☮ Social ☮ [PD Social Tripping Thread] NEW! Gather here for swirly talk

[pharmakos]

how long have you been with your girl then? like a year and a half now? ready to call her your girlfriend yet?

 

[Xorkoth]

Yeah almost a year and a half, we got together in mid-September 2014. So in March it will be a year and half. Yeah I call her my girlfriend now. I never asked her or anything either, we just started calling each other that. It's been a natural progression, and things have gotten much more serious now. I see no earthly reason why we would break up... I'd be a fucking idiot to break up with her, she's as close to perfect as I can imagine. It's pretty much the exact opposite of my last relationship, to an almost weird degree. I feel like I got rewarded by the universe for successfully dealing with the last one, like relationship karma.

Speaking of my last relationship, I am going to call my ex shortly, and talk to her about a few things, primarily about getting the divorce underway. We haven't talked or been in contact with each other in a long time, it's probably been 7 or 8 months. I have a fair amount of anxiety about it. I also have to tell her that I took her off my insurance, which I did without telling her first because it was the last day I had to sign up... I meant to call her then but I put it off because I would prefer to not talk to her. It's weird, after 2 years since she moved out (and since I've seen her), I'm still afraid of her. I know I have no reason to be but the thought of calling her makes me feel fear.

 

[Beefy]

I'd figured I'd say heeeeeey, along with the aliens or "ETs" that you get as a side effect of a mix with lucy+shroomage that one's currently experiencing, So I've heard from another post...

 

[TurnedOnTunedIn]

HEEEEEEEY Beefy.... I posted this whole post in the wrong thread first -_-... so... yup

Also... lingering aliens as a side effect of piercing the veil too deep... I like it! I want to discover if these entities are symptoms of psychosis or reflections of consciousness or a part of the fabric of reality we may not understand as humans, maybe psychedelic drugs drop those brain filters that normally tune out those dimensions....

Hello all! First post! I suppose I'll post in the introductory section to introduce outside of this thread, or maybe I should just do it now briefly to provide some context!

I'm nearly 25, having browsed Bluelight for at least the last 6 years and Erowid for the last ten. I have played with maybe 30 different RC's, 1/3 being psychedelics(I know NOT ENOUGH)....

Anyways I'm trying to get at, I just posted the following to Reddit to hopefully gain some insight, started reading this thread and decided "Okay let's get into posting on BL".....

Title - Help integrating 300mics - Experienced A LOT! Light Flashes, Telepathy, Noosphere, etc.

"I had been studying Timothy Leary's "Programming the psychedelic experience" for nearly a year only to realize "I knew nothing"(as I said to myself coming down).A friend and myself took 300 mics and experienced such significance, so much spirituality and insight into what I thought was so silly before but my actual soul as opposed to the ego, gaming playing personality that is my identity....
Flashes of light at the most significant moments of consciousness stripped bare, naked, high res paradigm shifting realizations... It was literally as if the flashes of light happened to let me know to remember that paradigm shifting realization...
I felt so connected to everything, I understood my brain as an organic neural net arising out of low level organization matter that through a billion years of evolution self organized into a sentient being that perceives itself as living off a planet.... To experience awareness allows matter to have existed... The earth is a biosphere and global consciousness, planetary consciousness, humans are a phase of existence of this planetary entity.... You can tap into that by stripping bare the normal filters that tune down the resolution and frequency of the input signals coming in... These filters are there because otherwise we'd go mad...
All of this happened while feeling highly telepathic with my tripping partner, it was so beautiful, there were moments of clarity... We were oscillating between feelings rapidly but we ended with a lot of "seeking rebirth"...
I would just like some direction in where to continue reading so I can understand this numinous realm and bring back souvenirs for the rest of us to consume...."

There's so much information and data out there for me to consume, but the curation is off... I don't know where to keep digging deeper at to help me understand psychedelics/psychedelic experiences so I can just.... IDK... understand the effects of psychedelics more so I can tap into it? I don't know what I'm trying to ask, I genuinely just want to ponder the universe and keep reading....

