Nagelfar
Bluelight Crew
- Joined
- Nov 23, 2007
- Messages
- 2,527
Pharmacokinetics of "aqueous solvation" not related to hydrophobicity/lipophilicity?
input pg. 25, its interesting to note a difference in "aqueous solvation" mentioned in a way that seems unrelated to lipophilicity (logP etc.) or am I misunderstanding? I always wondered why, for instance, cocaine HCl "dissolves" in a flash in water, but is considered a highly lipophilic substance. Does anybody know of any resources that mention how well lipophilic substances are "solvated" or not based upon other pharmacokinetic/dynamic factors than straight over-all hydrophilicity, etc?
input pg. 25, its interesting to note a difference in "aqueous solvation" mentioned in a way that seems unrelated to lipophilicity (logP etc.) or am I misunderstanding? I always wondered why, for instance, cocaine HCl "dissolves" in a flash in water, but is considered a highly lipophilic substance. Does anybody know of any resources that mention how well lipophilic substances are "solvated" or not based upon other pharmacokinetic/dynamic factors than straight over-all hydrophilicity, etc?