Piribedil - A possible antianhedonian and cognitive enhancer.

[/navarone/]

Greetings.

I'm recently evaluating a possible therapeutic regimen of Piribedil (along with Nicergoline, racetams, theanine, minimal doses of of ketamine (a la Jamshid way) along with a strict healthy diet) in order to treat a persisting sort of anhedonia/depression and possibly trying to recover from some pre-existing brain damage frm various drug abuse.

Aparte from all the other substances I listed above I was looking for som in depth information onthe therapeutic uses of pirimedil on a long trm regimen,I've herad rumors that treatment with this drug necessites periodic increase in doses probably due to receptor downregulation.

Also I was curious to know if there could be some severe interactions between the drugs (in therapeutic doses) on the long run.

Anyone here who had some experience with pipibedil or who could shed some light on the routine I am planning to start?

Any info would be greatly apreciated!

Peace!

 

[PsychedelicPeptide]

I think piracetam (plus a choline precursor like DMAE or alpha-GPC of course) along with fish oil and exercise will help you plenty at recovering from drug-induced brain damage.

Regarding piridebil, downregulation of dopamine receptors doesn't sound like something I would want over the long-term so I would suggest taking the stuff less than daily, preferably with breaks. But I don't know anything about the drug or its effects.

 

[/navarone/]

Thanks for your reply.

You've probably consulted the Wiki article regarding piribedil. What drove my interest towards it is its therapeutic use for treating severe anhedonia along with its memory and congitive enhancing potentials.
Also I'm pretty certain about including Nicergoline considering a brief past experience and it's ability to enhance oxygen metabolism in the brain through vasodilatation, treatment of migranes, and ability to increase nerve growth factor. Found it much more effective than hydergine IMO.

Even if it is not listed on wiki on the pharm 'information booklet' it is reccomended to double the dose every 2-3 days up to 4 pills a day after 10 days of treatment (at least for the 20mg not XR, there is also a 50mg XR product), that though could be the reccomended therapy for treating severe parkinson syndrome.

Anyway that increasing dose theraphy made me think that it could possibly be due to D2 and D3 receptors dowregulation or maybe it's just a medical advice to let your body gradually get accustomed to the pharm.
Could someone clarify this?

PS. I'm already taking lecithin which is a great choline supplement and is also cheap and can be found OTC, plus lots of vitamins, Omega 3 supplements and 2 cups of green tea daily.

Cheers

 

[/navarone/]

Basically though my main question is:

Could a moderate therapeutic regimen of this medication cause D2 / D3 receptor downregulation?

 

[kken]

ive tried it to repair mdpv induced up regulation, it was a huge disappointment and i could not feel the effects.. possibly too low dosage as it was Rx'd. it did reverse some of the memory impairments from my benzo regimen!

 

[/navarone/]

Cool, thanks for your info.
I was actually highly doubtfull that anyone here tried it since it's normally prescribed for parkinson's (especially here in italy) but as soon as i came across it on wiki i managed to get illegal prescription for just a 30 pill 20mg box. Haven't done any since then, though i do remember that it it tune up my depression induced hyposexuality and had some minimal effects on my anhedonia.
I guess I should have continued with it..but for some reason I didn't.

BTW did you get it prescribed by a doc? For how long?

 

[kken]

i was on it for 3 months with no noticeable effects related to dopamine , the memory enchantment was permanent which was cool

 

[/navarone/]

I'm not interested in this drug a recreational substance so dopaminergic stimulation do not interest me that much. However did it improve you're anhedonia (lack of percieving pleasure)? Does it have any value as an antidepressant?

What doses where you prescribed or attended to?

 

[negrogesic]

My question would be; how do measure improvements in cognition, especially "subjectively", without testing or imaging etc (and you are not going to see much; even using advanced-expensive imaging).

The bulk of the "life-extension science" is simple people afraid of death; personally I liked what Huxley sarcastically proposed in Brave New World, automatic death at 65 in good physical condition. I do not want to live to be 140 years old.......but can we make this possible? Currently there is certainly quite a bit of people and money behind this sort of research, but I don't see a "major" breakthrough in this century (I could be wrong; i'm often wrong)....

I don't know if you guys recall, but there was some older physician who came onto this board a while back (who I sort of revealed to be a nut), and this individual was taking this long list of compounds to extend his(her?) life. He even said he washed his entire body with Hibiclens every day (chlorhexidine, a rather expensive anti-microbial to use on your entire body every day)........Generally this and Betadine (povidone-l) are used in perioperative settings...........To bathe in it is a bit much, and likely not healthful in the long-run........

 

[/navarone/]

What are you talking about? I think you completely missed the main reason of this thread.

My question was completely different from what you understood.
I have no intention of living forever nor hyperclensing my body but if you read more carefully, my question was about the efficacy and possible adverse effects of piribedil along with other known nootropic/celebral vasodilators to treat anhedonia and different kinds of cognitive and memory impairment, (mostly due to past drug abuse, in my case).

How do uoi measure improvement in cognition?
Well try drinking hard liquor along with heavy benzos for about a week and then return to complete sobriety for a month, then tell me how your cognition percievably changed.

Who wants to live 150 years? I just wanna live happily and get rid of some disturbing emotional cognitive impairments, especially considering my young age.

Your post was pretty out of the blue, other than out of topic.

 

[/navarone/]

BTW, after taking a look at the molecular structure, could it be that it has any kind of AMPA affinity (considering some similiarities with the experiemntal CX-xxx compounds)?
Could that account for it's cognitive and mnemonic enhancing ability or is it merely a result of selective dopamineric agonism?