cosmotroniks
Greenlighter
Phencyclidine was originally developed and used, from 1957 through 1965, in a clinical (i.e. hospital) setting as a surgical anesthetic for humans.
Parke-Davis and Co. (the original manufacturer of the drug, based out of Detroit, MI) voluntarily withdrew the drug from the market and requested that all clinical trials be stopped due to the adverse "emergence effects".. For example, people would come out of the dissociative anesthesia and be in altered states of consciousness lasting from around four to eight hours at the short end, all the way up to nearly a month in some rare cases. Delusional thought patterns, mania, paranoia, agitation, diminished ability to articulate and/or process abstract thoughts, psychosis, and schizophrenia like effects were all encountered.
However, the anesthetic doses of PCP that were used in supervised medical conditions ranged from 25-40 mg on average, with 50-60 mg being the "top end".. this is WAY more than the average street user will ever consume in a typical single session... I've done it myself (smoked 'supergrass' - marijuana sprayed/treated with liquid PCP HCl soln in white gasoline... you probably already knew that) and had far too much. I went past the "ozone" as it's been described, and into the "overdosed" state where total loss of conscious reality occurs. Actual loss of waking consciousness does not happen, at least not at the dosages I've taken; my best estimate is that the highest amount I've ever taken in one whack was about 50 mg.. way too much. Don't do that high an amount, even if you think you have a "tolerance". It's just too strong. Plus, you waste a good trip, since it effectively "knocks you out" completely.
Do more than 70 or 80 mg and you'll have a super fun experience that can include a Grand Mal seizure, myoclonic seizure, convulsions, a hypertensive stroke (but hey, at least you've got the good 'ol neuroprotective effects of a powerful NMDA open channel blocker on your side), or even a thrilling heart attack.. (sorry about the sarcasm there). Dosages from 100-200 mg have been proven fatal in most cases. At the very least, most who consume such a quantity end up in a coma.
So be extremely careful with PCP if you are using it or plan to try it. It's probably the strongest psychoactive in existence overall. Other drugs may have distinctly profound effects in other areas, but there's nothing quite like being high on the HOG. I've been there many, many times. It's super fun, at least for me. A real way to "get your kicks".. but some cannot tolerate or handle the effects of dissociatives very well. I love them, personally. They are my drug category of choice.
Especially PCP: my number one chemical of choice. A guaranteed blast into outer space - or hell, depending on how one handles and/or likes/dislikes the subjective effects.
I would venture to say that most of the potentially damaging effects from chronic PCP use stem from two main factors:
1. NMDA receptor downregulation, causing cognitive deficits lasting from months to years, but eventually returning to normal.
2. Permanent damage/alteration resulting from exposure to improperly manufactured PCP that was made from the nitrile intermediate and displaced with an aryl grignard - I'm talking about the immediate nitrile precursor, 1-piperidinocyclohexanecarbonitrile, or PCC for short. This is an extremely potent neurotoxin that has been proven by professional pharmacological toxicologists to cause a permanent aggravated psychotic condition with a severe "allergy" to the chemical with chronic administration..
These two references cover the matter fairly well:
http://www.erowid.org/archive/rhodium/chemistry/pcp.shulgin.html
http://www.erowid.org/archive/rhodium/chemistry/pcp.pcc.analysis.html
additional info is also available here:
http://www.erowid.org/archive/rhodium/chemistry/pcp/pcp_index.html
and also here:
http://www.erowid.org/chemicals/pcp/pcp.shtml
and these here:
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2965
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2054
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2920
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2966
and this is basically everything they've got:
http://www.erowid.org/references/refs.php?S=pcp+or+phencyclidine
PCP definitely demonstrates a positive anticholinergic effect, specifically at the NACHr (nicotinic acetylcholine receptor). Don't know about the muscarinic acetylcholine receptors, but nicotinic would be consistent with what this particular thread is concerned with.
