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Oxytocin & MDMA -- The real deal.

Maybe the oxytocin doesn't have to cross the BBB to cause a blowup. Have you ever smelled a particular scent and been transported back to a memory from your childhood? Maybe just getting a nose-full of the trust/love hormone while rolling is enough to cause a massive brain response. Maybe the brain thinks you're nose deep in a lover ;)? That'd probably cause a release of norepinephrine, dopamine, and endogenous oxytocin.
 
Black said:
yup.

with all the posts about oxycodone i think this thread will get better responses over there...
Click to expand...

when he was saying oxy i thought it might be oxycodone but realized oxytocin had to be a different chemical given what he described... It never makes your pupils bigger...
 
Dumbats. Mind you he never mentions "hormone", calling it a drug, and does refer to it as "oxy" which is a little odd.
 
Having just written a book about oxytocin, I have to chime in here, even though I'm quite late to the party.

First, inhaling oxytocin absolutely crosses the blood/brain barrier to affect the centers dealing with social interaction. cf the many experiments by PaulZak, pauljzak.com. The bbb is kind of an outdated concept. A lot of researchers are testing oxytocin for social anxiety, autism, schizophrenia and depression, and there are documented effects from inhaling, including increased empathy, trust and generosity.

Second, MDMA has been show to cause elevated levels of oxytocin. It probably affects the brain in the same way that being with someone you trust does, by provoking an oxytocin release. Therefore, the drug makes you more open to trust and connecting with others. I think someone else has posted a study or two; just go to scholar.google and search for Methylenedioxymethamphetamine +oxytocin.

My understanding is that a solution of pure oxytocin in saline is only stable for a short time; I'm wondering if it would last for an entire evening.

The effects of oxytocin by itself may be subtle and seem to depend a lot on your environment. If you're around other people who are open to connecting with you, you're more likely to feel the oceanic effect.

Finally, don't feel bad if you get oxytocin confused with the pain-killer. My mom still can't understand why I'd want to write a book about oxycontin.
 
Welcome to Bluelight :)

Can you elaborate a little on why you consider the blood-brain barrier to be an outdated concept? Also, I was under the impression that oxytocin was eliminated from the blood stream in a manner of minutes -- does it continue to have an effect beyond its elimination (due to sympathetic endogenous oxytocin release, perhaps), or is it a short-lived thing?

I have no doubt the MDMA causes release of oxytocin, but I imagine it does so on a more consistent basis during your experience since the 5-HT1a receptors are being consistently stimulated. Does this extended release differ in anything but duration from intranasal administration?

One final question: I don't have any sources to back this up, but I've heard that oxytocin receptors behave differently from other receptors -- specifically, they supposedly don't downregulate in the same way. Is there a difference between them and, say, serotonin receptors in terms of downregulation under exposure to oxytocin, or is it the same?

Thanks!
 
Can't a thread just die of natural causes?

So this thread is distracting the fuck out me right now. Bah Humbug, was trying to work. I don't want to invest the time to re-research what I just lost in the internet's skirt somewhere, not knowing how relevant it would be when I came across this old ass thread a few minutes later. Ya'll probably already know but I thought it was interesting nobody's mentioned it thus far:
Safrole is supposedly released in the breast milk of animals that never ingested Safrole (not sure what animal), the same as oxytocin. Possibly during birth too?
It's a real interesting experience. The newborn is high on DMT, the mom's all buggered on oxytocin and safrole and whatever other non-naturally occurring shit they give her at the hospital. And how does this coincide w/ the studys saying sass is lethal to newborns?

On a side note: This crazy dude, Strike was doing some Molly and Coke the other night and noted some unusual effects, was hoping someone could help explain what fucking chemical reaction was going on. Strike ingested way less than a tenth (low tolerance) of some uncut Mol around 4:30pm. He took a shower, the molly rushed and he orientated himself to it. Strike started doing lines of west coast coke around 6. All cool, social happy whatnot. By 9 Strike is also imbibing a fair amount of east coast coke. He does not remember when but progressively Strike felt paralyzed like he could not say or think anything, stroke, tabula rasa stylee. Normally he is very articulate, and wordy while high on stimulants but on this occasion he could not comfort himself nor participate in the beaming conversation. Every time Strike did a line of coke he would not be numb but all of a sudden aware and able to speak, but then it'd wear off. Around 5am Strike said 'Fuck it!' and proceeded to take a couple bars of xanax to reassemble himself. Thank you in advance for your input.

Melvin Junko
 
...

