Opioids oxymorphone + bupe patch??

[cyniclove]

My boyfriend got prescribed a buprenorphine patch AND a full agonist, oxymorphone.
For chronic pain and breakthrough pain, respectively.

Doesn't bupe block other opiates?


& how effective is buprenorphine for chronic pain? It's 10mcg/hour. Lower the dose=lower the binding=allowing a full agonist to be recieved so the duo completely saturates the opiate receptors?

 

[bayhead415]

This is very confusing.... Let me look up an article to link and it may point out similar or separate action.

Edit: http://www.painphysicianjournal.com/2008/april/2008;11;S133-S153.pdf

Also I have used the 5 mcg/h patch and it is kind of effective at first, but I was smomking cannabis as well. I also was alergic to the adhesive and would get rashes afterwords... Also bupe is supposed to increase your tollerance to opiates substantially...

I would stick with the oxymorphone....

Edit 2: The article does not have much on bupe... I will look up more info.

Edit 3: I think they both antagonize the same area.... I do not know what the competition for the receptor area will affect it, but just letting you know I think they both activate a response from the MU opiate receptor area.

Edit 4: Bupe confuses me very much... The pharmacology seems way above my head.

 

[Captain.Heroin]

It's very possible to use oxymorphone on top of a buprenorphine patch. If you were to take a large dose of buprenoprhine, it would block the effects of oxymorphone. However, a buprenorphine patch slowly releases buprenorphine over time. As well, the bioavailability of transdermal buprenorphine is fairly low.

 

[bayhead415]

With my experience using a 5 mcg/h patch for 2-3 days after not using it for a month or two and replacing it with levorphanol only to cease that and end up W/D worse than I ever have even off a 2 month opana habit cold turkey caused issues with using roxicodone. It took me 24 hours about to be able to use roxicodone with a regular effect after removing the patch. Do not underestimate the strength of the patch as it is strong, but I feel loses its strength as it constantly releases the same dose without allowing the body time to become less tolerant to it leading to it becoming noneffective over time. Although oxycodone acts differently than oxymorphone. To say the least the roxi had effect with the bupe patch, but definitely a lot less effect than it should have.

 

[Jktm]

The notation 'x'µg/hr is a bit misleading. This is just a mean figure for dosing, they origianlly release more than printed on the prescription, but then become less potent as more time goes on (hence why you peak at day 3 and are below half this by scheduled patch change). This made it hell trying to get by on these patches as I'd get to where I almost got some decent pain relief at peak levels, but then every day was experiencing steadily higher pain levels after that. They were also a pain in the ass because of the way they irritated the piss out of your skin. By the time I would remove the patches, they would actually be hurting at the application site, my skin would feel like leather, and it would be completely red and often broken out. I hated those things SO much. And ya, it has a transdermal bioavailability of 15%, so you don't get much of it at all. Of the (avg.)480µg that would get pumped into me a day I was really only getting about 72µg into my bloodstream.