But as I said before, most damage from PCP would probably be encountered through downregulation of epsilon and zeta NMDA receptors (primarily epsilon if I'm not mistaken - TCP is much more specific for zeta NMDA subtype receptors)... such downregulatory neural alterations would result in potentially significant, although probably not permanent, deficits in thinking and memory, as well as speech and positional/spatial awareness and movement-coordination functions; alternatively, the more permanent adverse effects, characterized by an aggravated psychotic state or schizophrenic-like state are more than likely brought about by PCC and not PCP.
The so-called 'bucket method' (won't go into specific details, since this is of course a harm-reduction and learning/discussion forum and NOT a synth forum) %) is what really scares me the most for potentially ending up with unresolved/unconverted PCC in the final product - since they're using friggin' 55-gallon drums and crap like that to manufacture these massive quantities of liquid PCP, how in the ever living f*** are they supposed to know whether it's pure or not? The simple answer: they don't.
If you must insist on using PCP as much as I used to (just about every day) then you need to be very careful about mainly two factors:
A. your source - is it good purity and quality, and is it really genuine PCP?
B. overall dosage/quantity - this is actually the easiest to manage, at least in my experience, by smoking. Two or three good hits of PCP-treated weed will have you trippin' balls like you wouldn't believe, guaranteed.. no need to take more. Just wait about three to five minutes, then you'll really feel it good..
the high will take care of itself, and usually peaks in about 15-20 minutes if smoked. It's an absolute blast, IMHO. I love PCP, and always will.
dosages are roughly as follows (and I claim no responsibility/shall not be held liable if bad things happen; do your own research as well):
A light, "buzzed" state shall result from the ingestion of 1-3 mg.
Further dissociation, the second "plateau" of PCP, colloquially known as being "wasted", is found at about 5-10 mg.
Pushing on past 10 mg leads one on to the "ozone layer" with heavy dissociation and tranquilized sedation, my personal favorite.
Anything over 20-25 mg is pushing up into the "overdosed" state in which you lose all contact with normal reality, a "Dust-hole" as it were..
Dosages over 60-70 mg are extremely dangerous and may result in physical adverse effects including hypertensive CVAs and seizures or cardiac arrest.
Anything beyond 100 mg is just asking to die... don't go there.
Parke-Davis and Co. (the original manufacturer of the drug, based out of Detroit, MI) voluntarily withdrew the drug from the market and requested that all clinical trials be stopped due to the adverse "emergence effects".. For example, people would come out of the dissociative anesthesia and be in altered states of consciousness lasting from around four to eight hours at the short end, all the way up to nearly a month in some rare cases. Delusional thought patterns, mania, paranoia, agitation, diminished ability to articulate and/or process abstract thoughts, psychosis, and schizophrenia like effects were all encountered.
However, the anesthetic doses of PCP that were used in supervised medical conditions ranged from 25-40 mg on average, with 50-60 mg being the "top end".. this is WAY more than the average street user will ever consume in a typical single session... I've done it myself (smoked 'supergrass' - marijuana sprayed/treated with liquid PCP HCl soln in white gasoline... you probably already knew that) and had far too much. I went past the "ozone" as it's been described, and into the "overdosed" state where total loss of conscious reality occurs. Actual loss of waking consciousness does not happen, at least not at the dosages I've taken; my best estimate is that the highest amount I've ever taken in one whack was about 50 mg.. way too much. Don't do that high an amount, even if you think you have a "tolerance". It's just too strong. Plus, you waste a good trip, since it effectively "knocks you out" completely.
Do more than 70 or 80 mg and you'll have a super fun experience that can include a Grand Mal seizure, myoclonic seizure, convulsions, a hypertensive stroke (but hey, at least you've got the good 'ol neuroprotective effects of a powerful NMDA open channel blocker on your side), or even a thrilling heart attack.. (sorry about the sarcasm there). Dosages from 100-200 mg have been proven fatal in most cases. At the very least, most who consume such a quantity end up in a coma.
So be extremely careful with PCP if you are using it or plan to try it. It's probably the strongest psychoactive in existence overall. Other drugs may have distinctly profound effects in other areas, but there's nothing quite like being high on the HOG. I've been there many, many times. It's super fun, at least for me. A real way to "get your kicks".. but some cannot tolerate or handle the effects of dissociatives very well. I love them, personally. They are my drug category of choice.
