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Pharmacological Dangers Associated with Combining Ethylphenidate with Dimethocaine?

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benze

Greenlighter
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Feb 18, 2007
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Both drugs have weaknesses. Ethylphenidate feels like asshole in your nose. Dimethocaine has a poor DAT inhibition:anesthesia profile, thus rendering its toxicity higher than necessary.

The combination would result in a need for less dimethocaine to inhibit the transporter, and hopefully still provide enough numbing to not make you hate yourself everytime you sniff a line.

Anyone have any ideas why this might not be the greatest idea. Besides of course "too many unknowns".
 
Because dimethocaine is an anesthetic that tries too hard to be a stimulant and fails at both.

Realistically, adding any local anesthetic will result in increased risk for adverse cardiovascular events. Especially when you mix it with stimulants that make it easy to redose, and redose and redose.

If you are adamant about making fake cocaine then do what everyone else does and add 5-10% w/w lidocaine or benzocaine. Avoid dimethocaine, costs too much. Or just buy/extract your own damn cocaine.
 
The friend I have who is interested in this can get dimethocaine for the same price as other anesthetics. It is not from a research chemical vendor, but rather from a vendor of all manner of anesthetics and are all roughly the same price. If you consider that is is the same price as lidocaine/benzocaine, does anyone see a reason that this is a really bad idea?

(Please don't PM asking for the source.)

Also, the friend of interest cannot afford cocaine, but could make a gram of 50 dimetho:50 ethylphen substitute for a few dollars. And he does not particularly enjoy the effects of cocaine, but years of being an addict (a long time ago) have left his nose occasionally thirsty for something white and numby, with a bit of a kick.
 
Given that DMC is widely reputed to be basically non-recreational but yet still shares the cardiovascular side effects of stimulant anesthetics it is safest to use one eith an excusively anesthetic effects profile to avoid the chances that heart rate is potentiated out of control.
 
Does the cardiotoxicity not arise directly from the anesthetic action itself? It was my understanding that the blockade of sodium channels that produces the anesthetic action was also the mechanism through which myocardial depression occurs. If I am mistaken, please, enlighten me.

If that is the case, less anesthetic would be required, because the anesthetic being used is also a stimulant, and therefore, the overall line size would be smaller.
 
Also, many people who have gotten dimethocaine that wasn't caffeine and lidocaine seemed to enjoy it very much. I don't think it can be called "non-recreational" when many enjoy using it recreationally ;)
 
DMC is cardiotoxic by two modes:
1. dopamine/norepinephrine reuptake inhibition constricts blood vessels, raises blood pressure, raises heart rate (decreased cardiac blood flow)
2. sodium blockade interferes with heart muscle conductivity (decreased cardiac conductivity, decreased cardiac output)

Basically what I am saying is in the interest of harm reduction you should minimize the amount of anesthetic you are ingesting. It may even be best to "pre-load" and numb your nose with a pure anesthetic solution (10-20mg lidocaine or something) and leave the anesthetic totally off the table for the remainder of the experience.

If ethylphenidate has a stimulant action that you find agreeable, it should be the primary drug in your blend. DMC is a much weaker stimulant than ethylphenidate anyway.
 
lol fair enough.

But no, my buddy doesn't find ethylphenidate agreeable. Does anyone REALLY find ANY stimulant besides the delightful methylenedioxy substituted ones agreeable?

... I know some people think they do.

But I don't think its actually possible. They feel like crap.

...But for some reason, you get drawn back for more :S haha!
 
But no, my buddy doesn't find ethylphenidate agreeable. Does anyone REALLY find ANY stimulant besides the delightful methylenedioxy substituted ones agreeable?

... I know some people think they do.

But I don't think its actually possible. They feel like crap.
Click to expand...

I know lots of people who enjoy "plain" stimulants like methyl/ethylphenidate, it's just that more often than not they aren't using them to produce euphoria and instead using them as a tool to enhance energy/productivity/focus.
 
benze said:
lol fair enough.

But no, my buddy doesn't find ethylphenidate agreeable. Does anyone REALLY find ANY stimulant besides the delightful methylenedioxy substituted ones agreeable?

... I know some people think they do.

But I don't think its actually possible. They feel like crap.

...But for some reason, you get drawn back for more :S haha!
Click to expand...

Oh ok. Someone should probably let the tweakers know that they're not actually experiencing extreme manic euphoria. Might save them some money... ;)
 
.... lol. My friend has tried probably 20 different stimulants including crack, meth, amp, cocaine HCl, etc. and while they... demand attention and continued use... I don't think anyone is actually like "This, right here, is fucking perfect. I don't need anything else. I'm happy and having a great time!".

Maybe its just my personal chemistry. But I can't see how someone could enjoy the effects without being self-deluded.
 
Sekio, I don't think your logic follows. If the user is going to add an anaesthetic to make the drug more palatable, he might as well be adding one that contributes to the psychoactivity. Due to sodium blockade they're all going to be cardiotoxic, but the secondary heart issues (those not caused by direct effects on the heart but by increased heart rate and stress, for example) are going to be present one way or the other.

I didn't use high doses of dmc, and it was pure, while all of the analysis of commercially available samples I've seen have contained caffeine and other drugs, but I didn't find it to be markedly harder on the body than any other stimulants.

But until it's been tested and ruled out as better, I want to steer everyone away from dimethocaine. The para-desamino analogue, desamethocaine, would seemingly be a much, much better drug. To increase stimulant potency 3,4-dichloro should be tried. It's generally the most potent substitution for DAT inhibitors, para-methyl might be worthwhile as well. I originally played around with dmc not because I thought it was going to be a great drug, but because I wanted to know if there was promise there- and there is- but dimethocaine itself is not a drug I would have ever suggested would make a good research chemical. It's analogues on the other hand... Kidding, I don't want to see anything becoming a new RC. We have too many shitty drugs already.
 
Chances are extremely high that you do not have dimethocaine but rather some other compound (or a cocktail thereof) being passed off there as. So you should not combine an unknown mixture of compounds with another stimulant.

I don't think anyone is actually like "This, right here, is fucking perfect. I don't need anything else. I'm happy and having a great time!".
Click to expand...

er...isn't this the very goal of peak effects from stimulants? There's a reason that everyone thinks that amphetamine is an outright panacea at T+2 hrs. of their first time. :P

ebola
 
I felt that way from methylphenidate my first time. My first time with adderall I lost my hearing....
 
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