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☮ Social ☮ PD Social: Cross-dimensional chatter. Now featuring mesphereomeantoliopeme.

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panic in paradise

the universe has but two forces.... creation and entropy.... the fact that anything exists today means that the force of creation outweighs the force of destruction...
 
Muffin has her light gloves on lol. Our roommate seemed to enjoy the 2C-C. Hopefully he'll delve into the other realms with us in the future. (DMT should be ready tomorrow or the next day! Doing some cooking if you catch my drift...) 2C-D and MDMA really do make a good combo; almost as good as candyflipping, though shorter. Started with 130mg MDMA and 30mg 2C-D; dosed simultaneously since we didn't want our roommate to have to wait for us to come up on the MDMA before we dosed our psychs. Smoked some decent bud while waiting...comeup was fantastic, most intense and pleasurable comeup I've had on any substance or combination. They do seem to compete a little bit for headspace though, moreso than MDMA and LSD did. Meh. Still fun haha. Bumped an additional 20mg 2C-D and 25mg MDMA about an hour and a half ago (T+2:30) after watching Tron: Legacy and that got me right back into the mix of things. :) The girl seems to be having fun. Listening to some DJ Tiesto and Pandora radio. All I want to do is keep talking but I don't want to turn this into one of Llama's ampheta-rants lol. Peace for now. Over to the Cuddle Puddle!
 
so 6apb is okay. will up the dose next time. i am a hard head.

when man first came out of the dream, did he make the dream reality, or did he make reality his dream?
 
Never Knows Best said:
realize that such a thing is accessible through many psychs, no need to praise this above others (as many have many other drugs before it, all to equal (in)validity, more or less).
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True that. For some reason every time I have a good trip, I tend to think that "this is best trip I've EVER had!". Then when I come down I realize that this may not necessarily be true. :D

And, regarding the potency thing, if you ever acquire the necessary funds, vendors are starting to sell the NBOMe phens on blotter paper. Making dosing accurately much less difficult. However, it's significantly less potent than intranasal, if I am to understand correctly.

thenightwatch said:
i had a 2C-I trip that told me that humans desire to reduce everything to a singularity
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Some humans do, anyway. Particularly psychedelically-inclined humans. Psychedelics have a prominent tendency to make people unify everything, particularly with their own identity. Unity of everything follows the pattern of science however, as our studies of the material world seem to point to ever more simplistic fundamental components of matter and energy. I just watched a lecture in which it was suggested that soon we will do away with the "strong force" and "weak force", and all forces will be reduced to manifestations of the force of gravity.

ray kurzweil, the futurist, makes a very good argument saying that every piece of matter in the universe will eventually be part of a self-aware super computer.
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Interesting. According to my demon-theory, it already is!
 
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TheAppleCore said:
True that. For some reason every time I have a good trip, I tend to think that "this is best trip I've EVER had!". Then when I come down I realize that this may not necessarily be true. :D

And, regarding the potency thing, if you ever acquire the necessary funds, vendors are starting to sell the NBOMe phens on blotter paper. Making dosing accurately much less difficult. However, it's significantly less potent than intranasal, if I am to understand correctly.



Some humans do, anyway. Particularly psychedelically-inclined humans. Psychedelics have a prominent tendency to make people unify everything, particularly with their own identity.



Interesting. According to my demon-theory, it already is!
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ideal right now seems to be HPBCD + 25I in an H20 solution.

this is a bummer: you can't use alcohol to make a vial that is complexed with HPBCD. the CCOH (Ethyl alcohol =p) will compete with the 25I for binding in the HPBCD. water doesn't compete for binding, its cool.

i wish some really smart person would figure out a preservative to add that would keep the solution safe from contaminants. problem is the same as with ethanol though.... the preservative might compete for binding.

maybe just salt would work. they used to use plain old sea salt/earth salt to preserve everything back in the day....
 
thenightwatch said:
ideal right now seems to be HPBCD + 25I in an H20 solution.

this is a bummer: you can't use alcohol to make a vial that is complexed with HPBCD. the CCOH (Ethyl alcohol =p) will compete with the 25I for binding in the HPBCD. water doesn't compete for binding, its cool.
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Interesting, hadn't heard that before. Well, the problem seems to be bypassed by simply using a salt, rather than complexed freebase. I made my solution with 20% ethanol, using 25I citrate. Is the complexed freebase any more potent than the salt?
 
thats a good question, and i'm not sure of the answer to it. we'll have to dig through the 25I and similar threads perhaps. i really want to figure out the best way to make 25I vials though.

