In therapeutic doses, I don't see why it would. However I would probably avoid AMT. As far as I remember, I think some indigenous tribes utilize tiny doses of tropane alkaloid containing plants in ayahuasca but that is anecdotal and I wouldn't want to fuck around with MAOI activity and tropanes, or even releasers and tropanes, to be safe. AMT is unique dangerous in terms of interactions, among psychedelics. Well, not totally uniquely (I think 2C-T-7 shares some similar concerns), but more dangerous than others.