I'm pretty sure different psychedelics allow you to enter different spiritual realms(and human realms without the billion year old evolutionary filters that block the data coming in, ya know, because psychedelics boost the fidelity, the resolution, of the input signals... jesus am I computer? My brain is like 400 different computers, each with a different function.... oh man...) that is given that spiritual realms exist(as ayahuasca is kind of pointing to eh?).....

To give you some more context, I haven't tripped in years and boy did I forget about the entire reason I got the seed of life tattooed on my back to remind me of the spirituality 4 grams of penis envy's showed me.....

I know I sound lost and scattered, but isn't that part of coming back from the numinous without proper orientation?(well maybe not quite but still )

Oh and this was a week ago on the "wolf" full moon(on accident), and I'm currently on 12.5mics and a 'Bio-Berry'(bio-jesus/hashberry bho) hash hit with two sweet and spicy tasty tea's! Been getting more in tune with my body/mind lately(body-mind, we are body-minds)... Ranting...

I'll try to be more focused and directed in my future posts..... for whatever reason I felt the need to type that.... "a heightened sense of awareness of one's own feelings and drive. "

..........

 

[pharmakos]

the two different socials is just a general guideline, brother. your post really could have fit in either one, no big deal if there's a bit of bleed over between the two.

 

[TurnedOnTunedIn]

the two different socials is just a general guideline, brother. your post really could have fit in either one, no big deal if there's a bit of bleed over between the two.

Right on peaceful brethern!

 

[xammy]

Oh my this 5-MeO-MIPT is nice

 

[vortech]

Swirlies. I'm so in love with life when I have some 3-MEO-PCP in my system. I must accept the reality of this tool in my life.
I'm in a rehab-kind-of program at the moment, grounded to AA and NA, and I have been honest with everyone there. I tell them with a straight face I know what my line is between medicine and drugs, use and abuse, and no it's not the line imposed by the program. My purpose this year is becoming clearer. The path is to continue developing dissociative therapy. Sure, it is a beast I respect. It is a strong beast that I can employ to defeat lesser beasts, such as alcohol or opiates. I do not lose my identity, and the day is saved.

 

[TheAppleCore]

^ I'm glad to hear that you're discovering your purpose vortech! Dissociative therapy, godspeed!



WOW I had a really satisfying trip this evening... I am absolutely glowing!!! I pushed the dosage a bit further with the 4-HO-MET and 4-AcO-DMT combination, and I'm completely convinced that these chemicals have a special synergy, where the whole is greater than the sum of its parts. I really should write a trip report for this one.

 

[Cream Gravy?]

Day drinking and mardi gras on fuckin glavy bros. Almost as wild as ren fest. I'm at this point in life that I just don't remember a lot of things. How the fuck did this happen? Sometimes I think that government lets us drink because they know it'll keep us at bay.

Party on, PD.

 

[Xorkoth]

Hey TurnOnTuneIn! Welcome to PD! It's great returning to psychedelics after a long break, isn't it? I did that in 2014, after not having any psychedelics since 2011.

I'd figured I'd say heeeeeey, along with the aliens or "ETs" that you get as a side effect of a mix with lucy+shroomage that one's currently experiencing, So I've heard from another post...

Heeeeeey

Swirlies. I'm so in love with life when I have some 3-MEO-PCP in my system. I must accept the reality of this tool in my life.
I'm in a rehab-kind-of program at the moment, grounded to AA and NA, and I have been honest with everyone there. I tell them with a straight face I know what my line is between medicine and drugs, use and abuse, and no it's not the line imposed by the program. My purpose this year is becoming clearer. The path is to continue developing dissociative therapy. Sure, it is a beast I respect. It is a strong beast that I can employ to defeat lesser beasts, such as alcohol or opiates. I do not lose my identity, and the day is saved.

Right on man, it's good to feel your purpose. I'd say just proceed with the greatest level of objective oversight of yourself that you can. Dissociatives can be an addiction as well and you don't want that, but I fully support the usage of substances to increase quality of life, I do it myself with psychedelics/dissociatives. If you can be honest with yourself about the reality of how/why you're using them, you can ride that line and stay behind it and they really can be life-enriching.