using NaCl as a preservative in H2O+25I+HPBCD vials could also aid oral absorption.... i think your sublingual mucosa "open up" more in the presence of salt. not sure though, thats just a guess based on the way eating salt feels :)

also though if anyone wanted to evap your vial they'd end up with salt in the end product. that might not be a bad thing though, because then dumbasses that eyeball would end up consuming 25I thats actually like 90% salt =p

adding NaCl might convert the freebase to the HCl though. shit i should know whether or not it does lol. gotta get back in school, pretty much all my chemistry knowledge is from pihkal/tihkal, bluelight, google searches/wikipedia, and then chemistry 101 and half of 111 =p
 
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just read these edits so double post =p

TheAppleCore said:
I just watched a lecture in which it was suggested that soon we will do away with the "strong force" and "weak force", and all forces will be reduced to manifestations of the force of gravity.
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thats so fuckin cool lol :) makes perfect sense to me instantly after reading a bit about kurzeweil (who i understand is not the dude you're talking about, lol =p). it all has to do with consciousness right?

Interesting. According to my demon-theory, it already is!
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the wikipedia articles are literally all i've read about ray, but they do a very good job of explaining his ideas imo http://en.wikipedia.org/wiki/Ray_Kurzweil
 
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thenightwatch said:
the CCOH (Ethyl alcohol =p) will compete with the 25I for binding in the HPBCD. water doesn't compete for binding, its cool.
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Sorry, not much time: would some ionic preservative have better (lesser, that is) affinity to the CD? Benzoate or something like that? I believe a molecule like a 25XNBOMe as freebase should easily displace an organic, ionic preservative.
 
i think i read that HPBCD binding has more to do with the shape of the molecule than with the molecule's polarity. saw a pretty funny picture of a penis shaped molecule binding to an HPBCD ring once. the picture was meant to show that molecules need to be primarily long and straight to bind inside the ring of HPBCD.

ISOpropyl alcohol might be a good alternative for us. IPA might be crooked enough that it doesn't bind to the HPBCD ring. it would still dissolve the 25I just fine and it would keep our vials safe from contamination.... then the preservative question wouldn't need to be answered :)

i have been up all night and if i start up any serious research now i just won't sleep, so i'm gonna pass for the moment, but...

i'm sure there's at least one paper out there that will tell us if isopropanol binds to HPBCD.

if it does bind to HPBCD perhaps one of the other lower homologues of cyclodextrin would work better for us. the only reason everyone uses HPBCD specifically is because its name is famous due to its inclusion in frebreeze. other cyclodextrins might be better.

all cyclodextrins like HPBCD (short for hydroxy-propyl-beta-cyclodextrin) are really just fancy sugar molecules btw. HPBCD is just several sugar molecules connected in a ring shape :)

here's an example (from wikipedia lol =p) of how safe the stuff is

On July 14, 2010, Children's Hospital Oakland filed Investigational New Drug (INDs) applications with the FDA on behalf of the Hempel twins based on promising new animal data. Doctors requested to deliver hydroxy-propyl-beta-cyclodextrin intrathecally and directly into the central nervous system of the twins in an attempt to arrest neurodegeneration and deliver the compound across the blood-brain barrier. The INDs were approved on September 23, 2010, and bi-monthly intrathecal injections of HPbCD into the spine were administered starting in October 2010. Additional filings have been made to the FDA by Children's Hospital Research Center Oakland requesting approval to surgically implant Medtronic SynchroMed pumps into the twins to deliver continuous doses of HPbCD into their brains.
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If I remember correctly there's just place for one water molecule in straight alpha-CD, so maybe smaller CDs than straigt beta-CD aren't that useful for relatively bulky compounds such as 25X-NBOMe derivatives.
The shape of the molecule is important for sure but since the inside volume of Cyclodextrins is relatively hydrophobic, I imagined that a ionized compound is easily replaced with a nonpolar compound.
I would guess that Cyclodextrins wouldn't work that great with pure isopropanol as solvent because it certainly fits into them and is less polar than water, so the equilibrium may be worse than in 20% EtOH/water.
The best idea would be to try various (derivatized) CDs in various solvent mixtures to find the ideal composition. Any volunteers? :D
 
Well, it may belongs to the ADD forums. But to add something more on-topic, I stumbled over this and totally love the noises appearing after 2 minutes. Sounds like transdimensional electric birds talking in outer-worldly languages. Very trippy that kind of psy trance and doesn't get boring :)
 
^^^^ what data would we collect from the testees? psychedelics are so hit and miss sometimes based on many other factors, our studies would have to be extensive....... LOTS of trials to compensate for how random psychs can be XD
 
All this talk about 25I recently makes me very excited to try mine (and the 25C and 25D). Gotta let last night's revelry integrate first though. It was a great night. I have the same reaction as TAC a lot of the time it seems; last night for a while I was like "This is the best, this is better than candy-flipping!" But after the initial hour or so rush I decided it was just good. Lol.

Working on processing some m. hostilis to make...soap, but my solvent layer appears to have picked up some of the powdered bark. Never had this problem before. Frustrating. I think it's just taking forever to separate.
 
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