I mean - why U-47700? Because it can be made in 1 step from commercially available chemicals
why isophenidine? Because it can be made in 1 simple step at RT using cheap reagents
Like they were saying in the thread about 4-HO-5-MeO-DMT, Shulgin described it's ten step synth as "frightening"
But to this day, I get withdrawals from it almost immediately. And I fall into this usage pattern where I never feel good, I either feel almost normal, but still slightly withdrawaly, when I've just done some, or I am fully feeling withdrawals. I get cranky and moody and it just sucks so much, but the restlessness is so bad, and despite it not doing much for me in a positive sense, I compulsively redose to try to feel okay.
Man, despite not having ever been dependent on kratom, I also now get what I assume are near instant withdrawals. As soon as it wears off, I get an instant, untreatable pounding headache. I feel mildly sick to my stomach, drained of motivation and energy, generally unwell, and my body feels crappy. I use it maybe once every 3-4 weeks. When I'm on it, I'm usually focused and driven, but also quite irritable. I guess it's a blessing, as it makes me pretty disinclined to do it unless I really feel awful or have a majorly unpleasant task to deal with (like my taxes.)
The actual experience for me was unusual, from what I have read about. I did a combination of pure ibogaine and total alkaloid extract, so I got the full range of alkaloids but in a different ratio than eating the root powder. I found it physically comfortable, actually my body felt really good, and I was basically dreaming whether awake or asleep for 3 days and nights.
My friend described their ibogaine flood dose that way. Their second was as harrowing as the stories I usually hear.
The number of deaths from either ibogaine or 5-MeO-DMT is, to my knowledge, extremely small.
I think the deaths from 5-MeO-DMT are usually due either to vomit aspiration, drowning, or drug interactions. Ibogaine affects heart rhythms in multiple ways, of which QT prolongations is but one. I have not heard good reports of people being treated effectively when it gets bad. Lots of drugs cause QT-prolongation. Some (Benadryl) don't seem to be that risky. Others (methadone) are apparently roughly equivalent to ibogaine. The number of recorded ibogaine fatalities when I last checked was 17, although there are undoubtedly more. I've read of at least one in a pseudo-clinical setting where it was not reported because of concerns regarding the surviving partner's life insurance payout. The fact that deaths can occur days later also complicate attempts to measure them. I think that efforts to screen for risk factors (dehydration, methadone use, pre-existing heart conditions) are a positive step, but I don't know that we'll have good data for many years as to how effective they are at completely screening out risk.
I almost invariably put eight in mine.
After ten years of tripping, my friend finally tried nitrous last night. They had an experience that I'd read about plenty, but neither of us had experienced before: they took 20mg of miprocin, and after two hours had not gotten above a very, very weak +. They are exceedingly experienced with miprocin, and knew that 45min was the absolute longest they should ever expect to wait, even on a full stomach. They were frustrated and were tempted to take a 5mg booster. I said, just take the loss and call it a night. I suggested taking a few balloons of nitrous, as that will often kick my brain into recognizing that it's tripping. I told them to take several lungfulls back to back, holding them in, but apparently holding one cartridge worth for ten seconds was plenty intense. It never got them going. They vaped some EPT sullenly and gave up.
Three hours after dosing, they suddenly started tripping. Only a light, attenuated ++ likely due to tolerance, but a big shift. Very weird.
The following morning, a different friend told me that they couldn't sleep, so they hit their wax pen. Ended up in hyperspace. Full moon? lol
lots of early DPT reports (like the ones Xorkoth referenced) used incredibly high dosages, and I honestly think that's a huge part of where its reputation comes from.
My one dose with it was on the low end and while it was not the craziest of experiences by any means, it definitely left me with an evil aftertasted that lasted all week.
with more realism (typical of base vs 4-substituted tryptamines for me) and a complete lack of their stimulation. Although it also had a more alien and demonic vibe like 4-HO-DET
I wanted to revisit 4-AcO-DET. I haven't had the 4 hydroxy sub, but so far this one doesn't feel all that weird or alien. I quite liked it the two times I tried it.
5-MeO-EiPT, which is rather more unique for me.
5-MeO-PiPT is pretty different from the -MiPT in my experience, too.
I did try 4-ACO-DET but only once.
Let me know if the hydroxy sub is any different if you ever try it.
AMT is another one of those "I must try before I die" drugs, but i havent been able to find any yet

I'm sure it'd be one of my favorite drugs. It sounds sublime.
I hope you dig it. My friend and I...well, we didn't much care for it. Literally everyone else that I've ever talked to loves it.
The deaths are due to Long QT Syndrome, and it seems that you can almost entirely rule out the risk if you get your heart tested beforehand, to ensure you are not at risk.
I'm honestly not sure that I'm confident making that claim, although I confess that I haven't kept up with the research. It's tough, what with it being aggressively scheduled. Quality research that involves human experimentation and the risk of death, well that's hard to do. I often think that we often tell ourselves stories about things being safe to make ourselves feel better and then just repeat them. Remember the handwashing public messaging and sterilization teams during the early pandemic, all there to make people feel better even though we knew that touch transmission wasn't a vector? I really want ibogaine screening to work, but I just don't really know if it does.
im planning on just doing it once in awhile
Man...