Oxytocin

[Godzilla]

Has anyone had any experience with taking say 20 + or - units of oxytocin putting it in sodium chloride solution and inhaleing it like a nasal spray???? Any noticeable effects???

 

[Eshu2012]

There is an available form that is a sublingual gell, however, so far the substance seems worthless....ie it seems to be hype....

 

[any major dude]

intranasal oxytocin does induce some changes regarding feelings toward ingroups & outgroups that have been measured in a few psychology studies, however it did not appear to alter consciousness in a psychedelic or empathogen like fashion.

 

[telepathetic]

i'd like to hear more about that, any major dude, do you have a link?

 

[Godzilla]

Ive also read that it can elevate mood, sexual feelings, sense of,well being, its a hypothesis that oxytocin may play,a role in the euphoria felt from mdma, along with the flood of serotonin and decreased uptake,of serotonin.
I just need the doseage, I guess I can allways start low and work my,way up of course this is only to benefit science

 

[<<ellisd>>]

^Yeah I had a thought about supplementing Methylone with Oxytocin to see if it added any thing to the effects. I might research that someday.

 

[CheapHighMan]

If you do it tell us what it's like

 

[PsychedelicPeptide]

The problem with oxytocin is that it has a number of actions in the CNS, including diuresis (makes you stop peeing). So while there may be some mildly interesting effects like improved facial pattern recognition or even bonding if you are in the right setting, the diuresis really stands out and keeps you from using too much less you not pee for many hours. This can be particularly problematic when combining it with other drugs that may also lessen one's ability to urinate.

The real question to consider is that when the brain releases oxytocin, say in response to another drug like MDMA or the presence of your significant other, it probably does not flood all of the CNS and periphery with oxytocin to stimulate all possible oxytocin receptors in the body, rather it releases it to a specific set of neurons to get the desired effect (ie, bonding).

But when you do something like intranasal oxytocin where you take a huge dose just to get a "decent" amount into the brain, and a bunch of that initial dose just ends up falling down your nasal pathways into your periphery, you end up activating all of the oxytocin receptors in the body and brain and you get all of the effects... both those desirable and undesirable.

So just my 2 cents, if you can get good product and have the time and money to mess with it it can be interesting when used in the proper setting, and even with other drugs, but do not be let down if all you get is disappointment. I made some posts on this forum a few years ago about my own oxytocin use, you may try to look them up. I also find it made me tired.

Also regarding dose, just start spraying it up there man. Use a lot, oxytocin was not made for intranasal dosing. Then you just have to get yourself into a situation where you will notice the effects.

 

[Alexander Gray]

I would just like to point out that oxytocin doesnt cross the blood brain barrier at all. So orally, nasally, rectally, intravenously, intramuscularly, buccally and sublingually are all effectively worthless

Oxytocin is destroyed in the gastrointestinal tract, and therefore must be administered by injection or as nasal spray. Oxytocin has a half-life of typically about three minutes in the blood. Oxytocin given intravenously does not enter the brain in significant quantities - it is excluded from the brain by the blood-brain barrier. There is no evidence for significant central nervous system entry of oxytocin by nasal spray. Oxytocin nasal sprays have been used to stimulate breastfeeding but the efficacy of this approach is doubtful.[56]

So did nobody bother to read the wikipedia article at all?

 

[CheapHighMan]

I would just like to point out that oxytocin doesnt cross the blood brain barrier at all. So orally, nasally, rectally, intravenously, intramuscularly, buccally and sublingually are all effectively worthless



So did nobody bother to read the wikipedia article at all?

wooowww... I never thought to do that and that's what I usually do first.

Thank you very much

 

[avcpl]

I would just like to point out that oxytocin doesnt cross the blood brain barrier at all. So orally, nasally, rectally, intravenously, intramuscularly, buccally and sublingually are all effectively worthless

So did nobody bother to read the wikipedia article at all?

These studies and others don't seem to think it's worthless...

Vol 435|2 June 2005|doi:10.1038/nature0370
Oxytocin increases trust in humans
http://www-psych.stanford.edu/~knutson/bad/kosfeld05.pdf
. Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation
in non-human mammals 6–8, causes a substantial increase in trust
among humans, thereby greatly increasing the benefits from social
interactions.

The Journal of Neuroscience, January 7, 2009 • 29(1):38 – 42
http://www.jneurosci.org/content/29/1/38.full.pdf
" Our data indicate that a single dose of intranasally administered oxytocin 40 min before encoding causes a substantial improvement in the
ability to recognize faces a day later, while leaving entirely unaffected the recognition of nonsocial stimuli."

 

[Godzilla]

I took one for the BL team. I took 20 u in 2 ml inhaled. I was kinda scared but did not notice anything for about 10 min when I stated to feel a small sense of energy and was a little more clear minded. Other than that I cant report any changes. It might have just been a placebo like effect.

 

[JBrandon]

The real question to consider is that when the brain releases oxytocin, say in response to another drug like MDMA or the presence of your significant other, it probably does not flood all of the CNS and periphery with oxytocin to stimulate all possible oxytocin receptors in the body, rather it releases it to a specific set of neurons to get the desired effect (ie, bonding).

But when you do something like intranasal oxytocin where you take a huge dose just to get a "decent" amount into the brain, and a bunch of that initial dose just ends up falling down your nasal pathways into your periphery, you end up activating all of the oxytocin receptors in the body and brain and you get all of the effects... both those desirable and undesirable.

I was just going to post this!

It's not always about what neurotransmitters are released, even though everyone loves to simplify everything into a primarily "dopamine releaser" or "serotonin releaser". It's equally important to the effects of a drug to know which parts of the CNS are being activated.

I'm definitely going to search out your old posts about your oxytocin experiences though - it sounds interesting!

 

[PsychedelicPeptide]

Oxytocin can pass through the nasal cavity if it is applied at a high enough concentration. It is not very efficient at all, which is why people need to use a lot with good technique to get an effect but you can force it through still.

Godzilla you should try to do something involving faces and facial recognition on the oxytocin. This may work the best to notice an effect. Also you can gauge effectiveness by how often you pee after use. If you pee less than a few hours after using it, you probably didn't use enough. ;P