out GI track, from the stomach to the colon, has active transport pathways that it uses to extract non-water-soluble nutrients from food, and they clearly work on pills as well.
So what, if anything, would one be achieving by dissolving a non-water-soluble compound in milk-fat or vegetable oil, if these lipids are going to require the same active transporting to get from the GI system into the blood stream as the non-water-soluble drug does in the first place?
I've always assumed that water solubility was more or less besides the point when it came to plugging, much as it is with swallowing pills. From my sketchy recollection of high school Bio class, I believe out GI track, from the stomach to the colon, has active transport pathways that it uses to extract non-water-soluble nutrients from food, and they clearly work on pills as well.
So what, if anything, would one be achieving by dissolving a non-water-soluble compound in milk-fat or vegetable oil, if these lipids are going to require the same active transporting to get from the GI system into the blood stream as the non-water-soluble drug does in the first place?
