Yes LSD and ketamine are like a catalysts added to a catalyst. I've heard from multiple individuals that they think it can be really crazy up to the point of 'not being funny any more'. Reality desintegration and that sort of thing.
The dose of each of the three, when you are to combine them, is of course essential. The dose of LSD is a primary factor if you ask me, but the dose of ketamine determines the level of dissociation (which may be obvious). A high dose of both can have unexpected results, highly altered and sometimes mystical states. A high dose of ketamine and low dose of acid may produce a more-than-interesting K-hole, a high dose of acid and continuous bumps of ketamine is quite doable and tends to give me a feeling of glory in a theological sense. I guess the holiness that DPT can produce very much reminds me of it. A splendid adjunct in any case.
Adding MDMA can if you ask me, actually ground you if the dose it not very high. Since it is a stimulant and has a very strong push on your mood I think it can give you a better sense of direction, reducing fear as well. But as the dose goes exceedingly higher you can really lose yourself in it like I'm sure many of you are familiar with doing higher doses of MDMA. Then it becomes more psychedelic on its own and the grounding effect is negated.
If you think one potent drug has a factor of unpredictability, try a 3-variable equation.
Anyway people who want to try this shouldn't just dive in, but rather build it up systematically if you ask me: start with the LSD as most people do when they candyflip (and with reason). When really coming up, or at the peak drop the MDMA, coinciding peaks can be mind-blowing and on paper they certainly are... but I have discovered that I rather get my bearings on one drug before the next one hits. I like it when I can catch the tempo of the flow without it rocketing away from under me. Which doesn't mean that I don't like to rocket away, only gradually! Anyway when the MDMA hits and you get a grip (if that is ever possible in that state) start with bumps of ketamine that let you gauge how strong it is compared to normally, then you can expect the bumps to become lines and to become bigger and bigger until (I'd say quite unexpectedly fast really) strange and magical things are happening that are probably best "dealt with" before complicating matters any further.
I know the approach to just dive in and let it hit you like an anvil, then try to puzzle your way out of the rabbit hole as you go along. It's what I used to call 'fear & loathing' as a verb, and it is basically less responsible and a way to beg for a ++++ or something nasty and unwanted. Tempting fate is another way to put it. After many trips I started to change my preference and felt like asking for something more in particular than 'something big, whatever it is'.