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  • AADD Moderators: Tronica

Panadeine and Paracetamol - Potential Liver Damage

would be good to see paracetamol come with warnings on the packets.

we get a lot of paracetamol od's and if they cant get to the liver in time to flush it out, think its about 4 hours post ingestion, than its a rather slow death, so people who intentionally od have time to think about their often irreversible condition.

we had one young kid, 19 i think, that was taking paracetamol and codeine to help him sleep at night, after about 6 months he develop liver failure and died before he could get a transplant.

I can personally recommend milk thistle and omega 3s for tidying up my liver. I had abnormal ALT,AST,LDH and often billirubin, took these supplements and reduced alcohol intake and now my liver is tip top.

1/3 of my circulating red blood cells were what are called stomatocytes, which is evidence of liver damage, namely due to alcohol and fatty liver. These days a stomatocyte is nowhere to be seen.

If you have a few extra kilos around your waistline/gut area, dropping that quickly will also show a big improvement in liver function.

Its a good thing that hepatocytes are such tough little bugger and can regrow ( u can remove say 1/3 of your liver and over time it will grow back ).

thought the frothy pee was more of a sign that your kidneys are not coping with the excess protein.
 
^ The 4h thing is about using activated charcoal to reduce absorption of the paracetamol (or other drugs) from the gut. They can still benefit from using NAC to reduce the oxidate liver damage if it's started within 24h, but you're right that they can potentially die a slow painful death despite medical help.

If that kid was just taking paracetamol once a day he must have been taking a huge amount to get liver damage, or have had other factors (alcohol, underlying liver disease, etc.). A 19y.o. male should be able to handle an adult dose easily.

You're right, frothy urine is usually from kidney damage causing leakage of protein into the urine. Liver damage would cause a decrease in protein as the liver produces most plasma proteins.

I'm pretty sure a healthy person can regenerate their liver even if you remove even 2/3 - 3/4 of it. Also you need to lose 80-90% of your liver's functional capacity before you actually get liver failure. Remarkable organ ;)
 
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