Especially PCP: my number one chemical of choice. A guaranteed blast into outer space - or hell, depending on how one handles and/or likes/dislikes the subjective effects.
I would venture to say that most of the potentially damaging effects from chronic PCP use stem from two main factors:
1. NMDA receptor downregulation, causing cognitive deficits lasting from months to years, but eventually returning to normal.
2. Permanent damage/alteration resulting from exposure to improperly manufactured PCP that was made from the nitrile intermediate and displaced with an aryl grignard - I'm talking about the immediate nitrile precursor, 1-piperidinocyclohexanecarbonitrile, or PCC for short. This is an extremely potent neurotoxin that has been proven by professional pharmacological toxicologists to cause a permanent aggravated psychotic condition with a severe "allergy" to the chemical with chronic administration..
These two references cover the matter fairly well:
http://www.erowid.org/archive/rhodium/chemistry/pcp.shulgin.html
http://www.erowid.org/archive/rhodium/chemistry/pcp.pcc.analysis.html
additional info is also available here:
http://www.erowid.org/archive/rhodium/chemistry/pcp/pcp_index.html
and also here:
http://www.erowid.org/chemicals/pcp/pcp.shtml
and these here:
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2965
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2054
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2920
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=2966
and this is basically everything they've got:
http://www.erowid.org/references/refs.php?S=pcp+or+phencyclidine
PCP definitely demonstrates a positive anticholinergic effect, specifically at the NACHr (nicotinic acetylcholine receptor). Don't know about the muscarinic acetylcholine receptors, but nicotinic would be consistent with what this particular thread is concerned with.
But as I said before, most damage from PCP would probably be encountered through downregulation of epsilon and zeta NMDA receptors (primarily epsilon if I'm not mistaken - TCP is much more specific for zeta NMDA subtype receptors)... such downregulatory neural alterations would result in potentially significant, although probably not permanent, deficits in thinking and memory, as well as speech and positional/spatial awareness and movement-coordination functions; alternatively, the more permanent adverse effects, characterized by an aggravated psychotic state or schizophrenic-like state are more than likely brought about by PCC and not PCP.
The so-called 'bucket method' (won't go into specific details, since this is of course a harm-reduction and learning/discussion forum and NOT a synth forum) %) is what really scares me the most for potentially ending up with unresolved/unconverted PCC in the final product - since they're using friggin' 55-gallon drums and crap like that to manufacture these massive quantities of liquid PCP, how in the ever living f*** are they supposed to know whether it's pure or not? The simple answer: they don't.
If you must insist on using PCP as much as I used to (just about every day) then you need to be very careful about mainly two factors:
A. your source - is it good purity and quality, and is it really genuine PCP?
B. overall dosage/quantity - this is actually the easiest to manage, at least in my experience, by smoking. Two or three good hits of PCP-treated weed will have you trippin' balls like you wouldn't believe, guaranteed.. no need to take more. Just wait about three to five minutes, then you'll really feel it good..
the high will take care of itself, and usually peaks in about 15-20 minutes if smoked. It's an absolute blast, IMHO. I love PCP, and always will.
dosages are roughly as follows (and I claim no responsibility/shall not be held liable if bad things happen; do your own research as well):
A light, "buzzed" state shall result from the ingestion of 1-3 mg.
Further dissociation, the second "plateau" of PCP, colloquially known as being "wasted", is found at about 5-10 mg.
Pushing on past 10 mg leads one on to the "ozone layer" with heavy dissociation and tranquilized sedation, my personal favorite.
Anything over 20-25 mg is pushing up into the "overdosed" state in which you lose all contact with normal reality, a "Dust-hole" as it were..
Dosages over 60-70 mg are extremely dangerous and may result in physical adverse effects including hypertensive CVAs and seizures or cardiac arrest.
Anything beyond 100 mg is just asking to die... don't go there.