WOW I had a really satisfying trip this evening... I am absolutely glowing!!! I pushed the dosage a bit further with the 4-HO-MET and 4-AcO-DMT combination, and I'm completely convinced that these chemicals have a special synergy, where the whole is greater than the sum of its parts. I really should write a trip report for this one.

Nice man, I did that in a combo once, my first truly high-dose tryptamine experience actually, this past spring. I took 35mg of 4-AcO-DMT and 12mg of 4-HO-MET, along with 40mg of MXE. It was a beautiful trip, overwhelmingly visual (in a good way). I felt like I was exploring the universe, and music was godly, as if it was a physical thing that I could perceive with all of my senses and more.

Day drinking and mardi gras on fuckin glavy bros. Almost as wild as ren fest. I'm at this point in life that I just don't remember a lot of things. How the fuck did this happen? Sometimes I think that government lets us drink because they know it'll keep us at bay.

Party on, PD.

Yeah alcohol is fun, but it's not good for your brain. I hate it when I get the spotty memory.

 

[Cream Gravy?]

Yeah alcohol is fun, but it's not good for your brain. I hate it when I get the spotty memory.

I'm feelin that this morning. I drank a shit ton Friday night, woke up being confused as to where I was, then proceeded to drink all of Saturday from about 2pm-2am... finally got home late last night. Crazy thing is, just the entry to Mardi Gras cost 20 bucks, and I only had 25 bucks on me the whole time. Out of some miracle of comradery, or perhaps the drunkenness of all those I was with, I got people to buy me everything all of yesterday. I didn't even ask for anything. I've never seen so much kindness in years. Had some real deep conversations with a lot of people I hadn't seen in ages, and others I see all the time. Even ran into a chick I knew from high school who I used to have a thing with; that was extremely awkward because our mutual history was kinda fucked up, and it really threw me for a loop.

Anyways, it was a lot of fun, and I've got nothing this small bowl of dank I toked can't fix at the moment, so for the time being the hangover is at bay.

 

[yepyepwoah]

@240sx, of course the government lets us drink to keep at bay. It is the dumbest, most mind constricting drug there is, and conviently the only really intoxicating one available to us with no prescription/at all.

@vortech, thats co you were honest with the people im the program. I had to go to AA for a while. I kust kept my mouth shut though because I was bit about to say " hey guys I love psychedelics, j think they makd life better, and make me feel more sober with regular use. Oh hry your founder Bill felt the same way about LSD. Also, he was a liar and a charlatan, and a lot of yoi guys are self righteous nuts".

I just stopped going and scammed the system myself. Fuck em

 

[Img_9999]

@240sx, of course the government lets us drink to keep at bay. It is the dumbest, most mind constricting drug there is, and conviently the only really intoxicating one available to us with no prescription/at all.

I generally find that "My drug of choice is so much better than yours" attitude to be of bad taste, but honestly I very much agree with you on this.

A couple of weeks ago I attended a three days music festival, with music going all day all night and obviously there was a point at night where every single soul in the place was pretty much fucked up in some form. I tripped one night there on 1P-LSD, and I remember that I couldn't stop thinking how the people acting the dumbest, most annoying, and the only ones that were bothering someone else were the people that were extremely drunk. The festival was in a beautiful place amidst the woods nearby the countryside, so minimal respect for the environment was to be expected, but lots of beer cans and jugs of wine were to be found in the floor, which made me angry with the people drinking.

What shocked me the most was the contrast between the people that were just high, or tripping, or rolling. Those were bothering nobody. So I couldn't wrap my tripping mind around the fact that the people "breaking the law" were the ones being the less harmful, whereas the people on a legal drug were the ones being loud and messy.

Just a rant, ha. But yeah, I like an occasional drink, it's just that I can't really understand what society sees as dangerous on substances that make you care about people and ideas and health and the environment, whereas seeking to drink until getting smashed, throwing up and acting careless is allowed. Seems fucked up to me and I can't really comprehend it.

 

[psy997]

It's funny, I actually just learned that alcohol has been used for spiritual purposes in the East for thousands of years. Yet here it's incomprehensible that it can be anything but negative because of the way we over-consume it.

