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Pharmacology of L-Glutamine as alcoholism treatment

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fungus44

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Pharmacology of L-Glutamine as alcoholism treatment?

I was hoping that someone involved in the ADD forum could provide information or ideas about how l-glutamine works to block cravings for alcohol or how l-glutamine works in relation to the glutamate receptors.

Thanks.
 
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There may be some aspect of a "placebo effect" involved, nevertheless, there are a number of articles and studies that you should be able to acess with a search.

My basic understanding is that people that are addicted to alcohol tend to have very poor dietary habits. The bad diet combined with the fact that alch. throws your insulin and blood sugar levels out of whack are said to perpetuate the craving for the alcohol. Glutamine and other amino acids help the body to restore proper nutrition/insulin levels and are said to lessen the craving for alch.
 
^ Lol. Hardly a scientific tome.
"Rogers, L. L., R. B. Pelton, and R. Williams. "Voluntary Alcohol Consumption by Rats Following Administration of Glutamine." Journal of Biological Chemistry 214.2 (1955): 503–506."

Welbourne, T. "Increased Plasma Bicarbonate and Growth Hormone After an Oral Glutamine Load." American Journal of Clinical Nutrition 61 (1995): 1058-1061. <--- Where the glutamine was given in coke, with no vehical control. *gasp* sugary drinks cause an increase in growth hormone secretion, stop the press.

The "mood" reference is quite interesting, but seeing as it is pulished in such an, esoteric, journal, which I don't have access to, I can't really comment.
 
^^^
There is no purpose being served by you being such a negative prick on the matter.

The person merely requested information and I simply led him in the direction that may help him/her.

By simply searching the query; "l-glutamine, alcohol", you will find a plethora of related materials, some, not involving rats.

Lighten up.
 
Dude, I just can't find any supporting evidence. I don't believe you have shown any, and I don't believe there is any, apart from anecdotal evidence. Show me a clinical trial, or even rat data, and I'll believe.
 
I had meant to thank PM for the references, but have been a lazy butt. I hadn't thought to look in the Steroid Discussion.

Is there any sense of why there haven't been more controlled studies? The unpatentability of l-glutamine?
 
I would imagine because there is no reason to think that it would do any good. It doesn't strike one as obviously logical, or even distantly related.
 
thanks for the info pottedmeat! i, too, i have read about many positive effects inolving l-glutamine in alcohol withdrawal. I also agree that blizor has no justification for being so pessimistic on the matter. A SIMPLE google search would reveal MULTIPLE studies on the matter (in fact, within the first 3 results).
 
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