Pentazocine stability

[flacky]

If one were to have stumbled upon a few ampules of pentazocine from say the 1950s or 1960s, would they hypothetically be safe to use? Does anyone have any access to literature about the stability of this chemical?

 

[Tchort]

It would have to be the late '60s at the earliest, Pentazocine wasn't marketed until 1968. [/nitpicking]

Analytical Problems with Putrefaction in a Fatal Case Involving Ergotamine and Pentazocine

07/01/1977

Abstract
A drug addict was found dead under suspicious circumstances, but an investigation immediately afterwards did not reveal any drugs in the blood or any pathological indication to explain the cause of death. Six weeks after death a toxicological reinvestigation was requested because of new evidence. By that time, blood decomposition had already started and interfered heavily with normal extraction procedures. This necessitated the use of an acid hydrolysis procedure which revealed the presence of pentazocine and ergotamine, the latter in the form of specific degradation products. This case is of interest as it emphasizes the problems related to the binding of basic drugs to blood proteins or cells, thus rendering them unavailable for solvent extraction procedures. In addition, a search of the literature failed to reveal any other fatal case in which ergotamine was reported to be detectable in postmortem blood.


http://www.astm.org/JOURNALS/FORENSIC/PAGES/5548.htm

Is the amp labeled? Pentazocine Lactate, right? Any other active ingredients?

EDIT: Possibly helpful information

DESCRIPTION

Pentazocine lactate injection is a member of the benzozocine series (also known as the benzomorphan series). Chemically, pentazocine lactate is 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol lactate, a white, crystalline substance soluble in acidic aqueous solutions.


Multiple-Dose Vial:

Each ml contains pentazocine lactate equivalent to 30 mg base and 2 mg acetone sodium bisulfite, 1.5 mg sodium chloride, and 1 mg methylparaben as perservative, in water for injection.


Carpuject Cartridge Unit:

Each ml contains pentazocine lactate equivalent to 30 mg base, 1 mg acetone sodium bisulfite, and 2.2 mg sodium chloride, in water for injection.


Ampul:

Each ml contains pentazocine lactate equivalent to 30 mg base and 2.8 mg sodium chloride, in water for injection.

The pH of Talwin solutions is adjusted between 4 and 5 with lactic acid or sodium hydroxide. The air in the ampuls, vials, and cartridge units has been displaced by nitrogen gas.

http://www.orgyn.com/resources/genrx/D001977.asp

 

[flacky]

30 mg base equiv. of Pentazocine lactate in 1 mL solution as produced by Winthrop Laboritories. Marked with Talwin brand name. It was a pack of 3 ampules which were sent out to physicians to promote the drug (sample packs). I threw out the original packaging though a while ago.

I would post the lot number but I have a feeling it's so old that that would be useless.

Definitely no naloxone. I've read the prescribing information but I didn't quite see anything about longterm storage. It's encouraging to see NaCl and Methylparaben which are pretty stable, acetone sodium bisulfite on the other hand, I have no clue about.

 

[dread]

Tissue damage at injection sites

Severe necrosis and sepsis of the skin, subcutaneous tissues, and underlying muscle have occurred (sometime requiring amputation of limb) at the injection sites of addicts who have received multiple doses of pentazocine lactate (Sosegon, Fortwin). Constant rotation of injection sites is essential. In addition, animal studies have demonstrated that Pentazocine is tolerated less well subcutaneously than intramuscularly.

Sounds nasty...

 

[flacky]

The powder could be dried and snorted. Hypothetically of course.

 

[|3UPE]

what the hell is that shit? some type of Strong benzo/opiate/barbitruate???

 

[johanneschimpo]

^ www.google.com

 

[flacky]

Apparently pentazocine lactate gets very sticky and doesn't like to play nice while you air-dry it. Damn, that was a waste.