P. Harmala and 2C-P

[!!4iV4HF9R34g]

I've been trying to find any reports or effect profiles of 2C-P in combination with an MAOI, like Harmaline.

 

[sekio]

Bad idea, 2c-P is an intense trip on its own.

 

[Incunabula]

He he, Yeah, That does sound like an exceedingly bad idea. And what´s the point? Want to save some material or what? it´s plenty potent

 

[!!4iV4HF9R34g]

I've been dosing 2C-P since I acquired it.
I love the intensity, and I already conserve by vaporizing the compound haha.

I just like to experiment, and I've got a ton of Peganum Harmala lying around.
Plus, it could be very nice to keep the onset time of vaporized 2C-P with the duration of oral delivery.

 

[clubberdude]

Might be somewhat overwhelming. 2C-P is powerful enough on its own. I didn't find 2C-P to be that stressful from a cardiovascular standpoint, but not sure whether an MAOI would be that safe on it.

 

[!!4iV4HF9R34g]

Yeah, I actually have only ever experienced any sort of bodyload once from 2C-P, and it was only from the initial shock of the first time I vaporized it.
THAT was quick haha.

I will get back here with some information on it eventually I suppose.

 

[any major dude]

AFAIK that's really unexplored territory. I'd advise against it, but if you do decide to do this, slowly titrate your dose up over several experiences, definitely don't go balls deep on round one. Some type of standardized extract would also probably be advantageous for this purpose as well, that way you could be very precise with your dosages.

 

[!!4iV4HF9R34g]

Of course, I've performed many extractions with the P. Harmala.
I plan on threshold doses for MAOI effects in combo with what is, for me, a normal dose of 2C-P.

Actually though, I find it pretty cool venturing into unknown waters.
Not very often that I get to actually research something without a predisposition from the web.

 

[any major dude]

sounds like you know what you're doing. P. Harmala seems to be active on its own, so there are probably some additional active substances aside from the harmala alkaloids present, and that may skew your results a bit. And just to be safe, i'd probably start with a lowish dose of 2c-p as opposed to a normal one. 5-7mg would probably be the max i'd start with. Good luck & do tell how that goes. I do know of some people making "cactushuasca" so PEA's & harmalas have been used safely to some extent, though i haven't heard very much on 2c-x's with MAOIs at all.

 

[!!4iV4HF9R34g]

I'll likely vaporize about 1.5-2mg, then possibly dose again as I peak. I prefer vapor because you can gauge the experience to an extent due to it's fast onset, while maintaining the intensity of an orally-activated experience, and also shortening the duration to approximately six hours.

I would be interested to know if any of the following alkaloids have known adverse reactions with PEAs like 2C-P: harmine, harmaline, harmalol, peganine, tetrahydroharmine, telepathine, banisterine, beta-Carboline, serotonine, vasicine, vasicinon and desoxy vasicinon.

Thank you for your help.

 

[freedstar]

I'll likely vaporize about 1.5-2mg, then possibly dose again as I peak. I prefer vapor because you can gauge the experience to an extent due to it's fast onset, while maintaining the intensity of an orally-activated experience, and also shortening the duration to approximately six hours.

I would be interested to know if any of the following alkaloids have known adverse reactions with PEAs like 2C-P: harmine, harmaline, harmalol, peganine, tetrahydroharmine, telepathine, banisterine, beta-Carboline, serotonine, vasicine, vasicinon and desoxy vasicinon.

Thank you for your help.

Whats your tolerance like? Should always be a good idea mentioning in case anyone in the future reads this and gets ideas.

 

[TheAppleCore]

Interesting idea. Do phenethylamines usually combine safely with RIMAs? This would be the first question to ask.

 

[!!4iV4HF9R34g]

Good call; my tolerance is minimal, I've dosed 2C-P twelve times now, ranging from 2mg-8mg smoked, and 12mg orally.
This has been over the course of three months, excepting the initial try, which was approximately four months before my first order.

RIMAs have a tendency to react negatively in conjunction with stimulants.. Considering 2C-P is a PEA, I would not know how safe this would be.

Additionally, I have no RIMAs, only Syrian Rue.

 

[greenmeanies]

....

Harmaline is considered a RIMA (reversible inhibitor of monoamine oxidase A type) because it inhibits the MAO-A enzyme-- you guessed it-- temporarily.

Certain clinical MAOIs like phenelzine are non-reversible, meaning they bind permanently to the body's MAO enzyme supply.

 

[!!4iV4HF9R34g]

Hahahahahaha. I feel dumb.
But yeah, you're right.

Strange how a simple changing of phrase can yield new information.
Research into general MAOI interactions with PEA led nowehere, but some quick study with RIMA in lieu led to a stimulant warning.

Still, PEAs are not direct stimulants.. Is the PEA effect profile similar enough to that of basic stimulants to warrant the warning of combination?

 

[TheAppleCore]

^ I suggest making a post in Advanced Drug Discussion. You might get some more in-depth feedback there.

 

[greenmeanies]

I would venture a guess that YES, the standard "PEA effects profile" of most 2c-x lends them to probably negative reactions when combined with a RIMA.

That is to say, 2c-x usually causes strange fluctuation in blood pressure. This is probably exacerbated by harmala.

2c-x usually causes strange fluctuation in (perceived) body temperature. Probably exacerbated by harmala.

2c-x usually causes nausea. Probably exacerbated by harmala.

It is not thoroughly understood, but possible that certain 2c-x are not just 5ht agonists but may also interact with the serotonin transport system (like MDMA) which is a BIG no-no to combine with any MAOI. Extra levels of serotonin, combined with inability to catabolize it? Problems ensue.

 

[TestOfSanity]

That is to say, 2c-x usually causes strange fluctuation in blood pressure.

I don't agree with this. I'm pretty cautious about my blood pressure, every time I tried a new 2c, I monitored pulse and blood pressure. The results are all fairly the same. A definite rise in pulse and blood pressure, that usually peaks 1-2 hours after ingestion (peak of the drug). After that it goes back to normal, and weirdly with 2c-p it goes down. This may be because it thins the blood (as I've read). So yes it does cause a fluctuation in pulse/bp, but that has to be expected with most drugs. But, everyone is different and will be affected different.

 

[!!4iV4HF9R34g]

While I haven't monitored my vitals during an experiment (I ought to start), I have not seemed to notice any of the aforementioned effects.
I sometimes feel a bit colder than normal, but this is pleasant.
Nausea is also not a problem; but if I could get any tips for reduction of any potential nausea, that would be nice.

Serotonin Syndrome is all I would worry about myself.

 

[immad]

I don't agree with this. I'm pretty cautious about my blood pressure, every time I tried a new 2c, I monitored pulse and blood pressure. The results are all fairly the same. A definite rise in pulse and blood pressure, that usually peaks 1-2 hours after ingestion (peak of the drug). After that it goes back to normal, and weirdly with 2c-p it goes down. This may be because it thins the blood (as I've read). So yes it does cause a fluctuation in pulse/bp, but that has to be expected with most drugs. But, everyone is different and will be affected different.

Do you have any scientific papers to back up the thins the blood statement? I'd like to read more about it.