 

[Xorkoth]

I recently acquired a pretty large amount of methylone, and I find it compulsive. So I've done it too much since I've gotten it, and it's been a couple of weeks. Yesterday I went to hang out at my girlfriend's house after work, and I decided to do a relatively small dose because I was feeling pretty low-energy. Instead of a nice buzz, I got quite anxious and felt very weird, decidedly unhealthy and bad feeling. It made me feel pretty off so I ended up drinking like 6 beers, which helped a good bit in the moment but made it worse in reality. We had a nice time, laughed, snuggled, talked about stuff, but this morning I feel drained and kind of sad. I also have a spotty memory of the night, not like sections missing but just not really remembering what we were talking about. Last night I was functioning normally, I remember that we had some really cool and deep conversations, but I just don't remember what they were about now. That makes me feel fairly shitty.

I'm already feeling better than I did when I woke up. But this is a real wake-up call to me. Fortunately, the results of yesterday made it so the thought of methylone is not appealing. I really need to just have self-control with that, empathogenic stimulants are the one thing I keep finding myself having a hard time controlling, when I have them. I'm happy with my rate of usage of psychedelics, and weed, and alcohol, but not with things like methylone. If I don't have it, it's fine, but if I have it, I convince myself to take it a lot more often than I should. It's funny, last night I had all these really vivid and intense dreams, I remember them today better than I remember the being awake parts. The most intense one was one where I was taking kratom, and I went through this whole process of thought about that... the setting of the dream was such that I had taken it also the day before, and I was obsessing over whether that would produce withdrawals. I felt all this shame that I had dabbled in the opiate path again. Almost 2 years ago I took ibogaine to get out of a 10-year opiate addiction, and in reality I have not touched an opiate since nor wanted to - but sometimes in dreams I do it and it generally serves to reinforce my strength on the matter once I wake up because of the negative feelings it reminds me of. I suppose this was no different... my subconscious mind sent me a warning about addiction. In this case it applied to methylone.

Lesson learned, I'm glad I have developed a higher level of oversight over myself than I once had. I'm sure I'll feel fine tomorrow, and I'll save the methylone for appropriate times.

 

[Kaleida]

That's too bad about the methylone Xorkoth, but it's good that you can recognize it for what it is! That does kind of sound like what happened to me from overusing MDMA too.... I wonder what it is about messing with serotonin transport? I have to say that when I was at the height of my MDMA usage I also found myself losing control of my intake surprisingly often, definitely more so than I did for things like stimulants. I wouldn't really say I found them to feel addictive in the same obsessive way though, but more like they just made me not care that I was going overboard sort of like alcohol....

I'll bet you were relieved when you woke up from that dream too! I've had, not drug related in that way at least, but similar behavioral relapse dreams like that before where I'm just so disappointed in myself or getting really anxious about what I've done.... It's always wonderful to wake up and realize that it's just a reminder to stay on the right path and not just another fuck up. The mind is quite the prankster sometimes!



On the subject of alcohol and spirituality, I actually find high doses of alcohol to honestly feel more like psychedelics than most other non-psychedelic drugs I've used. It has a similar emotionally freeing effect to a really positive trip for me, and it does distort proper perceptual processing a lot more than most other non-hallucinogenic drugs I've used, and especially in the department of making me lose awareness of time.... I also find it to have a euphoric synergy with cannabis that makes it feel even more quasi-psychedelic to me, and when I'm particularly wasted it starts to also feel similar to threshold hallucinogenic doses of Amanita muscaria to me, though without the colors. I think, like most things, it's probably all just about your perspective, and what you personally need the most.

However, I do have to agree that people seem to do fucked up stuff far more often while drinking than when doing most other drugs from what I've seen.

 

[szuko000]

I would just like to say after about 3 years of no psychedelic use i finally got to candy flip on about 3 hits of LSD and 150mg of MDMA, all tested all good. In the past years I have become a heroin addict was in a relationship with a girl for about 6 years and it all ended so well (being serious we are both clean and now just best friends smoke with her daily but we are just friends now) and my younger brother is out of prison (same deal former junkie crack head) we went to a "Lotus" show and it was amazing. They are like an electronic jam band if you will.

