Oxytocin agonists

[PsychedelicPeptide]

My experience with PT-141 is that it is garbage. I found MT-II to provide much more of the sexual side effects that melanocortin agonists can have. But either way they both should probably be avoided as they are too non-specific. MT-II started to effect my vision in a very bad way after a few months of once weekly use. Fortunately the effect only lasted around 6-12 months after stopping use... I suspect it to have been caused by activation of melanocortin receptors in the retina, in unnatural or excessive manners. I discussed it in greater detail over on the main melanotan forum website, I forget the name right now.

Oxytocin is administered intranasally because this bypasses the BBB, instead relying on passive diffusion through a few layers of membrane in the nasal cavity to get directly into the cerebrospinal fluid. That's not to say it is the most effective way to get it there, but it works to a certain extent.

There are a lot of questions still surrounding oxytocin and its use as a pharmacological agent... my belief is that the potential for its receptor as a drug target is yet to be fully realized.

 

[Tsukasa]

Oops. I should have been more specific. Mu-opioid receptor agonists stimulate the release of vasopressin, right?

By the way, how did the sophora prostrata affect you psychologically? Did it make you feel depressed? Did it cause you to hallucinate?

I wrote an extensive experience report on erowid on sophora. Not sure if it's published yet, it usually takes a long time. I can't find it anywhere on my laptop. But yea their were all the typical effects of an opioid including sedation, respiratory depression. It did also have a psychadelic effect. No significant hallucinations just altered thoughts and perceptions similiar to low dose sublingual salvia.

 

[yaesutom]

/Has anyone ever tried Bremelanotide (PT-141)? http://www.researchpeptides.com/PT-1...duct-flyer.php

It's supposed to be able to dramatically increase libido and quality of erections. Caution should be taken, though, as it can cause hypertensive crisis.

I've tried it and it just seemed to work like viagra or tadalafil, it didn't do anything to increase libido in the(my) brain.

 

[vinylmesh]

I have a sneaking suspicion one of these would be quite interesting and am having some trouble finding articles on my university's databases. However, I know some articles are out there. Any ideas or help would be great.

Oxytocin won't cross the Blood-brain-barrier. If intranasal use of such compounds did work then there'd be no need for drugs, and we'd all just use dopamine/serotonin/b-endorphin ect. nasal sprays

I skimmed through an article about oxytocin agonists once (which was available on the computers at uni), however for me to post it would be illegal, and i'm not sure if it's the type of behaviour bluelight would like to encourage.

The most potent/selective (not sure which one) compound was labelled "39" and is now my avatar. I have no idea whether or not this would cross the Blood-brain-barrier, and as far as i know no humans have ever taken it before.

If we want to create a drug or mixture of drugs simmilar to MDMA,but safer. I have a feeling these compounds will play a central role.

 

[Doctor Abalaba]

I heard PT-141 was really a bomb too, despite it's hype. To bad for Palatin.

Its interesting you guys bring a commonality between MDMA and Opiates. At lower doses, the "empathy" is considerably similar in some people. For example, that same similarity is absent in morphine, diacetylmorphine, and methadone, while those such as oxy- hydrocodone/morphone, and even codiene do elcilit that "lovely-" (for lack of a better work) feeling.

 

[MurphyClox]

Oxytocin won't cross the Blood-brain-barrier. If intranasal use of such compounds did work then there'd be no need for drugs, and we'd all just use dopamine/serotonin/b-endorphin ect. nasal sprays

Nope, I fear that crossing the BBB is just one part of the story. Even if one would find a way to make certain neurotransmitters cross the BBB, they would be quite unselective (bah! ) and some of them would get metabolized to a major degree before they reach their targets. Check 'LADME' if you should not know it...

- Murphy

 

[Blador]

are you sure oxytocin won't cross the bbb? How to explain the studies on it's psychological effects then? And why would people even bother making such studies?

Well, maybe it just acts on the areas of the hypothalamus where the BBB is less restrictive. Or maybe there's some indirect action through the release of other hormones outside of the cns...

Yeah, and dopamine probably wouldn't work as a great euphoriant when injected into the brain, just as levodopa and dopamine agonists don't

 

[Doctor Abalaba]

Although there is some controversy amid psychologists in my department on whether or not oxytocin, itself, crosses the BBB, the the neuro/biologists don't seems to argue. I've been siding with the latter. I, as a G.E.Psyc grad student, think much of the Psyc field is questionable. Human subjects are [statistically] unreliable at best. Reference the behavioral study, I'm sure there are at least three or four majors questionable issues.

 

[Newfie4Life]

Not sure of any specific agonists but lithium carbonate significantly raises oxytocin levels and oxytocin release in the brain.

 

[Kolmogorov]

IM oxytocin

I've performed a blind experiment of IM oxytocin 1 IU versus IM saline. On a subjective measure of sociability, I felt a 9 on a scale of 0-10 with oxytocin, and 7 with saline. Will try it again to see if that effect holds. I've seen several papers on Pubmed linking intranasal oxytocin to increased sociability and increased trust, and oxytocin agonists may be a potential treatment for social deficiencies in autism and schizophrenia.