Pink oxy 10 mg do not work??

[janec]

I was prescribed oxy 10 mg. The pharmacy is now giving me the pink oxy, and it does nothing. Anyone have a similar experience?

 

[Deleted member 580309]

Certain people are very sensitive to their brands I know that for a fact, only one certain brands adderal worked for my friend while the rest did nothing. Did you rule out any outside factors like recently had a really big meal

 

[Oxyleo25]

what brand oxy is it?

 

[Keif' Richards]

Unfortunately, we can´t field threads like this because there is no way for us to effectively answer this question. The best you could ever arrive at would be more questions. People´s experiences vary and will not necessarily apply to your specific biology. I would recommend finding a way to get a different brand if possible. Don´t mess with them if the y do not work.

 

[PenguinWithNapalm]

Unfortunately, we can´t field threads like this because there is no way for us to effectively answer this question. The best you could ever arrive at would be more questions. People´s experiences vary and will not necessarily apply to your specific biology. I would recommend finding a way to get a different brand if possible. Don´t mess with them if the y do not work.

Yeah I hear this so much but I’ve never personally noticed a difference. there are so many people that say it though that it makes me so curious.

 

[Keif' Richards]

@PenguinWithNapalm something a lot of people are not aware of, is that certain food-colorings produce what are essentially allergic/unwanted reactions in people who are sensitive to them. It could be the food-coloring in OP´s pills have led to, not necessarily the Oxycodone not working, but perhaps some of the non-active contents of the tablets making the expected relief not as potent. There is a lot to unpack with this topic and we don´t get a ton of honest information from the pharmaceutical companies. I wasn´t a believer until I started reading about some of this shit.

 

[PenguinWithNapalm]

@PenguinWithNapalm something a lot of people are not aware of, is that certain food-colorings produce what are essentially allergic/unwanted reactions in people who are sensitive to them. It could be the food-coloring in OP´s pills have led to, not necessarily the Oxycodone not working, but perhaps some of the non-active contents of the tablets making the expected relief not as potent. There is a lot to unpack with this topic and we don´t get a ton of honest information from the pharmaceutical companies. I wasn´t a believer until I started reading about some of this shit.

Wow, and that would have never even crossed my mind. A lot to unpack indeed.

 

[Them Witches]

I keep bringing this up but it does not seem to get much play. Generic medications are not created equal to brand name versions and some manufactures of generics are not as strong as others.

The FDA allows up to 20% variance in active ingredient between generic vs brand name. Some generics are as strong as the brand name. Common google searches will not explain this 20% difference.

Generics have different binders compared to the brand name vise versa.

Mallinckrodt generic Oxycodone HCl is the best available. However, the Mallinckrodt brand name "Roxicodone" is a little bit better and has a better delivery. Over the past 15 years I have Rx'd every brand generic and brand name and Mallinckrodt is the best generic available. KV-Tech generic comes in 2nd place.

Sandoz makes their generic fentanyl patches as strong as their brand name = 100mcg equals 16.4mg of active ingredient in both versions. However, Watson generic 100mcg only has 10mg of active ingredient. That is a big difference.

Rhodes generic Oxycodone HCl are so weak I cannot even feel them. They are oversized and have a poor delivery. Mallinckrodt are tiny and have a rapid effect.

 

[Them Witches]

The "pink 10mg" are made by KV-Tech which are not as good as the Mallinckrodt generic. Mallinckrodt sells the active ingredient compound to almost every other manufacture and can afford to have more active ingredient in the generic version. Everyone in pain management says the same thing as I do about this. Many pharmacies will only order Mallinckrodt because if they do not people will not fill there. This goes for every other pain killer they make, the Methadone 10mg are better than any other generic on the market. Same with Diluadid and same with Exalgo.

The perception that Mallinckrodt generic oxycodone is among the best available largely stems from anecdotal reports and patient reviews, which suggest it provides more consistent pain relief compared to other generic manufacturers. There is no official, universal rating system by regulatory bodies that ranks one generic as inherently "better" than another, but individual patient experiences vary widely, often due to inactive ingredients.

Key Factors in Patient Preference

• Perceived Effectiveness: Numerous patient reviews on medical forums like Drugs.com and WebMD consistently rate the Mallinckrodt brand (often identified by the "M" on the pill) as one of the most effective generics for pain management. Patients often report that other brands like Rhodes, Amneal, or Camber are less effective, have a "placebo effect," or cause more side effects like nausea and headaches.
• Inactive Ingredients (Fillers): While generic drugs must contain the same active ingredient (oxycodone HCl) and meet the same potency and bioavailability standards as the brand-name version, they can use different inactive ingredients (binders, fillers, dyes). These different fillers may affect how quickly the medication is absorbed, how a patient's body metabolizes it, or may cause allergic reactions or stomach upset in sensitive individuals. For some patients, Mallinckrodt's specific inactive ingredients work better with their system.
• Consistency: Some patients report that the Mallinckrodt brand offers more consistent results across different batches compared to other manufacturers, though quality across all brands has been a general concern among chronic pain patients.
• Reputation for High-Quality APIs: Mallinckrodt is a major, vertically integrated manufacturer of active pharmaceutical ingredients (APIs), including controlled substances like oxycodone. This domestic control over both the API and the finished product is sometimes perceived by patients as contributing to a higher quality, more consistent product.

Regulatory and Other Considerations

• FDA Equivalence: The U.S. Food and Drug Administration (FDA) requires that all generic medications demonstrate bioequivalence to their brand-name counterparts, meaning they should work the same way in the body. Pharmacists are required to inform patients that generics are therapeutically equivalent.
• Opioid Crisis Context: It is important to note that Mallinckrodt, like other opioid manufacturers, has faced significant legal scrutiny and lawsuits regarding its role in the opioid crisis, including accusations of failing to monitor suspicious orders of oxycodone. These issues relate to distribution practices rather than the chemical efficacy of individual pills for legitimate pain patients.

In summary, the preference for Mallinckrodt appears to be based on personal experiences and perceived clinical effectiveness, which some patients attribute to the specific formulation and fillers used by the company.