Lots of great information on 5-MeO-MiPT, and yet I still can't figure out if it's really something I want to try or not lol. I'll probably give it a shot one day when I know that there are benzos around.
Just A Guy said:
25i-NBOH just worked with me in a way not many other substances have... it was extremely energizing and lent itself to fantasies, dark and light -- was very sexually arousing; visually, it was pretty potent, too -- color intensification, vibrancy, extreme texture movement. The body high was intense. I loved watching movies on it. (Watched The first two Hobbit movies on it, and it was fantastic!) Over the course of one spring and summer, I experienced it more than 50 times. Definitely way out there, but I got used to it. I remember those days fondly -- I really, really liked that substance, even if I did eventually get bored of it from extreme tolerance. The taste was shit, though. But I got used to that too. lol Sometimes I noticed a kind of reverse tolerance to it -- kind of like the first use was a kindling, getting your body primed for it, and then come the second, equal dose, the next day, and take off! I did have a few worrisome effects from it though, like (just like, but not quite as much, 5-MEO-MIPT) I'd cough a lot, and it would bring up all kinds of biley phlegm that was often tinged with blood. Don't know if it was related.
I've got to get some of that again.
Very interesting, it sounds pretty pleasant at that level the way you describe it. Hm, what level of safety are NBOHs generally considered to have? Come to think of it I really don't know, but I know I haven't been hearing about people dying from them left and right like I did with the NBOMes. It seems like it might be something I'd at least want to consider if it ever came my way.
SKL said:
5-MeO-MiPT receptor affinities
note the high 5HT1A affinity
which, I'm not sure off the top of my head, but I'd wager the other isoproypltryptamines regarded as highly erotic share
this is a neurotransmitter associated with sexy time
see flibanserin,
soi disant female viagra
which tbh should be just as effective in men
but also see 8-HO-DPAT
which of late I've had a, no pun intended, hard on for
(see the random-chemicals thread in ADD)
but anyhoo
the purported effects of buspirone &c. to ameliorate the sexual side effects of, e.g. SSRIs are mostly about 5ht1a
vilazodone (Viibryd) which I take is an interesting case
the usual SSRI gives some sexual dysfunction but Viibryd acutally makes me feel more sexual
there are a bunch more partial agonists some of them hardcore neuroleptics some various other things (Ritalin, etc)
a really interesting neurotransmitter site
pretty sure this is where the sexy part of the iPT's comes in though
It's an interesting theory, but I don't know if I can agree with it quite yet. Doesn't basically every tryptamine psychedelic in existence have a (known or probable) significant affinity for 5-HT1A? If it worked through that receptor I would be inclined to think that the feeling would be common to most tryptamines at the right dose, but for me the feeling is very unique compared to them. It is true that
all tryptamines are erotic for me and it wouldn't surprise me if 5-HT1A plays some role in this, but those isopropyl tryptamines, and 4-HO-DET/4-AcO-DET for me, have a distinct course of effects which involves physical, psychological, and even perceptual changes totally unlike the others. By comparison, 4-HO-DPT, which should likely also have a very high affinity for 5-HT1A based on the dipropyl tail and the fact that DPT has twice the 5-HT1A selectivity of 5-MeO-MiPT in the same set of data, completely fails to produce this effect for me. It did produce sexual visuals and things of a style comparable to any other tryptamine for me, but it very obviously lacked this specific sexual stimulation I associate with those particular chemicals, and any of the visual changes or fantasies that accompany them. On the other hand, I find it noteworthy that DiPT also produced the least, possibly not even active level of this stimulation of any of the isopropyls for me, but that same data again lists it as having at least as much 5-HT1A activity relative to 5-HT2A as DPT.
I like to compare molecules too.
I was absolutely fascinated to find everything I could about the dopamine receptor binding data of N,N-dialkylaminotetralins at one point. The way that some activity is retained with DPT seems to suggest to me that their structure-activity relationships with the tryptamines are relevant beyond just serotonin receptors as well.
Lately, I've been getting into a bit "darker" of a theory. Look at all of these beautiful molecules:
Every single one of these drugs is an antimuscarinic agent, and I think it's pretty obvious what the common factor is, particularly given that this is acetylcholine:
In addition, the same data referenced before also lists DOB, 2C-B, 2C-B-FLY, 2C-E, Aleph-2, 2C-T-2, and DOI, which of course all have their own amine tails, as having variable affinity for all five muscarinic receptors. No data of the sort was detected for the tryptamines tested for the same study, but I think it's noteworthy that the tryptamines tested were all significantly less potent at 5-HT2A than the phenethylamines, and yet testing was equally stopped for all at 10,000 nM. This might be fine for something like DOB which was 23.1 nM at 5-HT2A and 1151.5 nM at M3, but consider that DPT was 2579 nM at 5-HT2A and it becomes clear that it could have way more selectivity for M3 than DOB and it still wouldn't even remotely register in this test. I think that's important also considering that people often dose what could be considered proportionally
much higher on tryptamines than they do on phenethylamines, so any outlying receptor affinities seem like they could be a bit more likely to matter still.
Basically, my point is that I have a suspicion now that tryptamines could be binding to muscarinic receptors as well, whether positively or negatively, though I'm inclined to notice similarities to antagonists more because I have had the unfortunate experience of becoming familiar with diphenhydramine. I do find some of the "darker" visual aspects of 4-HO-MET and 4-HO-DET especially to resemble deliriants in some ways, in more simplistic design as well but also like with 4-HO-MET is the only drug I've ever taken that's made me seem the same rainbow spiders I saw on diphenhydramine, and 4-HO-DET has honestly made me see the same kind of demented shit you hear about from tropane visions at times except with an extreme psychedelic twist, and at the same time I was completely insane and even though there were entities in the room with me. I think it's also worth noting that, though I never experienced it on diphenhydramine, tropanes have also been historically associated with sensations of flight, and this goes back to what I was saying I've experienced on 4-HO-MET, 4-HO-DET, and MiPT, and what is referenced in TiHKAL about 4-HO-MiPT. There is just a lot of overlap the more I try to find it in different places, and it's never like all of the effects of deliriants at once, but I think it's worth considering that diphenhydramine and tropanes non-selectively block all five muscarinic receptors, whereas a lot of these amine tail molecules like the phenethylamines seem to have modest to extreme selectivity for M3. I find this very fascinating myself, as M3 receptors would probably not be the ones associated with most of the physical dangers of deliriants, but seem likely to me based on the scientific data to play some role in the cognitive effects. But that's getting into a whole other discussion....
The other main point I'm trying to make here is that I also love trying to figure out how which molecules do what things, but I also think that there needs to be some reservation with the amount of knowledge we currently have. As I see it, that amine tail alone is probably sufficient to cause a wide array of binding to serotonin, dopamine, adrenergic, histamine, and acetylcholine receptors, and probably others too, and there will probably be relationships between the same bases (like two dipropyls, two diethyls, etc.), but that those relationships will probably be highly complex in their own right. Like, I would wager that almost anything with a dipropyl tail could be sexual due to dopamine receptor activity as much as it could be due to serotonin receptors, and honestly even antimuscarinic drugs are sometimes associated with an increase in sex drive. But that's just my opinion on the subject....
Personally, when it comes to the isopropyls, I won't be surprised if it turns out to be related to a site that tryptamines have not been tested at yet. It'd be interesting if it's not too... but that's just my guess so far from my subjective experience.