I forgot how much i love candy flipping and how it literally feels like a different form of myself. So i was able to trip around my parents (i actually look and act 100% normal on LSD so i wasnt worried) and get to the show after the come up as i get sick during the come up and hate moving around. But man did that experience reinvigorate my zest for life. Somehow through getting my ex g/f and myself addicted to dope and then clean, myself twice, i had forgotten how perfect candy flipping in a very active environment is for me.

The experience really made me feel lucky to be alive. That and the mushrooms i took during a blizzard 2 weeks ago... I forgot how much psychedelics agree with me and how much i love them. Its good to be back!

 

[Xorkoth]

That's too bad about the methylone Xorkoth, but it's good that you can recognize it for what it is! That does kind of sound like what happened to me from overusing MDMA too.... I wonder what it is about messing with serotonin transport? I have to say that when I was at the height of my MDMA usage I also found myself losing control of my intake surprisingly often, definitely more so than I did for things like stimulants. I wouldn't really say I found them to feel addictive in the same obsessive way though, but more like they just made me not care that I was going overboard sort of like alcohol....

Yeah, you hit the nail on the head. It's like they make me not care that I'm doing it too much, when I have it, because it feels good in the moment. But unlike, say, opiates were for me, when I don't have them, I don't care. It's a weird kind of compulsion. Fortunately I really have no desire to use it now or for a good while. That last experience was pretty jarring.

I'll bet you were relieved when you woke up from that dream too! I've had, not drug related in that way at least, but similar behavioral relapse dreams like that before where I'm just so disappointed in myself or getting really anxious about what I've done.... It's always wonderful to wake up and realize that it's just a reminder to stay on the right path and not just another fuck up. The mind is quite the prankster sometimes!

Yeah, therein lies the power of those dreams for me. During them I feel the full range of negative emotions associated with addiction, the guilt, the shame, the insane rationalizations, and I wake up and am so relieved it's not reality. It makes me feel stronger, because it's a visceral reminder of the negatives of addiction.

On a lighter note, I recent;y received a good 3 grams of nice quality MXE in a trade, my friend had some from before this current issue happened. I've had it for a little bit but tonight, feeling stressed (about various things I haven't talked about here yet) and a little down (presumably from the methylone overuse), I decided to test it out. Me and 2 of my very good friends each took about 20mg, followed by a booster of 12mg an hour later. I felt the magic that I used to feel from it, without adding any psychedelics. The night was great, a real stress reliever, I have some perspective now. It wasn't a full-on experience, but I felt myself touching on that MXE flow state I remember so well. All in all, a beautiful experience, and I'm glad I have MXE back in my arsenal. I am planning to IM DPT along with some MXE sometime relatively soon, I've been waiting for MXE or ketamine for that.

The experience really made me feel lucky to be alive. That and the mushrooms i took during a blizzard 2 weeks ago... I forgot how much psychedelics agree with me and how much i love them. Its good to be back!

Yeah, psychedelics are really special. They don't agree with everyone, but for those they do, you really can't beat a good trip.

 

[Kaleida]

I would just like to say after about 3 years of no psychedelic use i finally got to candy flip on about 3 hits of LSD and 150mg of MDMA, all tested all good. In the past years I have become a heroin addict was in a relationship with a girl for about 6 years and it all ended so well (being serious we are both clean and now just best friends smoke with her daily but we are just friends now) and my younger brother is out of prison (same deal former junkie crack head) we went to a "Lotus" show and it was amazing. They are like an electronic jam band if you will.

I forgot how much i love candy flipping and how it literally feels like a different form of myself. So i was able to trip around my parents (i actually look and act 100% normal on LSD so i wasnt worried) and get to the show after the come up as i get sick during the come up and hate moving around. But man did that experience reinvigorate my zest for life. Somehow through getting my ex g/f and myself addicted to dope and then clean, myself twice, i had forgotten how perfect candy flipping in a very active environment is for me.

