picamilon safety profile

[asecin]

besides crappy article on wikipedia i cannot find any good reliable literature behind addiction and/or withdrawal problems related to picamilon. i would think since it is direct GABA agonist, it might be just as bad as benzos when it comes to withdrawal, anyone actually has an experience to report ?

 

[TriputoryHeadicine]

3 weeks of daily usuage left me with no WD side effects. Going to push it a few weeks this tim, will report back : D

 

[Solipsis]

My guess would be that it is rather like phenibut in this respect, which will indeed give withdrawals if you don't cycle your use but the danger is nowhere near that of benzo's. I have been dependent on benzo's and it is horrible and very chronic. I have also used phenibut in a little too long stretches on occasion and while I did not feel pleasant for about a day and a half, it was doable and transient. I have only used picamilon incidentally.

Picamilon - as long as it does not dissociate into GABA and niacin, which I'm not sure of how quickly that would happen in the brain - would be considered a GABA analogue like phenibut. AFAIK it does not interact with benzo receptors?

As long as we aren't sure I would be careful to cycle my use with picamilon though, probably not scary enough to abstain completely but it is never wise to chronically elevate levels of such neurochems.

(By the way, come to think of it, picamilon could be a pretty sophisticated way to put the brakes on the tail end of an LSD trip, if so inclined. Both the GABAergic action and the niacin - purportedly - negating LSD effects would make sense theoretically)

 

[asecin]

so solipsis would you say picamilon is not a good idea to substitute for alcohol ? its like changing one addiction to another, no ?

 

[asecin]

here is my scientifically well formed review of that supplement; that shit is absolute crap

 

[ebola?]

Well, it is strongly suspected that picamilon hydrolyzes to GABA and niacin once having crossed the BBB, so depending on how rapidly this process occurs, we should expect it to be a relevantly potent direct and nonselective GABA agonist. In this way, it is similar to muscimol, though muscimol is selective for GABA-A (and phenibut and baclofen selective for GABA-B, all acting as direct agonists rather than allosteric modulators). As a rough cut, we might expect picamilon to be about as addictive as phenibut, but this is a really rough cut, as the neural circuits involving activation of GABA-B are pretty distinct from those involving activation of GABA-A (and no one I've heard of has taken muscimol habitually to offer us empirical data ).

So no, this will not be a good maintenance med in the long term, but it will be better than ethanol (one of the shittiest candidates for long-term maintenance around ).

ebola

 

[cpuller]

Isnt it that picamilon cant be dosed as high as phenibut because of the high amount of niacin you would then ingest?
That would be something like 150mg max for picamilon

 

[Epsilon Alpha]

^this, there is significant risk of taking waaaay too much niacin from some of the doses people ingest from this stuff.
If you are withdrawing from GABAgenic drugs please consult a physician to discuss clinically proven tapering methods. The stuff I've read on that from imminst really makes me look at that stuff skeptically.

 

[Limpet_Chicken]

Oddly, muscimol doesn't SEEM, on the face of it, to be very prone to causing physical dependency or withdrawals.

I've used small quantities daily or very frequently during cold weather, as a tonic, pick-me-up, adaptogen type med (although AFAIK it doesn't target the HPA-axis in any manner like true adaptogens do of course). I find it great for getting through shitty, cold, miserable winters. Never had any withdrawals ceasing use (a few grams per dose, as Amanita muscaria tea)