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Phenazepam and PEG 4000

negrogesic

negrogesic

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Jul 21, 2002
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I was curious if a mixture of polyethylene glycol 4000 and 99% ethanol (at at 1:4 ratio) would be sufficient in dissolving phenazepam....

My understanding of the determining factors when assessing solubility is limited...

I would use propylene glycol, but what i have right now is PEG 4000 and absolute ethanol....

Any ideas?
 
Well I think i figured it out. A small amount PEG 4000 in absolute ethanol 99.5% completely dissolved phenazepam. I doubt it would be safe for injection even if micron filtered, but it works orally....

And issues with prolonged PEG 4000 exposure?
 
Phenazepam completely dissolves in absolute ethanol anyway, without the addition of PEG.
What i'd be more interested in is dissolving phenazepam in PEG and then attempting to solubilise it in water with the addition of a surfactant, perhaps one of the Tweens.
 
MattPsy said:
Phenazepam completely dissolves in absolute ethanol anyway, without the addition of PEG.
What i'd be more interested in is dissolving phenazepam in PEG and then attempting to solubilise it in water with the addition of a surfactant, perhaps one of the Tweens.
Click to expand...

What are Tweens?

Also if one was to dissolve phenazepam in absolute ethanol 99.5% (is 99.9% ok?) is it ok to consume basically pure ethanol, even if it is a few mililitres at a time?

Hey negrogesic stay safe man! Phenazepam is very cheap and easily available compared to diazepam, which I remember you posting's about your battle coming off of a large dose of it! :\
 
Yes, good looking out, but my thinking from that stage has changed. I am no longer in a self-destruct mode. I am being very careful, and am not on a mission to get high. I am simply looking for an alternative to xanax to be used in low doses as an anxiolytic. The problem is, phenazepam seems to cause the worst amnesia of any benzo ive encountered.

Could an ethanolic suspension of phenazepam be injectable if passed through a micron filter (by IM perhaps)? Or it would the pH need to be adjusted, and preservatives like BeOH added?
 
I wouldn't want to inject any concentration of ethanol. Isn't there a soluble salt of phenazepam? It also seems to vaporize well.
 
I would like to know more about this as well.

Does anyone know if there is a list of known substances that can dissolve phenazepam (besides ethanol and PEG of course)?
 
So far, propylene glycol, absolute ethanol 99.5%, and PEG4000 increases the solubility, it dissolves immediately in DMSO and it dissolves in chloroform. I do not believe that it is soluble in ether. Of course its soluble in toxic solvents like ethylene glycol, but don't do this of course.......
 
It is soluble in 40% alcohol/ethanol or at least 37.5% alcohol/ethanol?


The reason I ask is cause I only have a tiny amount of whiskey left. If it work's I'll heat the spoon for extra safety to sterilise it though.
 
Is Phenaz soluble in PEG on its own?

Since it is active at sub-mg doses, sounds like it makes a perfect candidate for being used as nasal spray... alot of "nasal lubricants" have PEG as their main ingredient...
 
After combining phenazepam and propylene glycol (can anyone post some basic info on how that is most efficiently done?), and after you liquid-measure out a single dose, is there a way to remove the propylene glycol?
 
Captain.Heroin said:
After combining phenazepam and propylene glycol (can anyone post some basic info on how that is most efficiently done?), and after you liquid-measure out a single dose, is there a way to remove the propylene glycol?
Click to expand...

I cannot answer the second part of the question, but I can tell you how I successfully completed the first.

Measure 100 mg phenazepam with an accurately calibrated scale.

Measure 100 ml USP/food grade propylene glycol (easily, cheaply, and legally available all over the Net from non-sketchy sources) in a graduated cylinder or similar.

Combine in clean plastic or glass container (I used a small plastic empty travel bottle from Walgreens), agitate for a bit, and dose with calibrated dropper or baby syringe. I found the powder to dissolve easily and quickly with this method and agitate the bottle every time it is dosed even though this is probably not necessary, as it appeared to have dissolved completely when I squirted some on a mirror.

I do not know of any way to remove the propylene glycol, but it is odorless, tasteless, and if you squirted 1 ml in juice you wouldn't notice a thing. It is not the most convenient way to dose when you're out and about, but you probably wouldn't want to take much of this stuff in public. You can always prepare a water or juice bottle before you leave (not driving of course ;)).

negrogesic - how much are you taking? I have noticed the same disinhibition and amnesia from this drug, which is why I take scripted benzos now for the most part.

The propylene glycol method worked out very well for me and my fellow lab rat. To be on the ultra safe side, mark your bottle clearly and add food coloring the way many smart people do with GHB/GBL... and be very careful mixing phenazepam with alcohol.

**Edit - negrogesic, it appears you're asking about shooting it (mention of micron filter) which I originally overlooked. I will have to defer to someone else on the safety of shooting the way you describe, or with the propylene glycol method, as I have not tried to IV phenazepam and personally would not recommend it. I hope you get the answer you need, and stay safe. **
 
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negrogesic said:
Well I think i figured it out. A small amount PEG 4000 in absolute ethanol 99.5% completely dissolved phenazepam. I doubt it would be safe for injection even if micron filtered, but it works orally....

And issues with prolonged PEG 4000 exposure?
Click to expand...

I dunno about PEG and ethanol but if you have pure propylene glycol and phenazepam you should not even need a filter at all. I know lorazepam and diazepam ampoules for injection are prepared in a solution with propylene glycol.
 
99.8% pure PG can at least take in 2mg/1ml with out the help of heat
 
Just got my 200mg phenaz, cheap mg scale, ml syringe, and 91% iso alc.

Will my phenaz be able to dissolve in 91% iso alc with heat and agitiate?

As stated above, why add food coloring to the solution?
 
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I'm not sure why you'd inject this stuff.

Hits fast sublingually, and you don't need a rig or any of this rigamarole (pardon the alliteration), just dissolve it in everclear (i've gotten ~10mg/1ml (1mg per 5 drops)), drop it under your tongue (or blotterize it for using on the go).

Using PEG as solvent (you can't really get rid of it like ethanol) to dissolve relatively low concentrations and then injecting it seems to be like building a set of stairs to get to the top of a ladder.

Blazelate, you'd add food coloring if you were storing the solution and live around morons who'd be like "Wuts this bottle here? *sniffsniff* Roommate hide vodka on me! Ha! *gulp*"
 
C.H couldn't you let that dose dissolve? Does PG quickly dissolve gelcaps? If not, you could fill them and probably let it dissolve in that and have easy made caps.
 
Forget PEG and PG, I simply use A.C.S grade absolute ethanol (anhydrous, 99.9%). I think its even kosher. I don't buy it online though, I take if from the lab at school. Avoid the the technical grade shit.

I use a 4mg/ml concentration....
 
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