The experience really made me feel lucky to be alive. That and the mushrooms i took during a blizzard 2 weeks ago... I forgot how much psychedelics agree with me and how much i love them. Its good to be back!

Good deal. Not exactly the same, but your story reminded me of a friend of mine who waited years after trying other drugs to try MDMA. The reason he finally tried it when he did was because everything in his life in that time had just been going so well and as he had hoped, and we were just having an awesome night with friends as it was and he decided that he just wanted to celebrate everything and push the enjoyment as far it could go. Of course, he had an amazing time, and found the experience incredibly therapeutic as well.

Congratulations on your life going so well too. And glad to have you back in the psychedelic scene as well. Sounds like you've got some good new experiential knowledge to bring to the table this time around too!

Yeah, you hit the nail on the head. It's like they make me not care that I'm doing it too much, when I have it, because it feels good in the moment. But unlike, say, opiates were for me, when I don't have them, I don't care. It's a weird kind of compulsion. Fortunately I really have no desire to use it now or for a good while. That last experience was pretty jarring.

Yeah, therein lies the power of those dreams for me. During them I feel the full range of negative emotions associated with addiction, the guilt, the shame, the insane rationalizations, and I wake up and am so relieved it's not reality. It makes me feel stronger, because it's a visceral reminder of the negatives of addiction.

Interesting juxtaposition here, heh. One can be negative because it's so positive, the other can be positive because it's so negative. I definitely agree on both fronts though. I'm also really happy that empathogens seem to be able to turn you off to them when the time comes to put them down for a while.... That was definitely one nice thing about MDMA too, despite being probably the drug I abused the most, it was also one of the simplest to stop thinking about once I stopped.

On a lighter note, I recent;y received a good 3 grams of nice quality MXE in a trade, my friend had some from before this current issue happened. I've had it for a little bit but tonight, feeling stressed (about various things I haven't talked about here yet) and a little down (presumably from the methylone overuse), I decided to test it out. Me and 2 of my very good friends each took about 20mg, followed by a booster of 12mg an hour later. I felt the magic that I used to feel from it, without adding any psychedelics. The night was great, a real stress reliever, I have some perspective now. It wasn't a full-on experience, but I felt myself touching on that MXE flow state I remember so well. All in all, a beautiful experience, and I'm glad I have MXE back in my arsenal. I am planning to IM DPT along with some MXE sometime relatively soon, I've been waiting for MXE or ketamine for that.

Sounds nice, I'm glad you got some relief. I still haven't tried MXE myself, but I would love to hear about how that combination with IM DPT goes!



----------



I think I'm going to take this talk of empathogens as an opportunity to ramble a bit about something I've been researching lately.... I've really been trying to understand the impact of serotonin and serotonin-like molecules in the brain, and first of all I found something which I personally find to fairly intriguing: was anyone here aware that serotonin causes reverse dopamine transport just like amphetamine? I definitely wasn't. From what I can tell so far, studies have failed to reverse this effect so far with serotonin receptor antagonists, and given that it's known that serotonin can also act as a substrate of the dopamine transporter in high concentrations, I have to wonder if it is even literally doing exactly what amphetamine does, as opposed to just indirectly downstream of its initial actions....

That seemed like kind of a ridiculous thought to me at first, but, lo and behold, then I found that tryptamine, N-methyltryptamine, and N-ethyltryptamine are also dopamine releasing agents, the first two with affinity comparable to alpha-methyltryptamine (164 nM for tryptamine, 321 nM for NMT, 6660 nM for NET, and 78.6 nM for AMT). Likewise, all of these chemicals also act as more potent serotonin releasing agents, and less potent norepinephrine releasing agents relative to dopamine. So, this actually all kind of makes sense I think if you consider that it could reflect that fact that serotonin also acts most potently as a serotonin transporter substrate, only as a dopamine transporter substrate in high concentrations, and that it possibly has too low affinity at norepinephrine transporters to matter in normal states.

