PET scans on psilocybin

[any major dude]

Read this interesting post today regarding PET scans of people while on psychedelics. Anyone have access to the article? Seems like there could be some pretty interesting stuff there, both in the scans themselves and the methodology.

 

[JamtasticX]

Unfortunately I don't have access, but it's good to see more science with psychedelics instead of simply calling it vodoo science or something similar.

 

[ebola?]

I have access. I also have possession of the article now. PM me with some method to send it to you / post it for all to see.

 

[any major dude]

thanks a bunch for the email man!

 

[/navarone/]

I wonder ...why da heck haven't they ever synthetized a 4-Meo-DMT analogue of Psilocybin?

IMO..it would be much more pontent and long acting!

 

[any major dude]

you really don't see many 4-MeO's out there. For some reason i think its a whole lot easier to get the MeO on the 5. I have a vague memory of reading something about that in TiHKAL, but can't be sure at the moment.

I'd be interested to see some bioassays of 4-MeO-xxT though

 

[dread]

http://www.erowid.org/library/books_online/tihkal/tihkal39.shtml

4-meo-mipt is introduced in tihkal, it seems to be an active compound with a dosage of 20-30 mg which makes it about 20% potency of the 5-meo counterpart.

 

[hugo24]

And it was on the RC scene for a short time but it proved to be inconsistent and mild.

 

[any major dude]

yep, Shulgin does mention some difficulty in making this, which i suppose is why you rarely, if ever see 4-MeO's available.

I'm curious as to whether many 4-MeO's will be in the 2nd half of the Shulgin Index

 

[MurphyClox]

^I would think that the absence of 4-MeO-indoles is not due to presumable difficult synthetic accessibility but rather lower activity of these compounds. The oxygen in position 4 should be unsubstituted for viable activty.

- Murphy

 

[AcidTrip25]

awesome i want to read that whole article but i cant send messages until i hit bluelighter status ugh!

 

[MurphyClox]

Nicolas Langlitz
"The persistence of the subjective in neuropsychopharmacology: observations of contemporary hallucinogen research."
History of the Human Sciences 2010, 23(1), pp.37-57
DOI: 10.1177/0952695109352413

Abstract
The elimination of subjectivity through brain research and the replacement of so-called ‘folk psychology’ by a neuroscientifically enlightened worldview and self-conception has been both hoped for and feared. But this cultural revolution is still pending. Based on nine months of fieldwork on the revival of hallucinogen research since the ‘Decade of the Brain,’ this paper examines how subjective experience appears as epistemic object and practical problem in a psychopharmacological laboratory. In the quest for neural correlates of (drug-induced altered states of) consciousness, introspective accounts of test subjects play a crucial role in neuroimaging studies. Firsthand knowledge of the drugs’ flamboyant effects provides researchers with a personal knowledge not communicated in scientific publications, but key to the conduct of their experiments. In many cases, the ‘psychedelic experience’ draws scientists into the field and continues to inspire their self-image and way of life. By exploring these domains the paper points to a persistence of the subjective in contemporary neuropsychopharmacology.

<DOWNLOAD>


Peace! - Murphy

 

[naginnudej]

Thanks murph