Ekscentra
Bluelighter
- Joined
- Feb 20, 2014
- Messages
- 53
After attempting to post this in the nootropics thread, I decided I may get a better answer here, and I'd prefer not to derail a thread with a topic only partially relating to nootropics (and indirectly, at that.) I've noticed something strange with regard to stimulants, something I haven't seen mentioned anywhere at this point. Some act as sedatives for me (while paradoxically preventing sleep) while others act as stimulants while still having the sensation of being sedated (though not actually being sedated, just the physical sensations in my head around the same areas I've noticed in stimulants that cause sedation.) Nicotine, for example, sedates the hell out of me. The more I've used it, the stronger all of the effects have gotten, a strange sort of reverse tolerance. At this point, I can no longer use the patches at any dose as it's so sedating I can't function when I'm on them (unfortunate, as Nicotine has been the most reliable daily cognitive enhancer, in my experience.) Caffeine does exactly the same thing - I'm extremely tired, yet unable to sleep. Amphetamines and methylphenidate (shit drug, by the way), despite my paradoxical reactions to nearly every other stimulant, manage to keep me awake while, as I said, giving me the physical sensation I associate with sedation. PRL 8-53 is the only stimulating substance that lacks this physical sensation of sedation, though it doesn't feel like a traditional stimulant at all, otherwise I wouldn't need D-Amphetamine in the first place (that and the quick building of tolerance with frequent use, restricting my use to twice a week.) Any possible pharmacological reason for this? I originally thought it might be due to the extended-release mechanism the patches, but this wouldn't fit with the fact that caffeine still acts as a sedative for me. Sedation from both nicotine and caffeine have been present at all doses attempted (1mg to 15mg and 60mg to 1g, respectively.)
Another note, for what it's worth. I have Asperger's and ADD, two "disorders" (hardly a proper term for what is nothing more than a different way of thinking, but I digress) that significantly increase the chances of a paradoxical reaction. While my ADD may explain my reaction to both caffeine and nicotine, and perhaps even amphetamine, I'm not interested in seeing either of these two as reasons for the cause. I'm asking a very specific question regarding pharmacology. With all due respect to anyone reading this thread, if I wanted either of these conditions as answers to my problem, I wouldn't have posted this thread in the first place. I'm looking for a specific answer, not a vague blanket statement. Paradoxical reactions still aren't well understood by the medical community, so feel free to speculate here. This exact issue may or may not have been mentioned before - I haven't seen anything of the sort, otherwise I'd have been posting in a currently-existing thread rather than creating a new one. Any replies are much appreciated.
TL;DR: What might explain paradoxical reactions to most stimulants, yet normal reactions to amphetamines, especially in users with ADD/ADHD and Asperger's?
Another note, for what it's worth. I have Asperger's and ADD, two "disorders" (hardly a proper term for what is nothing more than a different way of thinking, but I digress) that significantly increase the chances of a paradoxical reaction. While my ADD may explain my reaction to both caffeine and nicotine, and perhaps even amphetamine, I'm not interested in seeing either of these two as reasons for the cause. I'm asking a very specific question regarding pharmacology. With all due respect to anyone reading this thread, if I wanted either of these conditions as answers to my problem, I wouldn't have posted this thread in the first place. I'm looking for a specific answer, not a vague blanket statement. Paradoxical reactions still aren't well understood by the medical community, so feel free to speculate here. This exact issue may or may not have been mentioned before - I haven't seen anything of the sort, otherwise I'd have been posting in a currently-existing thread rather than creating a new one. Any replies are much appreciated.
TL;DR: What might explain paradoxical reactions to most stimulants, yet normal reactions to amphetamines, especially in users with ADD/ADHD and Asperger's?
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