Interestingly, tryptamine, NMT, and NET, again like AMT, all also have activity as 5-HT2A agonists in those tests comparable to their affinity as serotonin transporter substrates. I think that makes it compelling to question then why tryptamine and NMT seem to have so little human activity compared to AMT in the few tests that have been done, but I would note that both are described as being capable of producing at least mild, extremely short-lived psychedelic effects in TiHKAL, and so I have to wonder if the primary difference between them is just the fact that they are metabolized incredibly rapidly, even more so than DMT, requiring larger doses and leaving only a very short window of opportunity to look for effects, compared to AMT which is obviously very slowly metabolized and gives you plenty of time to explore the state you're in.

However, there is something that I think is even more fascinating about the study that I'd like to touch upon now.... As a rule, they found that increasing the bulk of the molecule seemed to detract from the releasing properties, particularly on the tail. 5-MeO-NMT and 5-MeO-NET were less potent and more selective serotonin releasing agents, whereas NiPT, 5-MeO-NiPT, and interestingly 5-methoxytryptamine were only moderately or weakly active serotonin reuptake inhibitors. There also seems to be a high bias against having two tail substitutions, as DET, DPT, DiPT, 5-MeO-DMT, 5-MeO-DET, 5-MeO-DPT, 5-MeO-DiPT, and psilocin only showed reuptake inhibition properties at monoamine transporters (mostly for serotonin, but DPT, DiPT, and 5-MeO-DPT were also active for dopamine, and DPT only also for norepinephrine), and MiPT and 5-MeO-MiPT were not active in any transporter tests.

There does seem to be an exception though, as some may have noticed from that list.... Despite its two methyl groups, DMT still showed activity as a serotonin releasing agent, primarily selective but with comparably weak affinity for norepinephrine release as well. It and bufotenin, which is more potent and selective for serotonin transporters, were the only two tryptamines with two tail substitutions that were able to retain this releasing agent property. Isn't that intriguing? One important question I see it bringing in is: if DMT acts as a serotonin releasing agent, does it somehow protect against serotonin syndrome? It has quite an array of receptor affinities and some receptors have shown to protect against the symptoms before, so I don't think it would be entirely impossible, and clearly it would be necessary to explain how DMT can still be so safe to take in relatively high doses, and particularly in combination with MAOIs. On the other hand, I wonder if bufotenin might lack some of this activity, given its higher potency relative to 5-HT2A agonism but also higher efficacy than DMT at that receptor.... At least from personal experience, I can say that a bad bufotenin body load is the closest I ever came to feeling like my body was just entirely malfunctioning and getting those kinds of symptoms, it was not fun in the slightest....

Aside from that though, I think it just also opens up some interesting avenues for theorizing. One that comes to mind is that one of the things that separates DMT from other traditional psychedelics could be this more widespread and disinhibited serotonin release, which could have effects that simply activating serotonin receptors like psychedelics do may not... such as its dopamine releasing agent effects. Particularly, I wonder if DMT taking up all the serotonin transporters could not only increase the available concentration of serotonin to levels that allowed it to bind to dopamine transporters, but also make it more likely to bind there anyway since its default transporters are not available? It just seems to me that one actually realistic explanation for the effects of DMT that make everyone (including schizophrenic people I know who've used it) want to compare it in some ways to a model psychosis could be that it induces a whole brain state which endogenously mimics the effects of amphetamine psychosis, and considering that serotonin is involved in social interactions and reward I don't think it would be too far of a stretch either to suggest that some of the emotional and cognitive nature of the trip could be derived from the fact that this amphetamine-like psychosis is being driven by the mechanisms involved in that social interaction as well, like especially in relation to how entities may greet you and want to show you things or tell you what you want to hear and other such things....

Just some thoughts I wanted to get written down, and I thought they might generate some interest here. Honestly, even just thinking about the euphoria I've experienced from DMT makes it not that surprising that it could have this activity, but I've also felt connections between DMT and other substances that made me question how accurate my judgments could really be, such as a few trips I've had on it particularly with higher doses that started off feeling like and then had some visuals almost identical to salvia. But, given what I posted recently about the DALT tryptamines and possibly DPT showing activity at kappa-opioid receptors as well, perhaps I was not too off about that either.... Who really knows what the hell is going on these days?

I'm done now. Time to start the day.