Piperidione - unscheduled barb derivative?

[wungchow]

I was flipping through my Merck Index and found this listed as a sedative and antitussive. It's very similar in structure to methprylon, used to be sold under the name Sedulon.

 

[negrogesic]

It is also similar to glutethimide; I wonder what the potency is like...

 

[wungchow]

I found a google books result here that lists some journal articles dealing with this compound. Unfortunately I have no online journal subscriptions

 

[wungchow]

Another derivative of piperidine must be mentioned, although it is ofsimpler constitution and does not belong to the pethidine series : 3,3-diethyl-2,4-dioxopiperidine, also called NU-1510, or " sedulon ".16 Itseems to give good or fair sedation ; 0.25 g. was administered three timesdaily for three to five months. One patient, after one month, " was appre-hensive about continuing the drug" ; it was stopped several days later.This drug, therefore, seems at least sufficiently suspect of habit-formingqualities.

source

 

[wungchow]

SEDULON

Manufacturer Hoffmann-La Roche Limited, Montreal.

Description A new, non-narcotic cough remedy which can often be used in place of
codeine. Chemically Sedulon is 3,3-diethyl-2,4-dioxo-piperidine in an extract of thyme base.

Indications For the symptomatic relief of coughs in colds, pharyngitis, laryngitis,
trachitis, bronchitis, influenza, pneumonia, and other conditions stimulating the cough reflex.
It is well tolerated by infants, children, and adults alike.

source

 

[Hammilton]

Would be interesting to see other derivatives; would the seconal analogue have the same recreational potential, perhaps?