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  • BDD Moderators: Keif’ Richards | negrogesic

Pagoclone an GABA partial agonist

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Bluelighter
Joined
Oct 29, 2012
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Studying research chemicals
So I found this stuff called Pagoclone which is a Partial agonist of GABAa receptor... What can I expect from it ? Is it milder then Benzodiazepine, is it different then its cousin Zopiclone ? Those are positive allosteric modulator of GABAa so im not really sure if the effect would be similar.

Any experience or comment on this would be appreciated, Thanks !
 
Wiki says that its more closely related to the z-class drugs and has anxiolytic effects without the hypnotic or sedative effects of benzo'z or z-class drugs. Im going to take a guess and say that the lacking in sedative effects is probably dose dependant, I believe that full agonists like ludes keep gaba receptors open and provide constant release while allosteric modulators open the receptors open for longer but not constantly releasing.
 
Apparently this is good for stuttering. Which would be great as I tend to get that crap when speaking to strangers, people I know find it strange since it never happens otherwise. Flurazepam is also a partial BZD-agonist, but acts much differently (one hell of a sedative). I could get 100mg on the cheap, doses for humans are stated to be 2-4mg, so I guess if it was commercialized it would have 2 and 4mg pills...of course taking 10mg at once could cause a more typical benzo-ish experience. But I'm tempted to get some if only for the times I have to go out and not lose the stuttering only by getting drunk and high (just weed) or taking Dexedrine. My only issue is that it is a z-drug, not in the same class as the 3 ones that are considered pharmaceuticals, so eh, I might give this a whirl to try a new vendor in my own country, which is good, paying in foreign currency is really bad for Canadians all of a sudden, it's almost as bad as it was in the 90's since this summer where it decided to stop dropping at 0,75 for the US. It's now 1:2 (and even a little more when it comes to GBP's..1 gbp = 2,02, in january it was 1gbp = 1,58 cad...one hell of a drop.

Anyway, I'll update this as soon as I give it a try, no need for an allergy test if I react awesomely to Zaleplon already (and meh to zopiclone and zolpidem), but I'll first take 2mg and see, I wish it doesn't taste like complete ass like other z-drugs though (although, zaleplon powder inside the caps was very tasteless and made it easy to snort...it's not commercialized anymore but a compounding pharmacy is saying that if I get a script they'll make me some...in January 2016, it was the best sleep medicine for me and it was taken away, probably because too many people enjoyed to snort it, it was a really thin small line one would get out of a 3mg/6mg cap. It was expensive as hell though when it could be obtained as Starnoc, not at the Sublinox (our sublingual zolpidem 10mg tabs up here...that shit ain't covered by gov insurance and my friend with his fancy union insurance doesn't get it covered either when he was scripted 30 of 'em). All things considered, I'm having one hell of a good deal.

It's a partial BZD GABA subcomplex ligand, not just a partial-GABA(A/B) agonist. Acts mostly on α2/α3, hypnotics hit α1 heavily, typically, along with the y1/y2 sites.
 
Well, it was useful as I had to wait after my psy doc who was dragging his feet renewing my valium script. There's no reason to see him so the pharmacy just sends him a fax for a renewal demand. He waited fucking 2 weeks.

The fact the powder is pink makes me wonder, is it naturally pink or they colour it that way with food colouring. In my experience all drugs except pcp are white powders when pure, pure pcp is yellow, at least in liquid form (with alcohol added), never saw pure powder pcp, although I think, it is also white. Most people use it as powder here, to snort or eat but the thing is, it's the liquid thrown on some inert material which is then crushed, and that is cut heavily with lactose to have safe handling by most people who do not have microgram scales.

Anyway, it did the job, but the length of action is pretty short. Next time I'm just going to get etizolam powder when I order something to help when life is being a bitch and I feel like I need more valium. I wouldn't recommend it. It's not euphoric and it has zero muscle relaxant effects, which is one of the main reason I take valium, it helps with TMJ disorder pain a hell lot.
 
It seems like it's on the market again, at least in Europe. Has anyone experience with Pagoclone? I'd love to try it, but I'm unsure if I should try it, as it's rather pricey. On the other hand I would like to have an anxiolytic, scince I'm unable to use benzos due to drug tests
 
Try valerian root that isn't as addictive and is quite good for sedating and having a calming effect. Benzos are on the other hand a road to hell with addiction and dependence with worse withdrawals than what the drug was used for in the first place. I'm on zopiclone which leaves my mouth with that horrible taste, just read up about pagoclone and wiki seems to be saying it's going to be tried as an alcohol substitute sounds promising if it gets marketed, alcohol is way worse on the body and mind than what pagoclone could do. Basically a watered down version of alcohol without that shit hangover the next day.
 
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I believe Robotrippin did a trip report at one point.

Edit: https://www.bluelight.org/xf/thread...perienced-the-perfect-drug-for-trauma.825351/

The z-drugs are certainly interesting compounds. Maybe a little unpredictable, but certainly a lot of potential. I find there to be a very creative side to zopiclone and zolpidem.

There was a website at one point where people could post their ambien art.

Zopiclone would have me sitting up at night writing and making music on cubase (which is odd seeing as I had no fucking clue how to use it otherwise).

People like to rearrange their furniture on ambien too apparently.

I read that a number of the potential derivatives of the z-drugs ended up being toxic or having some flaw which prevented them from being marketed unfortunately.

I think that's why I'm erring on the side of caution with this one.
 
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It's pretty crappy, I had a few grams of the stuff and ended up tossing the last 300mg, doesn't feel good, makes one sleepy, but that's about it. Z-drugs are the most cancerous drugs out there, don't bother with that stuff peep. Yes, the powder is pale pink, it's normal.
 
I found that taking the z drugs like Imovane and Ambien 10yrs later with a solid benzo tolerance, their effects in terms of visuals completely subside to the point there are none.
 
I came across pagoclone article that said this

"Pagoclone is a novel, non-benzodiazepine, GABA-A selective receptor modulator. It is part of a new chemical class of agents and lacks many of the common benzodiazepine side effects such as sedation and withdrawal. Pagoclone trials have enrolled over 1,600 patients to date. The precise mechanism of action is unknown, however, GABA is believed to be an important neurotransmitter in the brain that may be disrupted in people who stutter. Pagoclone enhances the activity in GABA circuits in the brain and thus may help restore more normal function in speech areas of the brain. In early 2005, Indevus was granted a U.S. patent directed towards the use of pagoclone for the treatment of stuttering."

Stating it doesn't have withdrawal unlike benzodiazepines doesn't make any sense lol? In link below it was in phase III trials in 2007. Its been long enough that more info should be available.


www.stutteringhelp.org

Pagoclone and Clinical Trials

LEXINGTON, Mass. (Sept. 26, 2006) - Indevus Pharmaceuticals, Inc. (NASDAQ: IDEV) today announced that following an End of Phase II meeting with the FDA, the Company has established a clinical plan towards regulatory approval of pagoclone for the treatment of persistent developmental stuttering...
www.stutteringhelp.org www.stutteringhelp.org


@THE_REAL_OBLIVION Are currently prescribed F.D.A. approved Z-drugs cancerous or only the ones that weren't marketed?
 
AFAIK all the benzpdiazepines are positive alllosteric of GABA, so it's nothing new.

Pagolone IS a rather weak and useless compund but it's got an interesting history behind it. Se. Mutta (The inbentory) was so amazed by it that he saw huge potentiel behind it to made an alcohol mimicking beverage, with virtually all The benedits and none of it's downsises. A lot Time has passed since and nothing worth mentioning has not happened so personally i wouldn't hold My breath.
 
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