Oh yeah, and if you don't mind feeding my laziness, what causes the oxytocin to break down so fast? The same as L, light heat and air? Thanks
 
thankyouuniverse.. The affects you describe your friend of getting is what me and my friends call being spacked out.. brain dead in a way.. was he smoking cannabis by any chance? As mixing cannabis with tail end mdma / upper is a sure fire way to spack me out.

and once again for the nubs:

Oxytocin (which this thread is about) is NOT OxyContin
 
Neither is it about combining cocaine and MDMA.

To return us back to the original subject...

Naturaloxytocin, thanks for chiming in. I have yet to hear about inhaling oxytocin. Through an aerosol-type device? Certainly sounds promising. The question is how does one go about making one? ... onto the other points.

The reason for oxytocin instability is primarily that virtually all peptides & proteins are susceptible to degradation by microscopic bacteria that floats around, is on surfaces, etc. Generally it takes a few days for most peptides & proteins to start to get chopped up in a relatively clean water-based solution that is contaminated by non-sterile air and kept at room temperature.

You can prevent this to certain extents though. For example, IGF-1 dissolved in a few percent acetic acid (which prevents bacterial growth in the solution from its acidity) in water is stable in a fridge for months. Unfortunately, insuffulating an acetic acid solution of oxytocin would burn like the dickens, so this is not an option.

In terms of its stability in a non-sterile saline solution, I'm sure it's more than a few hours. Probably along the lines of a few days, but if it is kept frozen, it should be ok for a few months. Probably not more though. This is based on qualitative analysis though. Published work on oxytocin formulation says it is 100% stable in sterile saline solutions (I believe unfrozen) for months at a time.

I believe part of this is because the disulfide bond it contains. Peptide/protein stability is sometimes a function of the rigidity of the molecule itself. That is, things with lots of flexibility tend to be more susceptible to degradations like deamidation, transamination and hydrolysis of amide bonds in the backbone. Hence, an "end-to-end" tied up short peptide like oxytocin should be pretty stable under favorable conditions. A little lesser known biochemistry for you bluelighters out there. ;P
 
thats some interesting info PP


however, we're getting away from the main topic wich is, does Oxytocin really improve the mdma experience and how

i'm very curious about it
 
Haha, hey I started this thing. If anyone is allowed to derail it should be me. =)

I think the potential for synergy was addressed somewhat in the original post. You know it's funny looking back at posts made only less than a year ago, and realizing you forgot a lot about it hehe.

Sometimes individuals may forget about something and then later reflect back on their actions, and realize they kind of forgot how good something may really have been. Or that at that time their ability to conduct experimentation was only on somewhat lesser scales, and that at later times they realize they could retry it in a much more controlled setting. And with more materials. =O
 
We're not talking about oxycontin here!!!

Ok it wasn't bothering me before, but someone please put an end to it! Just close the thread ahhhhhhhh!!! (or open a secret oxytocin - MDMA discussion thread open only to members who send an application for access to it, declaring that they know either the amino acid sequence of oxytocin or can explain any difference between the oxytocin receptor and an opioid receptor).
 
^^ Move it to ADD.. I'm sure there will be alot less to none of these oxycontin posts..

And Zzyzx i thought "how would oxytocin improve the mdma experience" was obvious? :p The chemical responsible for trust, love and empathy(?) (Which are the main parts of the MDMA experience that i would relate to the Magic) being sprayed up your nose to then be release in high amounts by MDMA.. wether direct or not.. should feel lovely :)
 
Well then you would expect for oxytocin by itself to also be very MDMA-ish. However this is not really the case. It seems to be a little more noticeable/powerful when the two are used in conjunction. Hence the other effects of MDMA could be doing something to amplify the oxytocin. Or the combined release of endogenous oxytocin by MDMA with exogenous oxytocin by the user just catapults you into some "super oxytocin state" that just is not achievable with either MDMA alone or nasal administration of oxytocin.
 
No, oxy, mdma

I know everyone's done the viagra MDMA thing, and too many off you the oxytocin mdma viagra deal. Has anyone heard of an IM or IV shot of NO (nitric oxide) and orally/intranasally ingesting the OXYTOCIN and MDMA as normal. Was curious as to any possible harmful side effects of that grab bag?

and thank you kindly: injectable NO patent
7. A method of administering NO to a localized arterial site of a patient comprising preparing an aqueous pharmaceutical composition comprising NO by passing argon through a sterile injectable 0.9% sodium chloride solution in the absence of oxygen until any residual oxygen is removed; subsequently passing NO through the argon treated sodium chloride solution until the solution becomes saturated with NO; and intrarterially administering a bolus of the resultant NO saturated saline solution to a patient at a predetermined intrararterial site.
Click to expand...
 
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