LOTS of experience with Opana and some with neurontin (which is similar to lyrica? i believe), no fentanyl though.
Are you asking about all 3 in combination, or the 3 in general? What are you worried about, an overdose? Thats a pretty hefty combination man, though it does depend on tolerance obviously. eg I could rail 120mg opana and be fine, whereas that'd probably down a guy 2-3x my weight.